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This work establishes a mechanism by which histone deacetylases SRT1 and SRT2 interact with ENAP1 to mediate transcriptional repression by regulating the levels of histone H3 lysine 9 acetylation in the ethylene signaling
Our findings revealed a novel regulatory mechanism of innate immunity by SIRT1.
SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.
data suggest that miR-221 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity, at least in part, through suppressing SIRT1.
CTXA alleviates LPS-induced liver injury by reducing inflammatory responses and the potential mechanism is associated with SIRT1 signaling activation and finally could be used to treat liver diseases
results demonstrate that Sirt1 overexpression in MSCs increased the osteoblastic bone formation and partially restores the defects in skeletal growth and osteogenesis in Bmi-1(-/-) mice by FOXO3a deacetylation and oxidative stress inhibition
we identified Sirt1 as a direct target gene of miR-361-5p and re-introduction of Sirt1 largely abolished the metabolic action of miR-361-5p
Oxidative stress in the lung after injury induces redox modification of SIRT1 and contributes to priming of the lung for a second-hit response.
These data demonstrate that SIRT1 directly inhibits osteoclastogenesis by inhibiting ROS generation and TRPV1 channel activation under mediation of TNF-alpha.
SIRT1 promotes FGF21 signalling in oxytocin neurons and stimulates Oxt transcription through NRF2.
A common pathway connecting n-MYC, NAMPT and SIRT1 may be active in basal cell carcinomas and in their cells of origin, contributing to their development.
These data implicate SIRT1 as playing a vital role in reactive oxygen species-directed lineage commitment of mesenchymal stem cells.
These findings show that miR-204 is obligatory for vascular endoplasmic reticulum stress and endoplasmic reticulum stress-induced vascular endothelial dysfunction, and that miR-204 promotes vascular endoplasmic reticulum stress via downregulation of Sirt1.
Study utilizing calcium oxalate (CaOx) crystal-induced renal injury mouse model showed reduced expression of Sirt1 in the kidney of the mice in the CaOx crystal group, revealing the potential role of Sirt1 in the nephrolithiasis.
this study provides the first evidence that SIRT1 mediates the anxiolytic effect of apelin-13 in chronic normobaric hypoxia -treated mice through the inhibition of NF-kappaB pathway
these findings indicate that silibinin-induced autophagy is mediated by up-regulation of PPARalpha-sirt1-AMPK, contributing to repression of type I collagen-enhanced migration in murine 3T3-L1 preadipocytes through down-regulation of phosphorylated NF-kappaB p65.
SNHG12 targets miR-199a to upregulate SIRT1 expression, which attenuates cerebral ischemia/reperfusion injury through AMPK pathway activation.
SIRT1 overexpression supresses renal lipid accumulation in offspring born to high-fat diet dams. SIRT1 overexpression suppresses renal oxidative Stress and inflammation markers in offspring born to high-fat diet dams. SIRT1 overexpression attenuates renal inflammation but not albuminuria in offspring born to high-fat diet dams.
Low SIRT1 expression is associated with reduced longevity and physical endurance.
Downregulation of miR-199a might protect lung tissue against sepsis-induced acute respiratory distress syndrome by upregulation of SIRT1 through the suppression of excessive inflammatory responses and the inhibition of cellular apoptosis in lung tissue.
Interplay between Nampt biosynthesis and SIRT1 regulation involves a novel regulatory pathway that responds to chronic cocaine stimuli.
Long non-coding RNA H19 (H19) regulated the proliferation and migration of cardiac progenitor cells (CPCs) through mediating the expression of sirtuin 1 (Sirt1) which is a target of miR-200a-3p under hypoxia.
Sirt1 negatively regulates Fc epsilon RI-stimulated mast cell activation and anaphylaxis through two mutually regulated pathways involving AMP-activated protein kinase (AMPK) and protein tyrosine phosphatase 1B.AMPKalpha2 reciprocally activates Sirt1 in mast cells.
Here, the authors demonstrate that SIRT1 promotes the fidelity of human papillomavirus type 16 E1-E2 replication and that the absence of SIRT1 results in reduced recruitment of the DNA repair protein Werner helicase (WRN) to E1-E2-replicating DNA.
high level of HIF-1alpha and SIRT1 was related to the characteristics of CSCs in ovarian cancer. Our data suggested that HIF-1alpha and SIRT1 could be predictors for chemoresistance and prognosis of ovarian cancer
improvement in nutritional status is positively associated with sirtuin 1 gene expression
genetic variant rs10823108 in SIRT1 and variant rs17446614 in FoxO1 may contribute to the risk of DN in T2DM patients.
The computational and experimental approaches suggest SIRT1 positively regulates circadian clock function through actions on PER2 and PGC1a.
results indicate that reduced peripheral blood SIRT1 mRNA could be a trait feature of depression.
this review underlies the specific mechanisms involved in breast, lung and prostate threatening cancers by microRNAs/SIRT1 pathways. [Review]
SIRT1/LKB1/AMPK pathway was involved in genistein accelerating autophagic flux and mitigating senescence in HUVECs. The present study illustrated that genistein was a promising therapeutic agent to delay aging process and extend longevity.
Data indicate an altered urinary expression of sirtuin 1 (SIRT1) and a strong association with disease activity in lupus nephritis (LN) patients, being a valuable marker of renal injury.
SIRT1 gene expression is altered in adipose tissue from overweight or obese subjects compared to normal weight subjects.
SIRT1/GLUT1 axis promotes bladder cancer progression via regulation of glucose uptake
SIRT1 participates in cAMP-enhanced nucleotide excision repair and deacetylates XPA at the Lys-63, Lys-67, and Lys-215 residues.
SIRT1 and SIRT2 expression and AMPK levels decrease in children with obesity and insulin resistance (IR); targeting SIRT1 can be valuable in preventing obesity-associated IR in childhood and adolescence
SIRT1 and MMP-9 expression was inversely correlated in chronic rhinosinusitis tissue, supporting SIRT1 as a possible therapeutic target for nasal polyp formation.
Increased SIRT1 expression is associated with progression of primary open-angle glaucoma.
These findings suggest that reduced SIRT1-mediated deacetylation of HIF-1alpha contributes to the elevated levels of aromatase in breast tissues of obese women.
findings identify KDM2B as an H3K79 demethylase and link its function to transcriptional repression via SIRT1-mediated chromatin silencing.
Study did not find a significant association between the 6 common single nucleotide polymorphisms of the SIRT1 gene and kidney stone formation in the Eastern Chinese population.
The results of the current study indicate that dioscin may protect against coronary heart disease by regulating oxidative stress and inflammation via Sirt1/Nrf2 and p38 MAPK pathways.
Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.
SIRT1, p53 and NF-kappaB are involved in the control of both the proliferation and the apoptosis of ovarian cells.
the expression of SIRT1 is associated with the Mt number in oocytes
Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma to that of ATGL in adipocytes.
CDK5-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.
SIRT1 and LKB1/AMPK are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.
Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1.
The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein
Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.
Sirt1 regulates the expression of FABP3 gene in adipocytes, and PPAR gamma apparently plays an important role in this process.
the novel 12-bp indel of SIRT1 gene, the 7-bp indel of SIRT2 gene and the 26-bp indel of SIRT3 gene were firstly reported, respectively. The association analysis indicated that the indels within SIRT1 and SIRT2 genes were significantly associated with body measurement traits such as body weight, chest circumference, height at hip cross, hip width, body height, etc.
This is the first study demonstrating a role for AMPK-SIRT1-FOXO1 signalling pathway in regulating apoptosis in bovine intramuscular adipocytes.
The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.
Downregulation of SIRT1 and FoxO1 were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.
Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.
5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits
The expression profile of sirtuin 1 and sirtuin 3 in the liver, muscle, and adipose tissue of calves and bulls is reported.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
, NAD-dependent deacetylase sirtuin-1
, NAD-dependent protein deacetylase sirtuin-1
, SIR2-like protein 1
, regulatory protein SIR2 homolog 1
, sir2-like 1
, sirtuin 1 ((silent mating type information regulation 2, homolog) 1
, sirtuin type 1
, sirtuin (silent mating type information regulation 2 homolog) 1
, NAD-dependent deacetylase sirtuin 1