anti-RAF1 (RAF1) Antikörper

Bezeichnung:: anti-V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 Antikörper (RAF1)

Auf www.antikoerper-online.de finden Sie aktuell 870 V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) Antikörper von 33 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen RAF1 Proteine (18) und RAF1 Kits (17) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 948 RAF1 Produkte verfügbar.

Synonyme:: 6430402F14Rik, AA990557, BB129353, c-raf, cRaf, Craf1, D830050J10Rik, NS5, raf, Raf-1, RAF1, v-Raf

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	RAF1	5894	P04049
	RAF1	24703	P11345
	RAF1	110157	Q99N57
Alle Spezies anzeigen Weitere Synonyme anzeigen

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anti-Human RAF1 Antikörper:

anti-Rat (Rattus) RAF1 Antikörper:

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Verknüpfte Pathways mit anti-RAF1 Antikörper

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Am meisten referenzierte anti-RAF1 Antikörper

Human RAF1 Primary Antibody für IHC - ABIN966940 : Gabriel, Bravery, Dougherty, Kayley, Malster, Scales: Vascular access: indications and implications for patient care. in Nursing standard (Royal College of Nursing (Great Britain) : 1987) 2005 (PubMed)
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Human Polyclonal RAF1 Primary Antibody für DB, ELISA - ABIN4369727 : Gohlke, Kuhn, Case: Change in protein flexibility upon complex formation: analysis of Ras-Raf using molecular dynamics and a molecular framework approach. in Proteins 2004 (PubMed)
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Virus Polyclonal RAF1 Primary Antibody für ICC, IF - ABIN4340713 : Retallack, Di Lullo, Arias, Knopp, Laurie, Sandoval-Espinosa, Mancia Leon, Krencik, Ullian, Spatazza, Pollen, Mandel-Brehm, Nowakowski, Kriegstein, DeRisi: Zika virus cell tropism in the developing human brain and inhibition by azithromycin. in Proceedings of the National Academy of Sciences of the United States of America 2016 (PubMed)
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Human Monoclonal RAF1 Primary Antibody für FACS, IHC - ABIN969559 : Hofmann, Heinrich, Radziwill, Radziwil, Moelling: A short hairpin DNA analogous to miR-125b inhibits C-Raf expression, proliferation, and survival of breast cancer cells. in Molecular cancer research : MCR 2009 (PubMed)
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Human Monoclonal RAF1 Primary Antibody für FACS, IHC - ABIN969560 : Takezawa, Okamoto, Yonesaka, Hatashita, Yamada, Fukuoka, Nakagawa: Sorafenib inhibits non-small cell lung cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells. in Cancer research 2009 (PubMed)
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Human Monoclonal RAF1 Primary Antibody für WB - ABIN260776 : Chiloeches, Mason, Marais: S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3. in Molecular and cellular biology 2001 (PubMed)
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Human Polyclonal RAF1 Primary Antibody für DB - ABIN389828 : Duan, Cobb: Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
Human Polyclonal RAF1 Primary Antibody für IF (p), IHC (p) - ABIN712706 : Wu, Dong, Shi, Yu, Fu, Zhang, Cai, Zhao, Peng, Wu, Wu: Regulation of integrin ?V subunit expression by sulfatide in hepatocellular carcinoma cells. in Journal of lipid research 2013 (PubMed)
Human Polyclonal RAF1 Primary Antibody für IHC, WB - ABIN361884 : Dougherty, Müller, Ritt, Zhou, Zhou, Copeland, Conrads, Veenstra, Lu, Morrison: Regulation of Raf-1 by direct feedback phosphorylation. in Molecular cell 2005 (PubMed)
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Human Polyclonal RAF1 Primary Antibody für IHC, WB - ABIN362494 : Fabian, Daar, Morrison: Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase. in Molecular and cellular biology 1993 (PubMed)
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Weitere Antikörper gegen RAF1 Interaktionspartner

Human V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) Interaktionspartner

CRAF is a bona fide alternative oncogene (zeige RAB1A Antikörper) for BRAF (zeige BRAF Antikörper)/NRAS (zeige NRAS Antikörper)/GNAQ (zeige GNAQ Antikörper)/GNA11 (zeige GNA11 Antikörper) wild type melanomas
Authors evaluated the expression of known targets of miR (zeige MLXIP Antikörper)-125a and found that sirtuin-7 (zeige SIRT7 Antikörper), matrix metalloproteinase-11 (zeige MMP11 Antikörper), and c-Raf were up-regulated in tumor tissue by 2.2-, 3-, and 1.7-fold, respectively. Overall, these data support a tumor suppressor role for miR (zeige MLXIP Antikörper)-125a.
Overexpression of ciRS-7 in HCT116 and HT29 cells led to the blocking of miR-7 (zeige LILRB1 Antikörper) and resulted in a more aggressive oncogenic phenotype, and ciRS-7 overexpression permitted the inhibition of miR-7 (zeige LILRB1 Antikörper) and subsequent activation of EGFR (zeige EGFR Antikörper) and RAF1 oncogenes
miR (zeige MLXIP Antikörper)-497 could serve as a tumor suppressor and a potential early diagnostic marker of gastric cancer by targeting Raf-1 proto-oncogene (zeige RAB1A Antikörper).
RAF1 may have a role in survival in hepatocellular carcinoma, and indicate whether sorafenib should be used as a postoperative adjuvant
Mutational activation of Kit-, Ras/Raf/Erk (zeige EPHB2 Antikörper)- and Akt (zeige AKT1 Antikörper)- pathways indicate the biological importance of these pathways and their components as potential targets for therapy.
Results indicate that des (zeige DES Antikörper)-gamma-carboxy prothrombin (zeige F2 Antikörper) (DCP (zeige ACE Antikörper)) antagonizes the inhibitory effects of Sorafenib on hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) through activation of the Raf/MEK (zeige MAP2K1 Antikörper)/ERK (zeige EPHB2 Antikörper) and PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper)/mTOR (zeige FRAP1 Antikörper) signaling pathways.
DiRas3 (zeige DIRAS3 Antikörper) binds to KSR1 (zeige KSR1 Antikörper) independently of its interaction with activated Ras and RAF.
RhoA (zeige RHOA Antikörper)/ROCK and Raf-1/CK2 (zeige CSNK2A1 Antikörper) pathway are responsible for TNF-alpha (zeige TNF Antikörper)-mediated endothelial cytotoxicity via regulation of the vimentin (zeige VIM Antikörper) cytoskeleton.
Although Raf-1 gene is not mutated, an abnormality of Raf-1 kinase feedback regulation enhances its antiapoptotic function, and Raf-1 can still be a pharmaceutical target to increase chemotherapy or radiotherapy sensitivity in these cancer cells.

Zebrafish V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) Interaktionspartner

cdk10 (zeige CDK10 Antikörper) has roles in vertebrate development and a critical function in neurogenesis by modulation of raf1a expression
Our results indicate that Rb-Raf-1 interaction plays an important role in spontaneous hair cell regeneration in zebrafish
Zebrafish embryos with morpholino knockdown of raf1 demonstrated the need for raf1 for the development of normal myocardial structure and function.
analysis of the roles of Raf- and PI3K-signalling pathways in melanoma

Cow (Bovine) V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) Interaktionspartner

data suggest that G alpha(i3), Shc (zeige SHC1 Antikörper), Grb2 (zeige GRB2 Antikörper), Ras, and Raf-1 link Src (zeige SRC Antikörper) to activation of MAPK (zeige MAPK1 Antikörper) and to the AT(2)-dependent increase in eNOS (zeige NOS3 Antikörper) expression in PAECs

Mouse (Murine) V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) Interaktionspartner

BRAF (zeige BRAF Antikörper) and ROKalpha (zeige ROCK2 Antikörper) form independent RAF1 complexes in embryonic fibroblasts (MEFs) treated with epidermal growth factor (EGF (zeige EGF Antikörper)).
Mechanistically, BRAF (zeige BRAF Antikörper) and RAF1 operate independently to balance MAPK (zeige MAPK1 Antikörper) signaling: BRAF (zeige BRAF Antikörper) promotes ERK (zeige EPHB2 Antikörper) activation, while RAF1 dims stress kinase activation.
Neuroprotective (arylthio)cyclopentenone prostaglandins directly bind to c-Raf protein and protect cells from down-regulation of the c-Raf protein itself, resulting in protection against oxidative stress.
A- and B-Raf (zeige SNRPE Antikörper) ablation in chondrocytes does not alter skeletal development, whereas ablation of C-Raf decreases hypertrophic chondrocyte apoptosis and impairs vascularization of the growth plate. However, ablation of C-Raf does not impair phosphate-induced ERK1/2 phosphorylation in vitro, but leads to rickets by decreasing VEGF (zeige VEGFA Antikörper) protein stability.
We confirmed that Raf1(L613V) knock-in confers a NS-like phenotype, including cardiac hypertrophy. Active RSK3 (zeige RPS6KA2 Antikörper) was increased in Raf1(L613V) mice. Constitutive RSK3 (zeige RPS6KA2 Antikörper) gene deletion prevented the Raf1(L613V)-dependent concentric growth in width of the cardiac myocyte and attenuated cardiac hypertrophy in female mice.
C-Raf involves in osteoblast survival in response to mechanical stress.
Dual inhibition of c-Raf and soluble epoxide hydrolase (zeige EPHX2 Antikörper) by t-CUPM prevents mutant KrasG12D-initiated murine pancreatic carcinoma growth.
Simultaneous inhibition of sEH (zeige EPHX2 Antikörper) and c-RAF prevents chronic pancreatitis and murine pancreatic intraepithelial neoplasia in LSL-KrasG(1)(2)D/Pdx-1 (zeige PDX1 Antikörper)-Cre mice.
under normal physiological conditions, PTEN suppresses AKT (zeige AKT1 Antikörper) activity to maintain activation of the RAF1/ERK (zeige EPHB2 Antikörper) signaling pathway, which in turn maintains normal function of the initial segment and therefore, normal sperm maturation.
these data indicate that B-RAF (zeige SNRPE Antikörper) is an important factor in oncogenic C-RAF-mediated tumorigenesis.

Xenopus laevis V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) Interaktionspartner

Both c-Raf and B-Raf (zeige BRAF Antikörper) are required for Ras-induced MEK1 (zeige MAP2K1 Antikörper) and p42 (zeige EPB42 Antikörper) MAP kinase (zeige MAPK1 Antikörper) activation.

RAF1 Antigen-Profil

Beschreibung des Gens

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

Alternative names and synonyms associated with RAF1

Raf-1 proto-oncogene, serine/threonine kinase (RAF1) Antikörper
Raf-1 proto-oncogene, serine/threonine kinase (Raf1) Antikörper
Raf-1 proto-oncogene, serine/threonine kinase a (raf1a) Antikörper
Raf-1 proto-oncogene, serine/threonine kinase (raf1) Antikörper
v-raf-leukemia viral oncogene 1 (Raf1) Antikörper
Raf-1 proto-oncogene, serine/threonine kinase S homeolog (raf1.S) Antikörper

6430402F14Rik Antikörper
AA990557 Antikörper
BB129353 Antikörper
c-raf Antikörper
cRaf Antikörper
Craf1 Antikörper
D830050J10Rik Antikörper
NS5 Antikörper
raf Antikörper
Raf-1 Antikörper
RAF1 Antikörper
v-Raf Antikörper

Bezeichner auf Proteinebene für RAF1

, , , , , , , , , , , , , , , , , , , , , Oncogene RAF1 RAF proto-oncogene serine/threonine-protein kinase proto-oncogene c-RAF raf proto-oncogene serine/threonine protein kinase C-RAF cRaf murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV) raf-1 v-raf-1 murine leukemia viral oncogene homolog 1 murine leukemia viral oncogene homolog serine/threonine protein kinase RAF1 MIL proto-oncogene serine/threonine-protein kinase RAF-1 c-mil protein murine leukemia viral (v-raf-1) oncogene homolog 1 RAF proto-oncogene serine/threonine-protein kinase-like Craf1 transforming murine sarcoma 3611 oncogene 1 sarcoma 3611 oncogene v-raf-1 leukemia viral oncogene 1 Proto-oncogene c-RAF Raf-1

GENE ID	SPEZIES
5894	Homo sapiens
24703	Rattus norvegicus
30716	Danio rerio
396245	Gallus gallus
460182	Pan troglodytes
484648	Canis lupus familiaris
521196	Bos taurus
549871	Xenopus (Silurana) tropicalis
694725	Macaca mulatta
100173732	Pongo abelii
100347407	Oryctolagus cuniculus
100415300	Callithrix jacchus
100482255	Ailuropoda melanoleuca
100582599	Nomascus leucogenys
110157	Mus musculus
397857	Xenopus laevis
107131151	Bos taurus
100720110	Cavia porcellus

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