anti-MKNK1 (MKNK1) Antikörper

Bezeichnung:: anti-MAP Kinase Interacting serine/threonine Kinase 1 Antikörper (MKNK1)

Auf www.antikoerper-online.de finden Sie aktuell 138 MAP Kinase Interacting serine/threonine Kinase 1 (MKNK1) Antikörper von 19 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MKNK1 Proteine (11) und MKNK1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 167 MKNK1 Produkte verfügbar.

Synonyme:: 2410048M24Rik, MAPK signal-integrating kinase 1, mknk1, mnk1, zgc:171912

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	MKNK1	8569	Q9BUB5
	MKNK1	17346	O08605
	MKNK1	500526	Q4G050
Alle Spezies anzeigen Weitere Synonyme anzeigen

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Am meisten referenzierte anti-MKNK1 Antikörper

Human Polyclonal MKNK1 Primary Antibody für WB - ABIN2801944 : Fukunaga, Hunter: MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. in The EMBO journal 1997 (PubMed)
Show all 4 Pubmed References

Weitere Antikörper gegen MKNK1 Interaktionspartner

Human MAP Kinase Interacting serine/threonine Kinase 1 (MKNK1) Interaktionspartner

High MNK1 expression in epithelial ovarian cancer tissues indicates poor clinical outcomes
these data show that NDRG1 (zeige NDRG1 Antikörper) is regulated by the oncogenic MAP kinase (zeige MAPK1 Antikörper)-interacting kinase pathway, a target for cancer therapy
MKNK1 polymorphism was associated with treatment response in metastatic colorectal cancer.
Elevated levels of p-Mnk1, p-eIF4E (zeige EIF4E Antikörper) and p-p70S6K (zeige RPS6KB1 Antikörper) proteins are associated with tumor recurrence and poor prognosis in astrocytomas. Overexpression of p-eIF4E (zeige EIF4E Antikörper) and co-expression of p-Mnk1, p-eIF4E (zeige EIF4E Antikörper) and p-p70S6K (zeige RPS6KB1 Antikörper) proteins could be used as novel independent poor prognostic biomarkers for patients with astrocytomas.
MNK-1 controls chemokine (zeige CCL1 Antikörper) secretion and proliferation in human airway smooth muscle cells.
MNK1 encodes a Ser/Thr protein kinase that interacts with extracellular signal-regulated kinase 1 (zeige MAPK3 Antikörper) and p38 mitogen-activated protein kinase (zeige MAPK14 Antikörper), a pathway that is involved in Blood Pressure regulation through norepinephrine and angiotensin II.
Data show that galeterone (gal (zeige GAL Antikörper)) and VNPT55 inhibit migration and invasion of prostate cancer cells, possibly by down-regulating protein expression via antagonizing the Mnk1/2-eIF4E (zeige EIF4E Antikörper) axis.
data suggest a physiological role for MNK1a-Ser (zeige SIGLEC1 Antikörper)(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E (zeige EIF4E Antikörper) phosphorylation in vitro and in vivo.
Data suggest MNK1/MNK2 (zeige MKNK2 Antikörper) stimulate mRNA translation but only of mRNA containing both 5-prime-terminal cap and hairpin duplex; this stimulation involves up-regulation of phosphorylation/mRNA un-winding activity of eIF4E (zeige EIF4E Antikörper) (via decreased binding to eIF4G (zeige EIF4G1 Antikörper)).
Simultaneous targeting of androgen receptor (zeige AR Antikörper) and MNK1 by novel retinamides inhibits growth of human prostate cancer cell lines.

Mouse (Murine) MAP Kinase Interacting serine/threonine Kinase 1 (MKNK1) Interaktionspartner

MNK1 participates in mediating high-fat diet-induced insulin (zeige INS Antikörper) resistance. Our findings reveal distinct roles for the MNKs in a novel area of disease biology
data suggest a physiological role for MNK1a-Ser (zeige SIGLEC1 Antikörper)(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E (zeige EIF4E Antikörper) phosphorylation in vitro and in vivo.
Mnk1 is a novel pancreatic acinar cell-specific stress response kinase that regulates digestive enzyme abundance and eIF4E (zeige EIF4E Antikörper) phosphorylation.
Long-term potentiation (LTP (zeige SCP2 Antikörper)) consolidation in the dentate gyrus of live rodents requires sustained (hours) BDNF (zeige BDNF Antikörper)-TrkB (zeige NTRK2 Antikörper) signaling and from TrkB (zeige NTRK2 Antikörper) to MAP-kinase (zeige MAPK1 Antikörper)-interacting kinase.
Data suggest that Mnk1 and Mnk2 (zeige MKNK2 Antikörper) regulate cell migration/wound healing, expression of vimentin (zeige VIM Antikörper), stability of vimentin (zeige VIM Antikörper) protein, and binding of eIF4E (eukaryotic translation initiation factor 4E (zeige EIF4E Antikörper)) and Cyfip1 (cytoplasmic FMR1 interacting protein 1 (zeige CYFIP1 Antikörper)).
Mnk1/2 has a minimal role in T cell development and activation but may regulate non-T cell lineages to control Th1 (zeige HAND1 Antikörper) and Th17 differentiation in vivo.
oncogenic role for Mnk1/2 in tumor development
Mnk1 phosphorylation by caspase (zeige CASP3 Antikörper)-activated Pak2/gamma-PAK (zeige PAK2 Antikörper) inhibits phosphorylation and interaction of eIF4G (zeige EIF4G1 Antikörper) with Mnk (zeige ATP7A Antikörper)
Mnk2 (zeige MKNK2 Antikörper) and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E (zeige EIF4EBP2 Antikörper) but not for cell growth or development
Mnk (zeige ATP7A Antikörper) activation by oxidative stress leading to enhanced eIF4E (zeige EIF4E Antikörper) phosphorylation may play a role in promoting stress-induced hyperproliferative diseases, such as smooth muscle cell proliferation and hypertrophy in cardiovascular disease.

MKNK1 Antigen-Profil

Beschreibung des Gens

This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene.

Alternative names and synonyms associated with MKNK1

MAP kinase interacting serine/threonine kinase 1 (MKNK1) Antikörper
MAP kinase interacting serine/threonine kinase 1 (mknk1) Antikörper
MAP kinase-interacting serine/threonine kinase 1 (Mknk1) Antikörper
MAP kinase interacting serine/threonine kinase 1 (Mknk1) Antikörper
MAP kinase interacting serine/threonine kinase 1 S homeolog (mknk1.S) Antikörper

2410048M24Rik Antikörper
MAPK signal-integrating kinase 1 Antikörper
mknk1 Antikörper
mnk1 Antikörper
zgc:171912 Antikörper

Bezeichner auf Proteinebene für MKNK1

MAP kinase signal-integrating kinase 1 , MAP kinase-interacting serine/threonine-protein kinase 1 , MAPK signal-integrating kinase 1 , MAP kinase interacting serine/threonine kinase 1 , mnk1 , MAP kinase-interacting kinase 1

GENE ID	SPEZIES
8569	Homo sapiens
469189	Pan troglodytes
525647	Bos taurus
555974	Danio rerio
771961	Gallus gallus
17346	Mus musculus
500526	Rattus norvegicus
100720835	Cavia porcellus
387327	Xenopus laevis

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Show all anti-MAP Kinase Interacting serine/threonine Kinase 1 (MKNK1) Antikörper with Pubmed References

Human MAP Kinase Interacting serine/threonine Kinase 1 (MKNK1) Interaktionspartner

Mouse (Murine) MAP Kinase Interacting serine/threonine Kinase 1 (MKNK1) Interaktionspartner

Beschreibung des Gens

Alternative names and synonyms associated with MKNK1

Bezeichner auf Proteinebene für MKNK1