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Human MAPK14 Protein expressed in Baculovirus infected Insect Cells - ABIN2002027
Tamura, Sudo, Senftleben, Dadak, Johnson, Karin: Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. in Cell 2000
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The results reveal a new connection between p38MAPK, MYC (zeige MYC Proteine) and NOTCH (zeige NOTCH1 Proteine) signaling, demonstrate two mechanisms of NOTCH3 (zeige NOTCH3 Proteine) regulation and provide evidence for NOTCH3 (zeige NOTCH3 Proteine) involvement in prostate luminal cell differentiation.
Overall, these results suggest that p53 (zeige TP53 Proteine) is involved in improving insulin (zeige INS Proteine) sensitivity of hepatic cells via inhibition of mitogen-activated protein kinases (MAPKs) and NF-kappaB (zeige NFKB1 Proteine) pathways.
Data show that the combination of targeting RAD51 (zeige RAD51 Proteine) and p38 (zeige CRK Proteine) inhibits cell proliferation both in vitro and in vivo, which was further enhanced by targeting of PARP1 (zeige PARP1 Proteine).
Fas-FasL is the preferred death pathway for both Th1 and Th17 and that inherently low Erk2 activity protected Th17 cells from TCR AICD.
provide the first report that p38 (zeige CRK Proteine)-p38IP (zeige SUPT20H Proteine) is required for the Snail (zeige SNAI1 Proteine)-induced E-cadherin (zeige CDH1 Proteine) down-regulation and cell invasion in HNSCC
GATA4 (zeige GATA4 Proteine) is a regulator of osteoblastic differentiation via the p38 (zeige CRK Proteine) signaling pathways.
CX3CL1 (zeige CX3CL1 Proteine)/CX3CR1 (zeige CX3CR1 Proteine) axis plays a key role in the development of ischemia-induced oligodendrocyte injury via p38MAPK signaling pathway.
Data suggest that in vitro-induction of CD8 (zeige CD8A Proteine)+ Tregs depended in part on transforming growth factor beta 1 (TGF-beta1 (zeige TGFB1 Proteine)) activation of p38 MAPK signaling, and that p38 MAPK could be a therapeutic target in ovarian cancer (OC) anti-tumor immunotherapy.
present study provides evidence that variations in GADD45B (zeige GADD45B Proteine) rs2024144T, MAPK14 rs3804451A and GADD45A (zeige GADD45A Proteine) rs581000C may predict platinum-based chemotherapy toxicity outcomes in patients with advanced non-small cell lung cancer
Gab1/SHP2 (zeige PTPN11 Proteine)/p38MAPK signaling pathway and Ang-2 (zeige ANGPT2 Proteine) have an essential role in regulating thrombin (zeige F2 Proteine)-induced monocyte adhesion and vascular leakage
results suggest that ET-1 (zeige EDN1 Proteine)-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase (zeige NOX1 Proteine)-PKCalpha (zeige PKCa Proteine)-p(38)MAPK (zeige MAPK1 Proteine) and NFkappaB-MT1MMP (zeige MMP14 Proteine) signaling pathways along with a marked decrease in TIMP-2 (zeige TIMP2 Proteine) expression in the cells
cross-talk between p(38)MAPK (zeige MAPK1 Proteine) and Gialpha play a pivotal role for full activation of cPLA2 (zeige PLA2G4A Proteine) during ET-1 (zeige EDN1 Proteine) stimulation of pulmonary artery smooth muscle cells.
MAPK14 signalling pathway is largely involved in heat-induced sperm damage.
p38 MAPK is an early redox sensor in the laminar shear stress with hydrogen peroxide being a signaling mediator.
Blockade of p38 enhances chondrocyte phenotype in monolayer culture and may promote more efficient cartilage tissue regeneration for cell-based therapies.
p38 phosphorylation and MMP13 (zeige MMP13 Proteine) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
These data suggest that the p38 and JNK (zeige MAPK8 Proteine) signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection.
findings support the hypothesis that ischemic factor stimulation of the blood-brain barrier Na-K-Cl cotransporter (zeige SLC12A1 Proteine) involves activation of p38 and JNK (zeige MAPK8 Proteine) MAPKs
These data suggest a differential requirement of JNK1 (zeige MAPK8 Proteine) and p38 MAPK in TNF (zeige TNF Proteine) regulation of E2F1 (zeige E2F1 Proteine). Targeted inactivation of JNK1 (zeige MAPK8 Proteine) at arterial injury sites may represent a potential therapeutic intervention for ameliorating TNF (zeige TNF Proteine)-mediated EC dysfunction.
p38 MAPK (MAPK14) is redox-regulated in reactive oxygen species-dependent endothelial barrier dysfunction.
These results illustrate a novel pro-tumourigenic crosstalk between the p38 MAPK pathway and JAK (zeige JAK3 Proteine) signalling in a Drosophila model of Myeloproliferative neoplasms.
ROS (zeige ROS1 Proteine)/JNK (zeige MAPK8 Proteine)/p38/Upd (zeige UROD Proteine) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Taken together, our findings indicate that the p38 MAP Kinase is an integral component of the core circadian clock of Drosophila in addition to playing a role in stress-input pathways.
Data show that the genetic interaction between p38b MAPK (zeige MAPK1 Proteine) and Rack1 (zeige GNB2L1 Proteine) controls muscle aggregate formation, locomotor function, and longevity.
The interaction of any of several Drosophila Delta class glutathione transferases and p38b mitogen-activated protein kinase (zeige MAPK1 Proteine) can affect the substrate specificity of either enzyme, which suggests induced conformational changes affecting catalysis.
found a correlation between the depth of integration of individual p38 kinases into the protein interaction network and their functional significance; propose a central role of p38b in the p38 signaling module with p38a and p38c playing more peripheral auxiliary roles
Loss of p38 MAPK causes early lethality and precipitates age-related motor dysfunction and stress sensitivity.
The p38 pathway-mediated stress response contribute to Drosophila host defense against microbial infection.
p38b MAPK (zeige MAPK1 Proteine) plays a crucial role in the balance between intestinal stem cell proliferation and proper differentiation in the adult Drosophila midgut.
the D-p38b gene is regulated by the DREF (zeige ZBED1 Proteine) pathway and DREF (zeige ZBED1 Proteine) is involved in the regulation of proliferation and differentiation of Drosophila ISCs (zeige NFS1 Proteine) and progenitors
MKK4 (zeige MAP2K4 Proteine) is the major MAP2K, which activates JNK (zeige MAPK8 Proteine) in acute liver injury. p38 (zeige CRK Proteine), the other downstream target of MKK4 (zeige MAP2K4 Proteine), does not contribute to liver injury from APAP or TNF (zeige TNF Proteine)/galactosamine.
Endogenous hydrogen sulfide (zeige SQRDL Proteine)-mediated MAPK (zeige MAPK1 Proteine) inhibition preserves endothelial function through TXNIP (zeige TXNIP Proteine) signaling.
Suppressing P38 (zeige CRK Proteine) promoted adipogenic trans-differentiation and intensified adipolytic metabolism in differentiated cells. However, inhibition of ERK1/2 had the opposite effects on adipogenesis and no effect on adipolysis. Blocking JNK (zeige MAPK8 Proteine) weakly blocked trans-differentiation but stimulated adipolysis and induced apoptosis.
Our key findings provide novel insights into the mechanism of action of heterotrimeric complex (PKCdelta (zeige PKCd Proteine)-TIRAP (zeige TIRAP Proteine)-p38 (zeige CRK Proteine)) in proinflammatory cytokine expression, which controls the development of the inflammatory trigger in stimulated macrophages.
CXCL13 (zeige CXCL13 Proteine) acts on CXCR5 (zeige CXCR5 Proteine) to increase p38 (zeige CRK Proteine) activation and further contributes to the pathogenesis of orofacial neuropathic pain
p38 (zeige CRK Proteine) role in the Helicobacter pylori podocyte infiltration
Our data suggest that rCC16 suppresses LPS (zeige TLR4 Proteine)-mediated inflammatory mediator TNF-alpha (zeige TNF Proteine), IL-6 (zeige IL6 Proteine), and IL-8 (zeige IL8 Proteine) production by inactivating NF-kappaB (zeige NFKB1 Proteine) and p38 MAPK but not AP-1 (zeige JUN Proteine) in RAW264.7 cells.
high fat diet (HFD) and zinc deficiency synergistically induce obesity-related cardiac hypertrophy (ORCH), by increasing oxidative stress-mediated activation of BCL10 (zeige BCL10 Proteine)/CARD9 (zeige CARD9 Proteine)/p38 MAPK signalling. Zinc supplement ameliorates ORCH through activation of metallothionein (zeige MT Proteine) to repress oxidative stress-activated BCL10 (zeige BCL10 Proteine) expression and p38 MAPK activation.
involvement of CacyBP/SIP (zeige CACYBP Proteine) in the regulation of p38 (zeige CRK Proteine) kinase activity, in addition to that of ERK1/2, might point to the function of CacyBP/SIP (zeige CACYBP Proteine) in pro-survival and pro-apoptotic pathways.
cytochrome c (zeige CYCS Proteine) microinjection induces p38 phosphorylation through caspase-3 (zeige CASP3 Proteine) activation, and caspase (zeige CASP3 Proteine) inhibition reduces p38 activation induced by osmostress, indicating that a positive feedback loop is engaged by hyperosmotic shock
p38 mitogen-activated protein kinase is crucial for bovine papillomavirus type-1 transformation of equine fibroblasts.
p38 Mitogen-activated protein kinase (MAPK (zeige MAPK1 Proteine)) is essential for drug-induced COX-2 (zeige PTGS2 Proteine) expression in leukocytes, suggesting that p38 MAPK is a potential target for anti-inflammatory therapy.
These findings support a function for p38 MAPK in equine neutrophil migration and suggest the potential for the ability of p38 MAPK inhibition to limit neutrophilic inflammation in the laminae during acute laminitis.
Cultured equine digital vein endothelial cells were exposed to lipopolysaccharide and phosphorylation of p38 MAPK was assessed by Western blotting using phospho-specific antibodies.
Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 (zeige IL10 Proteine) production through p38 MAPK activation.
JNK (zeige MAPK8 Proteine) plays an active role in fragmentation of pig oocytes and p38 MAPK is not involved in this process.[p38MAPK]
Retinal ischemia-reperfusion alters expression of mitogen-activated protein kinases, particularly ERK1/2, in the neuroretina and retinal arteries.
These findings suggest that the TQ-induced production of ROS (zeige ROS1 Proteine) causes dedifferentiation through the ERK (zeige MAPK1 Proteine) pathway and inflammation through the PI3K and p38 pathways in rabbit articular chondrocytes.
These results suggest that p38 MAPK signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 plays a role by way of stimulating NF-kappaB (zeige NFKB1 Proteine), p53 (zeige TP53 Proteine) and caspase-3 (zeige CASP3 Proteine) activation.
P38 and JNK (zeige MAPK8 Proteine) have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
Adult zebrafish cardiomyocytes express active p38alpha MAPK (zeige MAPK1 Proteine), which is switched off upon entry into mitosis.
Dkk3r regulates p38a phosphorylation to maintain Smad4 (zeige SMAD4 Proteine) stability, in turn enabling the Smad2 (zeige SMAD2 Proteine).Smad3a.Smad4 complex to form and activate the myf5 (zeige MYF5 Proteine) promoter.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Csaids binding protein
, MAP kinase 14
, MAP kinase 2
, MAP kinase Mxi2
, MAP kinase p38 alpha
, MAPK 14
, MAX-interacting protein 2
, cytokine suppressive anti-inflammatory drug binding protein
, cytokine-supressive anti-inflammatory drug binding protein
, mitogen-activated protein kinase 14
, mitogen-activated protein kinase 14A
, mitogen-activated protein kinase p38 alpha
, p38 MAP kinase
, p38 mitogen activated protein kinase
, p38alpha Exip
, reactive kinase
, stress-activated protein kinase 2A
, p38 mitogen-activated protein kinase
, stress-activated p38b MAP kinase
, cytokine suppressive anti-inflammatory drug binding protein 1
, mitogen activated protein kinase 14
, p38 MAP kinase alpha
, p38 MAPK
, p38 alpha
, tRNA synthetase cofactor p38
, MAPK p38
, Mitogen-activated protein kinase 2
, mitogen-activated Mitogen-activated protein kinase 2
, p38 mitogen-activated kinase
, CSAIDS-binding protein 1
, stress-activated protein kinase 2a
, MAP kinase 14A
, MAP kinase p38a
, MAPK 14A
, Mitogen-activated protein kinase p38a
, mitogen-activated protein kinase p38a