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Human MAPK10 Protein expressed in Wheat germ - ABIN1310260
Prause, Christensen, Billestrup, Mandrup-Poulsen: JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis. in PLoS ONE 2014
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
mitogen-activated protein kinase 10
, MAP kinase 10
, MAPK 10
, Stress activated protein kinase beta
, c-Jun N-terminal kinase 3
, stress-activated protein kinase JNK3
, JNK3 alpha protein kinase
, MAP kinase p49 3F12
, stress activated protein kinase beta
, stress-activated protein kinase 1b
, JNK3 beta1 protein kinase
, JNK3 beta2 protein kinase
, SAPK/Erk/kinase 2
, mitogen activated protein kinase 10