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DAPK deficiency leads to excess HIF-1a (zeige HIF1A Proteine) accumulation, enhanced IL-17 (zeige IL17A Proteine) expression and exacerbated experimental autoimmune encephalomyelitis.
Excitotoxicity can proceed without increased Ser (zeige SIGLEC1 Proteine)-1303 phosphorylation, and is unaffected by Dapk1 deficiency in vitro or following ischemia in vivo.
Authors find that the LTP (zeige SCP2 Proteine) specificity of CaMKII (zeige CAMK2G Proteine) synaptic accumulation is due to its LTD-specific suppression by calcineurin (CaN)-dependent DAPK1 activation, which in turn blocks CaMKII (zeige CAMK2G Proteine) binding to GluN2B (zeige GRIN2B Proteine).
DAPK1 specifically phosphorylates NDRG2 (zeige NDRG2 Proteine) Ser350 and this phosphorylation is an important caspase (zeige CASP3 Proteine)-dependent mechanism by which NDRG2 (zeige NDRG2 Proteine) mediates cell death in neuronal cells.
Inhibition of DAPK1 by deleting a catalytic domain or a death domain of DAPK1 rescues the Excitatory pyramidal neurons in the entorhinal cortical layer II region synaptic loss
in Alzheimer's disease (AD) brains, elevated DAPK1 levels showed co-relation with the increase of APP (zeige APP Proteine) phosphorylation. Combined together, these results suggest that DAPK1 promotes the phosphorylation and amyloidogenic processing of APP (zeige APP Proteine), and that may serve a potential therapeutic target for AD.
This study demonstrate that phosphorylation of Tau at Serine 262 by the kinase domain of DAPK1 mediates spine damage and the subsequent neuronal death in ischemic stroke.
DAPK1-p53 (zeige TP53 Proteine) interaction is a preferred target for therapeutic intervention of stroke.
Suggest that DAPK1 is a novel regulator of tau protein abundance, and that DAPK1 upregulation might contribute to tau-related pathologies in Alzheimer disease.
the DAPK1-p53 (zeige TP53 Proteine) interaction is a signaling point of convergence of necrotic and apoptotic pathways
DAPK1 methylation level is associated with gliomas clinical features and outcomes
LncRNA MIR22HG could act as a tumor suppressor and inhibited EC cells proliferation through regulating miR (zeige MLXIP Proteine)-141-3p/DAPK1 axis.
Our results showed that DAPK promoter methylation is tightly correlated with clinicopathological features of NSCLC and is associated with poor prognosis in patients.
High Promoter Methylation of DAPK1 gene is associated with Breast Cancer.
It is this DAPK1-NR2B (zeige GRIN2B Proteine) interaction that arbitrates the pathological processes like apoptosis, necrosis, and autophagy of neuronal cells observed in stroke injury, hence we aimed to inhibit this vital interaction to prevent neuronal damage.
DNA hypermethylation of DAPK1 gene promoter is a promising biomarker for OSCC prediction/prognostics
rs4878104 T allele could significantly regulate increased DAPK1 expression in European population
the DAPK-mTOR (zeige FRAP1 Proteine) pathway is critical for anti-HCV effects of peg (zeige PAEP Proteine)-IFN-alpha (zeige IFNA Proteine)
A significant correlation between changes in the levels of expression and methylation was detected for the three apoptosis-regulatory genes (APAF1 (zeige APAF1 Proteine), DAPK1, and BCL2 (zeige BCL2 Proteine)). The results suggest that methylation play an important role in the regulation of the apoptosis system genes in breast cancer.
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.
death-associated protein kinase 1
, death-associated protein kinase 1-like
, DAP kinase 1