anti-Ezrin (EZR) Antikörper

Human Ezrin (EZR) Interaktionspartner

1. ezrin facilitates AQP2 (zeige AQP2 Antikörper) endocytosis, thus linking the dynamic actin cytoskeleton network with AQP2 (zeige AQP2 Antikörper) trafficking.

2. FUT4/LeY was critical to the TAMs-mediated EMT; this process might be associated with the up-regulation of Ezrin phosphorylation by FUT4/LeY-mediated fucosylation

3. CPI-17 (zeige PPP1R14A Antikörper) drives Ras activity and tumorigenesis in melanomas in a two-fold way; inactivation of the tumor suppressor merlin (zeige NF2 Antikörper) and activation of the growth promoting ERM (zeige ETV5 Antikörper) family.

4. Data suggest that EGF (zeige EGF Antikörper) induces colorectal cancer cells to undergo epithelial-mesenchymal transition, enhances their ability to invade/migrate, and promotes phosphorylation of Ezrin at Tyr353. (EGF (zeige EGF Antikörper) = epidermal growth factor (zeige EGF Antikörper))

5. Binding of phosphatidylinositol 4,5-biphosphate to ezrin induces a conformational change permitting the insertion of the LOK (zeige STK10 Antikörper) C-terminal domain to wedge apart the membrane and F-actin-binding domains of ezrin. The N-terminal LOK (zeige STK10 Antikörper) kinase domain can then access a site 40 residues distal from the consensus sequence that collectively direct phosphorylation of the appropriate threonine residue.

6. The expression pattern and subcellular localization of ezrin and moesin (zeige MSN Antikörper) correlate with clinicopathological variables such as patients' age, tumor grade and hormonal status.

7. Ezrin represents a promising target for the development of strategies aimed at preventing the progression of cervical cancer.

8. Ezrin S66 phosphorylation enhances filopodia formation, contributing to the regulation of invasion and metastasis of esophageal squamous cell carcinoma cells

9. Ezrin protein expression is a promising biomarker in estimating the outcome of stage II colorectal cancer patients. When combined with microsatellite status its ability in predicting disease outcome is further improved

10. Ezrin is down-regulated during cholangiocarcinogenesis, and its loss results in a more aggressive phenotype.

Rabbit Ezrin (EZR) Interaktionspartner

1. Data suggest that Mst4 (zeige MST4 Antikörper) phosphorylation of Thr545 of Acap4/Asap3 (zeige ASAP3 Antikörper) in parietal cells leads to Acap4/Asap3 (zeige ASAP3 Antikörper) binding to Ser66-phosphorylated ezrin (a cytoskeletal protein (zeige ACTN1 Antikörper)); phosphorylation of Thr545 of Acap4/Asap3 (zeige ASAP3 Antikörper) is required for relocation of H,K-ATPase (zeige ATP1A1 Antikörper) to apical plasma membrane and acid secretion by parietal cells. (Mst4 (zeige MST4 Antikörper) = serine/threonine-protein kinase Mst4 (zeige MST4 Antikörper); Acap4/Asap3 (zeige ASAP3 Antikörper) = GTPase-activating protein (zeige RASA1 Antikörper) Acap4/Asap3 (zeige ASAP3 Antikörper))

2. Spatial control of proton pump H,K-ATPase (zeige ATP1A1 Antikörper) docking at the apical membrane by phosphorylation-coupled ezrin-syntaxin 3 (zeige STX3 Antikörper) interaction.

3. 1) NHE3 (zeige SLC9A3 Antikörper) basal activity is regulated by a signaling complex that is controlled by sequential effects of two kinases, Akt (zeige AKT1 Antikörper) and GSK-3, which act on a Ser (zeige SIGLEC1 Antikörper) cluster in the same NHE3 (zeige SLC9A3 Antikörper) C-terminal domain that binds ezrin

4. Ezrin-mediated F-actin interaction with the epithelial cell may direct membrane recruitment and cytoskeletal surface extension.

5. relatively high turnover of ezrin T567 phosphorylation was observed in all three epithelia (gastric, kidney and intestine).

Cow (Bovine) Ezrin (EZR) Interaktionspartner

1. Ezrin and CK18 (zeige KRT18 Antikörper) are downregulated during implantation in cattle. The expression changes represent a temporal depolarization, which could be important for an establishment of bovine pregnancy.

2. Ezrin-dependent, membrane-specific translocation and activation of calpain by VEGF (zeige VEGFA Antikörper) precedes AMPK (zeige PRKAA1 Antikörper) and AKT (zeige AKT1 Antikörper)-dependent phosphorylation of eNOSs1179 and production of NO.

Mouse (Murine) Ezrin (EZR) Interaktionspartner

1. Inactivation of SHIP2 (zeige INPPL1 Antikörper) leads to increased microvilli formation and solute reabsorption by the renal proximal tubule and was associated with hyperactivated ezrin/radixin/moesin (zeige MSN Antikörper) proteins and increased Rho-GTP (zeige AK3 Antikörper).

2. high actin-ezrin intensity area restricts the lateral movement of B cell receptors upon stimulation, reducing receptor clustering and signaling

3. Ezrin may play a role in regulating lymphatic metastasis in hepatocellular carcinoma and might be inversely associated with A7 expression.

4. Augmented hypertension-induced glomerular capillary injury in mice lacking CLIC5 results from abrogation of Rac1-dependent Pak and ezrin activation, perhaps reducing the tensile strength of the podocyte actin cytoskeleton.

5. Data, including data from studies in knockout mice, suggest that VDR (vitamin D receptor) regulates expression of ezrin in enterocytes; VDR appears not to be involved in morphology of tight junctions and absorption of large molecules in enterocytes.

6. Lack of ezrin not only causes achlorhydria and hypergastrinemia but also changes the structure of gastric glands, with severe perturbation of the secretory membranes of parietal cells.

7. our study demonstrates that ezrin is a novel regulator of IL-10 (zeige IL10 Antikörper) production by B cells

8. Merlin (zeige NF2 Antikörper) and Ezrin are components of a mechanism where mechanical forces associated with cell junctions are transduced across the cell cortex via cortical actomyosin cytoskeleton to control lateral mobility and activity of epidermal growth factor receptor (zeige EGFR Antikörper).

9. Dysfunction of ezrin mimics important aspects of the pathological mechanisms responsible for cholangiopathies

10. We hypothesize that polyvalent electrostatic interactions are responsible for the assembly of CD44 (zeige CD44 Antikörper) clusters and the multimeric PIP2-CD44 (zeige CD44 Antikörper)-Ezrin complexes.

Pig (Porcine) Ezrin (EZR) Interaktionspartner

1. The cytoskeletal linker protein (zeige LAT Antikörper) ezrin plays a significant role in hypothermic preservation injury in renal epithelia.

2. Coexpression of ezrin with Eps8 promotes the formation of membrane ruffles and tufts of microvilli, whereas expression of ezrin and Eps8L1a induces the clustering of actin-containing structures at the cell surface.

3. These findings reveal that direct ezrin interactions promote PTH1R apical localization and signaling in LLC-PK1 cells.

Xenopus laevis Ezrin (EZR) Interaktionspartner

1. ELMO-DOCK1 (zeige DOCK1 Antikörper), a bipartite guanine nucleotide exchange factor (zeige ARHGEF12 Antikörper) complex for the small GTPase (zeige RACGAP1 Antikörper) Rac1, and for the membrane-cytoskeletal linker Ezrin, regulates centriole/basal body migration, docking and spacing.