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Human Monoclonal CENPE Primary Antibody für ICC, FACS - ABIN108562
Yen, Compton, Wise, Zinkowski, Brinkley, Earnshaw, Cleveland: CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase. in The EMBO journal 1991
Show all 10 Pubmed References
Human Monoclonal CENPE Primary Antibody für ICC, FACS - ABIN108563
Chang, Coughlin, Mitchison: Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function. in Nature cell biology 2005
Show all 10 Pubmed References
Exacerbating chromosome missegregation in CENP-E+/- mice by reducing levels of another mitotic checkpoint component (zeige BUB3 Antikörper), Mad2 (zeige MXI1 Antikörper), results in elevated cell death and decreased tumor formation compared with reduction of either protein alone.
CENP-E stabilises BubR1 (zeige BUB1B Antikörper), thereby impacting meiosis I progression, and mediates bi-orientation by promoting kinetochore reorientation and preventing chromosomal drift towards the poles.
results suggest that CENP-E is implicated in the spindle checkpoint, and in chromosome alignment, during the two meiotic divisions in vertebrate males
Deletion of the mouse gene CENP-E causes unstable kinetochore-microtubule capture and chromosomal instability. (CENP-E)
Shugoshin 2 (zeige SGOL2 Antikörper) is necessary for the loading of MCAK (zeige KIF2C Antikörper) at the inner centromere, but is dispensable for the loading of the outer kinetochore proteins BubR1 (zeige BUB1B Antikörper) and CENP-E.
CENP-E motor activity appears to play important roles in the organization of midbody proteins to complete cytokinetic abscission.
Data indicate that three genes, KIF14 (zeige KIF14 Antikörper), NCAPG (zeige NCAPG Antikörper) and CENPE that were upregulated in Pediatric high-grade gliomas (pHGGs) and were direct miR (zeige MLXIP Antikörper)-137 or miR (zeige MLXIP Antikörper)-6500-3p targets.
CENPE was regulated by the co-binding of LSD1 (zeige KDM1A Antikörper) and AR to its promoter, which was associated with loss of RB1 (zeige RB1 Antikörper) in CRPC.
these results support a novel function of XAB2 (zeige XAB2 Antikörper) in mitotic cell cycle regulation, which is partially mediated by transcription regulation on CENPE.
CTCF (zeige CTCF Antikörper) helps recruit CENP-E to the centromere during mitosis and that it may do so through a structure stabilized by the CTCF (zeige CTCF Antikörper)/CENP-E complex.
Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules.
CENP-Q (zeige CENPQ Antikörper) - a subunit of the CENP-O (zeige CENPO Antikörper) complex (comprising CENP-O (zeige CENPO Antikörper), CENP-P (zeige CENPP Antikörper), CENP-Q (zeige CENPQ Antikörper) and CENP-U (zeige MLF1IP Antikörper)) that targets polo-like kinase (Plk1 (zeige PLK1 Antikörper)) to kinetochores - is also required for the recruitment of CENP-E to kinetochores.
CENP-E-driven chromosome congression is guided by microtubule detyrosination.
CENP-E expression is highest in basal-like subtype among breast cancer patients.
An unexpected role of CENP-E elongated stalk in ensuring stability of kinetochore-microtubule attachments during chromosome congression and segregation.
Centrosome-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation.
centromere protein E, 312kDa
, centromere protein E - 312kD
, centromere-associated protein E
, N-7 kinesin
, centromere autoantigen E
, centromeric protein E
, kinesin 10
, kinesin superfamily protein 10
, motor domain of KIF10
, Centromere autoantigen E (312kD)
, kinesin family member 10
, kinesin-related protein CENPE
, protein phosphatase 1, regulatory subunit 61