LGMN Produkte
(Legumain (LGMN))
Kategorien
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008].
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Ausgewählte LGMN Kategorien
LGMN Antikörper
High quality antibodies with extensive validation data.
LGMN ELISA Kits
Reliable ELISA kits for a wide range of species.
LGMN Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene LGMN Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IP, ICC
Validierungen
- (8)
Kat. Nr.
ABIN7435007
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Mouse
Applikation
WB, IHC, IP, ICC
Validierungen
- (7)
Kat. Nr.
ABIN7440881
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, FACS, IHC (p)
Validierungen
- (5)
Kat. Nr.
ABIN750958
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene LGMN ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Cow
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6968243
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6957427
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6957428
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene LGMN Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse
Source
HEK-293 Cells
Validierungen
- (2)
Kat. Nr.
ABIN7275145
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (1)
Kat. Nr.
ABIN7275144
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7123739
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren LGMN Produkten
: "Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease." in: Nature communications, Vol. 6, pp. 8762, (2015) (PubMed).: "Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia." in: Molecular and cellular biology, Vol. 35, Issue 9, pp. 1491-505, (2015) (PubMed).
: "Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage." in: Cell research, Vol. 24, Issue 3, pp. 344-58, (2014) (PubMed).
: "Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment." in: Nature communications, Vol. 5, pp. 4280, (2014) (PubMed).
: "Degradation of acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, by legumain in the mouse kidney." in: Biochemical and biophysical research communications, Vol. 453, Issue 3, pp. 631-5, (2014) (PubMed).
: "Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease." in: The Journal of biological chemistry, Vol. 288, Issue 24, pp. 17495-507, (2013) (PubMed).
: "Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 23, pp. 9053-8, (2012) (PubMed).
: "Targeting cell surface alpha(v)beta(3) integrin increases therapeutic efficacies of a legumain protease-activated auristatin prodrug." in: Molecular pharmaceutics, Vol. 9, Issue 1, pp. 168-75, (2012) (PubMed).
: "Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis." in: Atherosclerosis, Vol. 201, Issue 1, pp. 53-66, (2009) (PubMed).
: "Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase." in: Molecular cell, Vol. 29, Issue 6, pp. 665-78, (2008) (PubMed).
Synonyme und alternative Namen zu LGMN
legumain (LGMN), legumain (Lgmn), legumain L homeolog (lgmn.L), legumain (lgmn), delta vacuolar processing enzyme (DELTA-VPE), legumain (MBOO_RS07785), Legumain (Odosp_3582), legumain (LOC569153), AEP, AI746452, AU022324, cb173, cb460, DELTA VACUOLAR PROCESSING ENZYME, delta vacuolar processing enzyme, DELTAVPE, lgmn, LGMN1, MGC64351, MGC88980, PRSC1, Prsc1, sb:cb173, wu:fa98g05, wu:fj92g08, zgc:76953Bezeichner auf Proteinebene für LGMN
- asparaginyl endopeptidase
- cysteine protease 1
- protease, cysteine 1
- protease, cysteine, 1 (legumain)
- preprolegumain
- protease, cysteine, 1
- legumain
- Legumain
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