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Human MBL2 Protein expressed in CHO Cells - ABIN2002787
Super, Gillies, Foley, Sastry, Schweinle, Silverman, Ezekowitz: Distinct and overlapping functions of allelic forms of human mannose binding protein. in Nature genetics 1993
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he carrying of MBL2 exon 1 codon 54 variant allele (B) was shown to be a risk factor for Recurrent vulvovaginal candidiasis in childbearing women.
Positive correlation of MBL levels with anti-ds DNA titers in systemic lupus erythematosus suggest that its values vary with activity and could be a potential biomarker of the disease.
The -221G>C polymorphism of MBL2, the -159C>T polymorphism of CD14 (zeige NDUFA2 Proteine) and the TNF (zeige TNF Proteine)-857 polymorphism of TNF-a (zeige TNF Proteine) are risk factors for spinal spinal tuberculosis (TB) and may be involved in the development of spinal TB in the Chinese population. These factors are indicators of susceptibility to spinal TB and require clinical attention.
MBL2 protein blood level was significantly reduced in the hepatocellular carcinoma patients.The association in MBL2 polymorphisms and the risk of hepatocellular carcinoma.
Results suggested the involvement of MBL2 (rs1800450) polymorphism and its protein in rheumatic heart disease pathogenesis.
MBL deficiency was significantly more frequent in the juvenile idiopathic arthritis Yersinia-reactive antibodies-positive group than in patients without Yersinia-reactive antibodies or in controls
it can be concluded that molecular analysis of MBL rs1800450 AA genotype and TNF-alpha (zeige TNF Proteine) rs1800620 AA genotype is important in the early detection and treatment of T2DM with H. pylori cagA (zeige S100A8 Proteine)(+) infection.
The results suggest that MBL deficiency and the presence of MBL2 gene polymorphisms that lead to MBL deficiency are risk factors for the occurrence of miscarriage in patients with RA.
These results suggest that the MBL2 gene Codon 54 and TNF-alpha (zeige TNF Proteine) gene G308A polymorphisms are not associated with an increased risk for development of tuberculosis in our patients.
Studies results provide evidence that Crohn's disease patients have an impairment in mannose-binding lectin-mannose-associated serine protease functional activity and that this defect is associated with mannose-binding lectin 2 and NOD2 variants.
MBL2 polymorphisms were associated with some disease groups and with the presence of some etiologic agents
MBL1 was also found to be expressed in the lung, testis and brain, whereas low expression of MBL2 was detected in the testis and kidney.
Single nucleotide polymorphisms in MBL2 at exon 1 were detected using polymerase chain reaction single-strand conformation polymorphism analysis and DNA sequencing techniques in 825 Chinese Holstein cows.
the relationship between the variants of the bovine MBL2 gene and milk production traits, mastitis, serum MBL-C levels and hemolytic complement activity in both classical pathway (CH50) and alternative pathway (ACH50) in Chinese Holstein cattle
this study shows that MBL-C expression is induced in the gut (zeige GUSB Proteine) in response to Candida albicans sensing and is required for intestinal homeostasis and host defense against Candida albicans
Targeted deletion of Mbl1/2 causes differential levels of inflammation-related gene sets at baseline and after exposure to ozone and significantly reduces pulmonary inflammation, thus indicating an important innate immunomodulatory role of the Mbl1/2 genes.
Human and murine data together indicate that SP-A, SP-D and MBL are synthesized in early gestational tissues, and may contribute to regulation of immune response at the feto-maternal interface during pregnancy.
These data show that modulation of MBL is involved in the protection against renal I/RI induced by dietary restriction, and suggest that the mechanisms of protection induced by dietary restriction and fasting may be different.
ALI in H5N1-infected mice was caused by excessive complement activation, as demonstrated by deposition of C3, C5b-9, and MBL-C in lung tissue, and by up-regulation of MBL-associated serine protease-2 (zeige MASP2 Proteine) and the complement receptors C3aR (zeige C3AR1 Proteine) and C5aR (zeige C5AR1 Proteine).
demonstrate that apolipoprotein E (Apoe (zeige APOE Proteine)), mannose-binding lectin 2 (Mbl2), and parotid secretory protein (Psp) are present at significantly different quantities in depleted plasma of diabetic NZO mice compared to non-diabetic controls
Data indicate that no change of mannan-binding lectin MBL-A during the study, however, mannan-binding lectin MBL-C concentration increased in median by 3.6-fold (2.9; 4.5-fold) during the study in the diabetic group.
These observations point to a previously unappreciated role for MBL in regulating host resistance and cardiac inflammation during infection with a major human pathogen.
MBL plays a key role in clearing influenza A virus and maintaining lung homeostasis.
Data show that genetically defined MBL-deficiency is associated with a better outcome after acute stroke.
MBL binding can be inhibited by at least two separate and independent mechanisms.
report multiple copies of MBL-like genes, with up to three copies tightly linked within a cluster spanning approximately 15 kb on chromosome 2
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases.
, mannan-binding lectin
, mannose-binding lectin (protein C) 2, soluble (opsonic defect)
, mannose-binding lectin 2, soluble (opsonic defect)
, mannose-binding protein C
, 27 kDa mannan-binding protein monomeric subunit
, mannose-binding lectin 2, soluble
, Mannose-binding protein C
, c-type lectin
, mannose binding lectin, liver (A)
, mannose-binding lectin 2
, soluble mannose-binding lectin
, mannan-binding protein
, RA-reactive factor P28A subunit
, mannose binding lectin 2 (protein C)
, mannose-binding protein C (liver)
, ra-reactive factor polysaccharide-binding component p28A
, raRF p28A
, mannose binding lectin (C)
, mannose binding lectin, liver (C)
, mannose-binding lectin (protein C) 2, soluble
, Mannan-binding protein
, Mannose-binding lectin
, hexose-binding lectin 3
, mannose binding lectin 2
, mannose binding-like lectin