MASP1 Proteine (MASP1)

Mannan-Binding Lectin serine Peptidase 1 (C4/C2 Activating Component of Ra-Reactive Factor) Proteine (MASP1)
Auf finden Sie aktuell 22 Mannan-Binding Lectin serine Peptidase 1 (C4/C2 Activating Component of Ra-Reactive Factor) (MASP1) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MASP1 Antikörper (75) und MASP1 Kits (19) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 124 MASP1 Produkte verfügbar.
3MC1, AW048060, CCPII, CRARF, CRARF1, MAP1, MAp44, MASP, Masp1/3, MASP3, PRSS5, RaRF
alle Proteine anzeigen Gen GeneID UniProt
MASP1 17174 P98064
MASP1 5648 P48740

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Mouse (Murine) Mannan-Binding Lectin serine Peptidase 1 (C4/C2 Activating Component of Ra-Reactive Factor) (MASP1) Interaktionspartner

  1. MBL (zeige MBL2 Proteine)-KO (Figure 1a) and MASP-1-KO (Figure 1b) mice are poor mobilizers in response to mobilizing agents compared with WT littermates

  2. this study shows that inhibition of MASP-1/3 by gene silencing is sufficient to ameliorate collagen Ab-induced arthritis in mice

  3. MASP-1 plasma levels were higher among patients with type 2 diabetes and diabetic mice

  4. study provides conclusive evidence that an intact complement LP is essential to initiate CAIA, and that MAp44 may be an appropriate treatment for inflammatory arthritis.

  5. Data indicate that co-deficiency of factor H (FH (zeige CFH Proteine)) and MASP-1/MASP-3 did not ameliorate either the plasma Complement C3 (zeige C3 Proteine) (C3) activation or glomerular C3 accumulation in FH-deficient mice.

  6. Within the mannose-binding lectin (zeige MBL2 Proteine)/MASP complex, MASP-1 is the necessary complement component for thrombin (zeige F2 Proteine)-like activity in vitro.

  7. We conclude that MASP-1 does not require binding to mannose binding lectins or ficolins to activate the alternative pathway of complement

  8. we investigated the mechanism of MASP-3 activation and its substrate using the recombinant mouse MASP-3 (rMASP-3) and several different types of MASP-deficient mice

  9. Our studies demonstrate for the first time, to our knowledge, the absolute requirement for the activity of MASP-1 protein in autoimmune-associated inflammatory tissue injury

  10. MASP-1 converted pro-Df to the active form in vitro, although the activation mechanism of pro-Df by MASP-1 is still unclear. Thus, it is clear that MASP-1 is an essential protease of both the lectin and alternative complement pathways.

Human Mannan-Binding Lectin serine Peptidase 1 (C4/C2 Activating Component of Ra-Reactive Factor) (MASP1) Interaktionspartner

  1. Our finding suggests that complement MASP-1 can increase adhesion between neutrophils and endothelial cells in a direct fashion

  2. Study discovered novel and independent associations of prediabetes and related traits with MASP1, and some evidence for associations with THBS1 (zeige THBS1 Proteine), GPLD1 (zeige GPLD1 Proteine) and ApoA-IV (zeige APOA4 Proteine), suggesting a role for these proteins in the pathophysiology of type 2 diabetes.

  3. MASP-1 plasma levels were higher among patients with type 2 diabetes and diabetic mice

  4. MASP-1 was not associated with adverse cardiovascular outcomes in diabetics.

  5. high serum CL-L1 (zeige COLEC10 Proteine) concentration in critically ill children upon PICU admission is associated with an increased risk of infection and prolonged need of intensive care, and counteracts the protective effect of having a high MASP-3 concentration

  6. The exclusion of the MASP1 and COLEC11 (zeige COLEC11 Proteine) Loci in two individuals from different consanguineous families and the absence of mutations in four further individuals sequenced for both genes raises the possibility that that there is further genetic heterogeneity of 3MC syndrome

  7. Plasma MASP-1 concentration at the early stage of Kawasaki disease is predictive of length of time of recovery from coronary artery lesions.

  8. MASP-1 and MASP-2 (zeige MASP2 Proteine) are activated during blood clotting. This activation is triggered by activated platelets and by the generation of fibrin during thrombotic reactions in vitro and in vivo, and may represent a novel activation/amplification mechanism in thromboinflammation.

  9. described for the first time a detailed model of prothrombin (zeige F2 Proteine) activation by MASP-1

  10. Fusion of MAP-1 with FH domains represents a novel therapeutic approach for selective targeting upstream and central complement activation at sites of inflammation

MASP1 Protein Überblick

Protein Überblick

This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with MASP1

  • mannan-binding lectin serine peptidase 1 (Masp1)
  • mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1)
  • 3MC1 Protein
  • AW048060 Protein
  • CCPII Protein
  • CRARF Protein
  • CRARF1 Protein
  • MAP1 Protein
  • MAp44 Protein
  • MASP Protein
  • Masp1/3 Protein
  • MASP3 Protein
  • PRSS5 Protein
  • RaRF Protein

Bezeichner auf Proteinebene für MASP1

MASP-1 , complement factor MASP-3 , complement-activating component of Ra-reactive factor , mannan-binding lectin serine protease 1 , mannose-binding lectin-associated serine protease 1 , mannose-binding protein-associated serine protease , ra-reactive factor serine protease p100 , raRF , serine protease 5 , Ra-reactive factor serine protease p100

17174 Mus musculus
5648 Homo sapiens
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