FCN1 Proteine (FCN1)

Ficolin (Collagen/fibrinogen Domain Containing) 1 Proteine (FCN1)
Auf www.antikoerper-online.de finden Sie aktuell 14 Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) Proteine von 7 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen FCN1 Antikörper (91) und FCN1 Kits (37) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 155 FCN1 Produkte verfügbar.
Fcn1, FCN2, Fcna, FCNB, FCNM
alle Proteine anzeigen Gen GeneID UniProt
FCN1 2219 O00602
FCN1 83517  
FCN1 14133 O70165

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Am meisten referenzierte FCN1 Proteine

  1. Human FCN1 Protein expressed in Human Cells - ABIN2003613 : Endo, Liu, Kanno, Takahashi, Matsushita, Fujita: Identification of the mouse H-ficolin gene as a pseudogene and orthology between mouse ficolins A/B and human L-/M-ficolins. in Genomics 2004 (PubMed)
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Weitere Proteine zu FCN1 Interaktionspartnern

Human Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) Interaktionspartner

  1. in northeastern Brazilian children and adolescents, FCN1 rs1071583 SNP was correlated with earlier age of type 1 diabetes mellitus (T1D) diagnosis; the SNP combination rs2989727 and rs1071583 was involved with T1D protection

  2. Ficolin-1 could provide an alternative receptor-mediated mechanism for enhancing Ebola Virus infection, thereby contributing to viral subversion of the host innate immune system.

  3. systemic lupus erythematosus patients with high ficolin-1 plasma levels had an increased risk of end-stage renal disease; there was no significant association between ficolin-1 and ficolin-3 (zeige FCN3 Proteine) with lupus nephritis

  4. Ficolin-1 was decreased in patients compared with controls measured at 6 h (median 0.13 vs 0.33 mug/ml, respectively, p < 0.0001). At 48 h, ficolin-1 was significantly higher

  5. Data indicate differences in the plasma concentrations of collectin liver 1 (zeige COLEC10 Proteine) and collectin (zeige MBL2 Proteine) kidney 1 (zeige ZNF354A Proteine), M-ficolin and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls.

  6. This study aims to investigate whether an association exists between the ficolins that are part of the lectin complement pathway and systemic lupus erythematosus.

  7. the differential binding of ficolin-1 to lymphocyte subsets suggests ficolin-1 as a novel link between innate and adaptive immunity.

  8. In patients with early rheumatoid arthritis, elevated plasma M-ficolin levels correlated with a high disease activity score at baseline and 1 year. A low M-ficolin level was the strongest predictor of remission and low disease activity.

  9. Data show that a photodynamic therapy (PDT (zeige TWIST1 Proteine)) dose-dependent upregulation of CRP (zeige CRP Proteine) gene, as well as of PTX3 (zeige PITX3 Proteine) and ficolin 1 genes in lung tumor A549 cells, and indicate critical role played by PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine)/AP-1 (zeige FOSB Proteine) pathway.

  10. These results demonstrate that ficolin-1 and PTX3 (zeige PITX3 Proteine) heterocomplex formation acts as a noninflammatory "find me and eat me" signal to sequester altered-host cells.

Mouse (Murine) Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) Interaktionspartner

  1. this study shows that FCN-A/2 exacerbated the inflammatory pathogenesis of inflammatory bowel disease by stimulating M1 polarization through the TLR4 (zeige TLR4 Proteine)/MyD88 (zeige MYD88 Proteine)/MAPK (zeige MAPK1 Proteine)/NF-kappaB (zeige NFKB1 Proteine) signalling pathway in macrophages

  2. FcnA-deficient and FcnA/ficolin B double-deficient mice lack FcnA-mediated complement activation in the sera, because of absence of complexes comprising FcnA and MBL-associated serine proteases.

  3. the binding properties of the murine serum ficolin-A towards a panel of different clinical relevant microorganisms

  4. binds to the glycoproteins hemagglutinin (zeige HA Proteine) and neuraminidase (zeige NEU Proteine) and inhibits influenza A virus infection both in vitro and in vivo

  5. Recombinant mouse ficolin A, mannose-binding lectin-A, and mannose-binding lectin-C bound to fibrinogen in a dose-dependent manner. The lectin pathway, through mannose-binding lectins, synchronized with blood coagulation.

  6. the expression pattern of ficolin A expression was closely similar to that of mannose-binding lectin-associated serine proteases, suggesting that these molecules may function in coordination as components of the lectin complement pathway

  7. Ficolin A protein (smapshowed a potent complement activating capacity.These results suggest that ficolin A and its variant function as recognition molecules of the lectin pathway.

  8. A functionally relevant signal peptide of ficolin A was identified by using mass spectrometry analysis to determine the N-terminal sequence of secreted ficolin A.

FCN1 Protein Überblick

Protein Überblick

The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity.

Alternative names and synonyms associated with FCN1

  • ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) (FCN2)
  • ficolin (collagen/fibrinogen domain containing) 1 (FCN1)
  • ficolin (collagen/fibrinogen domain containing) 1 (Fcn1)
  • ficolin A (Fcna)
  • Fcn1 Protein
  • FCN2 Protein
  • Fcna Protein
  • FCNB Protein
  • FCNM Protein

Bezeichner auf Proteinebene für FCN1

ficolin 1 , M-ficolin , collagen/fibrinogen domain-containing protein 1 , ficolin (collagen/fibrinogen domain-containing) 1 , ficolin-1 , ficolin-A , ficolin-alpha , ficolin B , L-ficolin , collagen/fibrinogen domain-containing protein 2 , ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) , ficolin 2 , ficolin-2 , ficolin-B , ficolin-beta , ficolin A

417298 Gallus gallus
2219 Homo sapiens
397316 Sus scrofa
497016 Bos taurus
83517 Rattus norvegicus
100724936 Cavia porcellus
14133 Mus musculus
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