C5A Proteine (C5a)

Bezeichnung:: Complement Component 5a Proteine (C5a)

Auf www.antikoerper-online.de finden Sie aktuell 21 Complement Component 5a (C5a) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen C5A Kits (104) und C5A Antikörper (60) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 186 C5A Produkte verfügbar.

Synonyme:: C5a, C5b, CPAMD4, Hc, RGD1561905

alle Proteine anzeigen	Gen	GeneID	UniProt
	C5a	727	P01031
	C5a	362119
	C5a
Weitere Synonyme anzeigen

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Verknüpfte Pathways mit C5A Proteine

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Am meisten referenzierte C5A Proteine

Human C5A Protein expressed in Escherichia coli (E. coli) - ABIN2506921 : Yang, Radu, Wang, Riedinger, Witte: Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A. in Blood 2005 (PubMed)
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Mouse (Murine) C5A Protein expressed in Escherichia coli (E. coli) - ABIN413104 : Jun, Lee, Song, Mansfield, Chou: G-CSF improves murine G6PC3-deficient neutrophil function by modulating apoptosis and energy homeostasis. in Blood 2011 (PubMed)
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Human C5A Protein expressed in Escherichia coli (E. coli) - ABIN413098 : Nonaka, Bao, Matsumura, Götze, Kandasamy, Kononov, Broide, Nakayama, Seeberger, Fukuda: Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites. in Proceedings of the National Academy of Sciences of the United States of America 2014 (PubMed)
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Weitere Proteine zu C5A Interaktionspartnern

Human Complement Component 5a (C5a) Interaktionspartner

recombinant C5a potentiated TNFalpha (zeige TNF Proteine)-induced NF-kappaB (zeige NFKB1 Proteine) activation in renal tubular epithelial cells
tumoral C5a is an independent adverse prognostic biomarker for clinical outcome of Clear Cell Renal Cell Carcinoma (zeige MOK Proteine) patients after nephectomy.
C5a synergises with P. aeruginosa LPS (zeige IRF6 Proteine) in both PD-L1 (zeige CD274 Proteine) expression and the production of IL-10 (zeige IL10 Proteine) and TGF-beta (zeige TGFB1 Proteine).
Up-regulation of granulocyte and monocyte CD11b (zeige ITGAM Proteine) during plasma separation was C5-dependent.
This study provides the preclinical rationale for the combined blockade of PD-1 (zeige PDCD1 Proteine)/PD-L1 (zeige CD274 Proteine) and C5a to restore antitumor immune responses, inhibit tumor cell growth, and improve outcomes of patients with lung cancer
Diagnosis and therapeutic management of neonatal hemochromatosis (zeige HFE Proteine) cannot only be based on C5b9 expression in liver samples as it is not specific of this disease.
C5a-C5aR enriched clear cell renal cell carcinoma (zeige MOK Proteine) patients significantly had a poorer overall survival and recurrence free survival after nephrectomy.
The complement activation factors Bb, C3a, C5a, and MAC were increased significantly in early-onset severe pre-eclampsia (EOSPE) (all P<.01) and late-onset severe pre-eclampsia (LOSPE). (P value: .027, <.001, .001, and <.001, respectively) compared with E/L-control. C1q and C4d were increased significantly in LOSPE (P value: .003 and .014, respectively) compared with L-control.
C5a/C5aR pathway promotes gastric cancer pathogenesis by suppressing p21 (zeige CDKN1A Proteine)/p-p21 (zeige CDKN1A Proteine) expression via activation of PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) signaling.
Studies indicate that the complement response lie the active fragments, C3a (zeige C3 Proteine) and C5a, acting through their specific receptors, C3aR (zeige C3AR1 Proteine), C5aR1 (zeige C5AR1 Proteine) and C5aR2 to direct the cellular response to inflammation.

C5A (C5a) Protein Überblick

Protein Überblick

The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.

Alternative names and synonyms associated with C5A (C5a)

complement C5 (C5)

C5a Protein
C5b Protein
CPAMD4 Protein
Hc Protein
RGD1561905 Protein

Bezeichner auf Proteinebene für Complement Component 5a Proteine (C5a)

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 , C5a anaphylatoxin , anaphylatoxin C5a analog , complement C5 , prepro-C5 , anaphylatoxin

GENE ID	SPEZIES
727	Homo sapiens
362119	Rattus norvegicus

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Show all Complement Component 5a Proteine (C5a) with Pubmed References

Human Complement Component 5a (C5a) Interaktionspartner

Protein Überblick

Alternative names and synonyms associated with C5A (C5a)

Bezeichner auf Proteinebene für Complement Component 5a Proteine (C5a)