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Human C5A Protein expressed in Escherichia coli (E. coli) - ABIN413098 : Nonaka, Bao, Matsumura, Götze, Kandasamy, Kononov, Broide, Nakayama, Seeberger, Fukuda: Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites. in Proceedings of the National Academy of Sciences of the United States of America 2014 (PubMed) Show all 2 Pubmed References
Mouse (Murine) C5A Protein expressed in Escherichia coli (E. coli) - ABIN413104 : Jun, Lee, Song, Mansfield, Chou: G-CSF improves murine G6PC3-deficient neutrophil function by modulating apoptosis and energy homeostasis. in Blood 2011 (PubMed) Show all 2 Pubmed References
Human C5A Protein expressed in Escherichia coli (E. coli) - ABIN2506921 : Yang, Radu, Wang, Riedinger, Witte: Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A. in Blood 2005 (PubMed) Show all 2 Pubmed References
This study provides the preclinical rationale for the combined blockade of PD-1 (zeige PDCD1 Proteine)/PD-L1 (zeige CD274 Proteine) and C5a to restore antitumor immune responses, inhibit tumor cell growth, and improve outcomes of patients with lung cancer
Diagnosis and therapeutic management of neonatal hemochromatosis (zeige HFE Proteine) cannot only be based on C5b9 expression in liver samples as it is not specific of this disease.
C5a-C5aR enriched clear cell renal cell carcinoma (zeige MOK Proteine) patients significantly had a poorer overall survival and recurrence free survival after nephrectomy.
The complement activation factors Bb, C3a, C5a, and MAC were increased significantly in early-onset severe pre-eclampsia (EOSPE) (all P<.01) and late-onset severe pre-eclampsia (LOSPE). (P value: .027, <.001, .001, and <.001, respectively) compared with E/L-control. C1q and C4d were increased significantly in LOSPE (P value: .003 and .014, respectively) compared with L-control.
C5a/C5aR pathway promotes gastric cancer pathogenesis by suppressing p21 (zeige CDKN1A Proteine)/p-p21 (zeige CDKN1A Proteine) expression via activation of PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) signaling.
Studies indicate that the complement response lie the active fragments, C3a (zeige C3 Proteine) and C5a, acting through their specific receptors, C3aR (zeige C3AR1 Proteine), C5aR1 (zeige C5AR1 Proteine) and C5aR2 to direct the cellular response to inflammation.
Data show the expression of a neoepitope which was exposed on complement C5 (zeige C5 Proteine) (C5) after binding to eculizumab in vivo.
data indicate that properdin enhances platelet/granulocyte aggregates (PGAs) formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation
Increased C5a expression is associated with increased inflammation in cystic fibrosis (zeige S100A8 Proteine).
The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 , C5a anaphylatoxin , anaphylatoxin C5a analog , complement C5 , prepro-C5 , anaphylatoxin