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Kallikrein 6 ELISA Kit

KLK6 Reaktivität: Human Colorimetric Sandwich ELISA 78 pg/mL - 5000 pg/mL Cell Culture Lysate, Cell Culture Supernatant, Plasma (EDTA - heparin), Serum, Tissue Homogenate
Produktnummer ABIN6719698
$529.00
Zzgl. Versandkosten $45.00
1 kit
Lieferung in 1 bis 2 Werktagen
  • Target Alle Kallikrein 6 (KLK6) ELISA Kits anzeigen
    Kallikrein 6 (KLK6)
    Reaktivität
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Nachweismethode
    Colorimetric
    Methodentyp
    Sandwich ELISA
    Detektionsbereich
    78 pg/mL - 5000 pg/mL
    Untere Nachweisgrenze
    78 pg/mL
    Applikation
    ELISA
    Verwendungszweck
    Sandwich ELISA for Quantitative Detection of Antigen
    Proben
    Cell Culture Lysate, Cell Culture Supernatant, Plasma (EDTA - heparin), Serum, Tissue Homogenate
    Analytische Methode
    Quantitative
    Produktmerkmale

    Synonyms: Kallikrein-6, Klk6, KLK6_HUMAN, Neurosin, Protease M, Serine protease 18, Serine protease 9, SP59, Zyme

    Background: KLK6(Kallikrein-related peptidase 6), also called KALLIKREIN 6, NEUROSIN, PROTEASE M, ZYME or PRSS9, is a protein that in humans is encoded by the KLK6 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. Northern blot analysis revealed that the PRSS9 mRNA was expressed in several primary tumors and cell lines from mammary, prostate, and ovarian cancers, but was not detected in any metastases of these cancers. The KLK6 gene is mapped on 19q13.41. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Upon cellular stress, neurosin was released from mitochondria to the cytosol, which resulted in the increase of degraded alpha-synuclein species. Neurosin may play a significant role in physiologic alpha-synuclein degradation and also in the pathogenesis of synucleinopathies.

    Gene Name: KLK6

    Production: Natural and recombinant human Kallikrein-6. There is no detectable cross-reactivity with other relevant proteins.

    Standard: Expression system for standard: NSO, Immunogen sequence: L22-K244

  • Applikationshinweise

    Application Note: Useful in Sandwich ELISA for Quantitative Detection of Antigen. Aliquot 0.1 mL per well of the 5000pg/mL, 2500pg/mL, 1250pg/mL, 625pg/mL, 312pg/mL, 156pg/mL, 78pg/mL human Kallikrein-6 standard solutions into the precoated 96-well plate. Add 0.1 mL of the sample diluent buffer into the control well (Zero well). Add 0.1 mL of each properly diluted sample of human cell culture supernates, cell lysates, serum, plasma(heparin, EDTA) or tissue homogenates to each empty well. We recommend that each human Kallikrein-6 standard solution and each sample is measured in duplicate.

    Blood Product Anticoagulant: Heparin Sodium

    ELISA Dilution: 78pg/mL-5000pg/mL

    Probenmenge
    100 μL
    Plattentyp
    Pre-coated
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Lagerung
    RT,4 °C,-20 °C
    Informationen zur Lagerung
    Store vials at 4°C prior to opening. Centrifuge product if not completely clear after standing at room temperature. This product is stable for 6 months at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage freeze at -20°C or below for 12 months. Avoid cycles of freezing and thawing.
  • Target Alle Kallikrein 6 (KLK6) ELISA Kits anzeigen
    Kallikrein 6 (KLK6)
    Andere Bezeichnung
    Kallikrein-6 (KLK6 Produkte)
    Synonyme
    Bssp, Klk7, PRSS18, PRSS9, SP59, hK6, Prss9, AI849898, BSP, Klk29, MSP, Prss18, neurosin, kallikrein related peptidase 6, kallikrein related-peptidase 6, kallikrein-6, KLK6, Klk6, LOC100716801
    Gen-ID
    5653
    NCBI Accession
    NP_001012982
    UniProt
    Q92876
    Pathways
    Komplementsystem, Regulation of G-Protein Coupled Receptor Protein Signaling
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