FSH ELISA Kit

Produktnummer ABIN577075

Human FSH ELISA Kit, Colorimetric Assay für die Quantifizierung von Human FSH.

Kurzübersicht für FSH ELISA Kit (ABIN577075)

Target: FSH (Follicle-Stimulating Hormone (FSH))

Reaktivität: Human

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Applikation: ELISA

Produktdetails FSH ELISA Kit

Verwendungszweck: For the quantitative determination of human follicle stimulating hormone (FSH) concentrations in serum

Analytische Methode: Quantitative

Sensitivität: The minimal detectable concentration of FSH by this assay is estimated to be 1.5 mIU/mL.

Bestandteile: Standards: 1 set/2 vials

Anwendungsinformationen

Plattentyp: Pre-coated

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konservierungsmittel: Without preservative

Details zu FSH

Target: FSH (Follicle-Stimulating Hormone (FSH))

Andere Bezeichnung: Follicle Stimulating Hormone (FSH)

Substanzklasse: Hormone

Hintergrund: Epidermal growth factor (EGF), a polypeptide mitogen, was first observed in 1959 by Cohen and Levi-Montalcini while studying Nerve Growth Factor (NGF) in snake venom extracts.1 It was subsequently isolated and purified from mouse submandibular glands. When injected into new- born mice this new factor caused precocious eyelid opening and incisor eruption.2,3 EGF was further purified, based on its ability to induce the proliferation of basal skin cells.4 Also, a potent inhibitor of gastric acid secretion was identified and isolated from the urine of a pregnant women, and named human -urogastrone. It was shown that this protein was very similar to purified human EGF.5,6 The cDNA cloning of mature EGF revealed that this polypeptide (6 kDa, 53 amino acids) belonged to a family of growth factors (TGF- , vaccinia virus growth factor and amphiregulin) that bind to the same 16-185 kDa family of cell surface receptors. Structurally EGF is homologous to TGF- .7,8,9 Mature EGF is formed when the large precursor molecule (pre-EGF), a transmembrane protein (13 kDa, 1217 amino acids) which contains at least seven EGF-like sequences is cleaved. Within this precursor molecule, it is the sequence closest to the C-terminus of the mRNA that represents the coding region for the mature, soluble EGF sequence.7,1 The uncleaved precursor shows biological activity and is capable of binding to the EGF receptor.11,12 The physiological significance of the EGF precursor, nor the mechanisms of its processing into mature EGF have yet to be illustrated. However it is a source for soluble EGF and may be involved in cell to cell signalling or

Pathways: Peptide Hormone Metabolism, Chromatin Binding