IL23R ELISA Kit

Produktnummer ABIN5510750

Dieses Human IL23R ELISA-Kit ist ein Colorimetric ELISA-Kit, das dafür entwickelt wurde, Human IL23R zu quantifizieren.

Kurzübersicht für IL23R ELISA Kit (ABIN5510750)

Target: IL23R (Interleukin 23 Receptor (IL23R))

Bindungsspezifität: AA 25-354

Reaktivität: Human

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Applikation: ELISA

Produktdetails IL23R ELISA Kit

Verwendungszweck: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human IL-23R

Marke: PicoKine™

Analytische Methode: Quantitative

Spezifität: Expression system for standard: NSO, Immunogen sequence: I25-I354

Kreuzreaktivität (Details): There is no detectable cross-reactivity with other relevant proteins.

Produktmerkmale:

Tissue Specificity: Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.

Anwendungsinformationen

Plattentyp: Pre-coated

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Haltbarkeit: 12 months

Details zu IL23R

Target: IL23R (Interleukin 23 Receptor (IL23R))

Andere Bezeichnung: IL23R

Hintergrund:

Protein Function: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Background: Interleukin-23 subunit alpha is a protein that in humans is encoded by the IL23A gene. The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.

Synonyms: Interleukin-23 receptor, IL-23 receptor, IL-23R, IL23R,

Full Gene Name: interleukin 23 receptor

Cellular Localisation: Cell membrane

UniProt: Q5VWK5

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation