IL23R ELISA Kit

Produktnummer ABIN5510751

Produktdetails IL23R ELISA Kit

Target: IL23R (Interleukin 23 Receptor (IL23R))

Bindungsspezifität: AA 25-373

Reaktivität: Maus

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Applikation: ELISA

Verwendungszweck: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse IL-23R

Marke: PicoKine™

Analytische Methode: Quantitative

Spezifität: Expression system for standard: NSO, Immunogen sequence: I25-I373

Kreuzreaktivität (Details): There is no detectable cross-reactivity with other relevant proteins.

Produktmerkmale:

Tissue Specificity: Expressed by Th1, Th2 and dendritic cells.

Anwendungsinformationen

Plattentyp: Pre-coated

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Haltbarkeit: 12 months

Referenzen für IL23R ELISA Kit (ABIN5510751)

Wang, Deng, Wang, Wu, Gu, Jiang, Li: "MicroRNA-155 in exosomes secreted from helicobacter pylori infection macrophages immunomodulates inflammatory response." in: American journal of translational research, Vol. 8, Issue 9, pp. 3700-3709, (2016) (PubMed).

Details zu IL23R

Target: IL23R (Interleukin 23 Receptor (IL23R))

Andere Bezeichnung: Il23r (IL23R Produkte)

Synonyme: IL-23R ELISA Kit, IL23R ELISA Kit, il-23r ELISA Kit, interleukin 23 receptor ELISA Kit, IL23R ELISA Kit, il23r ELISA Kit, Il23r ELISA Kit

Hintergrund:

Protein Function: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis (By similarity). .

Background: Interleukin-23 subunit alpha is a protein that in humans is encoded by the IL23A gene. The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.

Synonyms: Interleukin-23 receptor, IL-23 receptor, IL-23R, Il23r,

Full Gene Name: interleukin 23 receptor

Cellular Localisation: Cell membrane, Single-pass type I membrane protein.

UniProt: Q8K4B4

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation