ACVRL1 ELISA Kit

Produktnummer ABIN5510686

Dieses Colorimetric ELISA kit dient der quantitativen Messung von Maus ACVRL1.

Kurzübersicht für ACVRL1 ELISA Kit (ABIN5510686)

Target: ACVRL1 (Activin A Receptor Type II-Like 1 (ACVRL1))

Bindungsspezifität: AA 23-119

Reaktivität: Maus

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Applikation: ELISA

Produktdetails ACVRL1 ELISA Kit

Verwendungszweck: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse ALK-1/ACVRL1

Analytische Methode: Quantitative

Spezifität: Expression system for standard: NSO
Immunogen sequence: D23-P119

Kreuzreaktivität (Details): There is no detectable cross-reactivity with other relevant proteins.

Anwendungsinformationen

Plattentyp: Pre-coated

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Haltbarkeit: 12 months

Details zu ACVRL1

Target: ACVRL1 (Activin A Receptor Type II-Like 1 (ACVRL1))

Andere Bezeichnung: Acvrl1

Hintergrund:

Protein Function: Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. .

Background: Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ACVRL1 gene. It is also known as activin receptor-like kinase 1, or ALK1. This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.

Synonyms: Serine/threonine-protein kinase receptor R3,SKR3,2.7.11.30,Activin receptor-like kinase 1,ALK-1,TGF-B superfamily receptor type I,TSR-I,Acvrl1,Acvrlk1, Alk-1,

Full Gene Name: Serine/threonine-protein kinase receptor R3

Cellular Localisation: Cell membrane, Single-pass type I membrane protein.

UniProt: Q61288