MPL ELISA Kit

Produktnummer ABIN5510636

Dieses Maus MPL ELISA-Kit ist ein Colorimetric ELISA-Kit, das dafür entwickelt wurde, Maus MPL zu quantifizieren.

Kurzübersicht für MPL ELISA Kit (ABIN5510636)

Target: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Bindungsspezifität: AA 26-482

Reaktivität: Maus

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Applikation: ELISA

Produktdetails MPL ELISA Kit

Verwendungszweck: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse TPOR/MPL

Marke: PicoKine™

Analytische Methode: Quantitative

Spezifität: Expression system for standard: NSO
Immunogen sequence: Q26-W482

Kreuzreaktivität (Details): There is no detectable cross-reactivity with other relevant proteins.

Anwendungsinformationen

Plattentyp: Pre-coated

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Haltbarkeit: 12 months

Details zu MPL

Target: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Andere Bezeichnung: Mpl

Hintergrund:

Protein Function: Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.

Background: The thrombopoietin receptor (TPOR), also known as CD110, is a protein that in humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene. The human MPL gene is mapped to chromosome 1p34. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

Synonyms: Thrombopoietin receptor,TPO-R,Myeloproliferative leukemia protein,Proto-oncogene c-Mpl,CD110,Mpl,Tpor,

Full Gene Name: Thrombopoietin receptor

Cellular Localisation: Cell membrane, Single-pass type I membrane protein . Golgi apparatus . Cell surface.

UniProt: Q08351

Pathways: JAK-STAT Signalweg