GZMB ELISA Kit

Produktnummer ABIN5510620

Dieses Colorimetric ELISA-Kit wurde entwickelt für die quantitative Messung von Maus GZMB.

Kurzübersicht für GZMB ELISA Kit (ABIN5510620)

Target: GZMB (Granzyme B (GZMB))

Bindungsspezifität: AA 21-247

Reaktivität: Maus

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Applikation: ELISA

Produktdetails GZMB ELISA Kit

Verwendungszweck: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse Granzyme B

Marke: PicoKine™

Analytische Methode: Quantitative

Spezifität: Expression system for standard: NSO, Immunogen sequence: I21-S247

Kreuzreaktivität (Details): There is no detectable cross-reactivity with other relevant proteins.

Anwendungsinformationen

Plattentyp: Pre-coated

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Haltbarkeit: 12 months

Details zu GZMB

Target: GZMB (Granzyme B (GZMB))

Andere Bezeichnung: Gzmb

Hintergrund:

Protein Function: This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis (By similarity). .

Background: Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

Synonyms: Granzyme B(G,H),3.4.21.79,CTLA-1,Cytotoxic cell protease 1,CCP1,Fragmentin-2,Gzmb,Ctla-1, Ctla1,

Full Gene Name: Granzyme B(G,H)

Cellular Localisation: Cytoplasmic granule. Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.

UniProt: P04187

Pathways: Apoptose, Caspase Kaskade in der Apoptose