Cardiotrophin 1 ELISA Kit

Produktnummer ABIN5510574

Maus Cardiotrophin 1 ELISA-Kit Colorimetric-Assay zur Quantifizierung von Maus Cardiotrophin 1.

Kurzübersicht für Cardiotrophin 1 ELISA Kit (ABIN5510574)

Target: Cardiotrophin 1 (CTF1)

Bindungsspezifität: AA 2-203

Reaktivität: Maus

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Applikation: ELISA

Produktdetails Cardiotrophin 1 ELISA Kit

Verwendungszweck: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse Cardiotrophin-1

Marke: PicoKine™

Analytische Methode: Quantitative

Spezifität: Expression system for standard: E.coli, Immunogen sequence: S2-A203

Kreuzreaktivität (Details): There is no detectable cross-reactivity with other relevant proteins.

Produktmerkmale:

Tissue Specificity: Highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels in testis and brain. No expression in spleen.

Anwendungsinformationen

Plattentyp: Pre-coated

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Haltbarkeit: 12 months

Details zu Cardiotrophin 1

Target: Cardiotrophin 1 (CTF1)

Andere Bezeichnung: Ctf1

Hintergrund:

Protein Function: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

Background: Cardiotrophin-1 (CT-1) is a member of the family of cytokines that includes leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM), interleukin-6 (IL6), and interleukin-11 (IL11). And the CT-1 gene is mapped to 1p21-p13. The human CT-1 protein contains 201 amino acids and shares 80 % amino acid identity with the 203-amino acid mouse CT-1 sequence, however, unlike the mouse protein, human CT-1 has 2 rather than 1 cys and has no N-glycosylation site. Despite lacking a signal sequence, secreted CT-1 and mouse CT-1 induce cardiac myocyte hypertrophy in cell culture and bind to both mouse and human LIFR but not to OSMR. Furthermore, A 1.7-kb CT-1 transcript was detected at high levels in heart, skeletal muscle, prostate, and ovary. Low levels were detected in lung, kidney, pancreas, thymus, testis, and small intestine, with little or no expression detected in brain, placenta, spleen, colon, and peripheral blood leukocytes. And it was also observed strong expression in fetal lung and kidney.

Synonyms: Cardiotrophin-1, CT-1, Ctf1,

Full Gene Name: cardiotrophin 1

Cellular Localisation: Secreted.

UniProt: Q60753

Pathways: JAK-STAT Signalweg