beta Catenin ELISA Kit

Produktnummer ABIN5068366

Dieses Colorimetric ELISA-Kit wurde entwickelt für die quantitative Messung von Human beta Catenin.

Kurzübersicht für beta Catenin ELISA Kit (ABIN5068366)

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Reaktivität: Human

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Applikation: ELISA

Proben: Cell Lysate

Produktdetails beta Catenin ELISA Kit

Kreuzreaktivität (Details): Calculated cross reactivity: Hu

Produktmerkmale: Catenin, beta, Human, ELISA Kit

Bestandteile:

• 1. Microtiter Plate, Catenin antibody-coated microtiter, 1x96 wells.
• 2. Beta-Catenin Detection Ab, 1x11ml
• 3. IgG (HRP) Ab, 1x11ml
• 4. TMB Substrate, 1x 11ml
• 5. STOP Solution, 1x11ml
• 6. Wash Buffer (20X), 1x25ml
• 7. Sample Diluent, 1x25ml.
• 8. Cell Lysis Buffer, 1x15ml

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Details zu beta Catenin

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Andere Bezeichnung: Catenin, beta

Hintergrund: A key downstream effector in the Wnt signaling pathway is b-catenin (1). It is implicated in two major biological processes of vertebrates: early embryonic development (2) and tumorigenesis (3). Casein kinase 1 phosphorylates b-catenin on Ser45. This phosphorylation event primes b-catenin for subsequent phosphorylation by GSK-3 (4-6). GSK-3b destabilizes b-catenin by phosphorylating it at Ser33, 37 and Thr41 (7). Mutations in these phosphorylation sites which result in the stabilization of b-catenin protein levels have been found in many tumor cell lines (8).

Pathways: Peptide Hormone Metabolism