IL-10 ELISA Kit

Produktnummer ABIN2042518

Ratte IL-10 ELISA-Kit Colorimetric-Assay zur Quantifizierung von Ratte IL-10.

Kurzübersicht für IL-10 ELISA Kit (ABIN2042518)

Target: IL-10 (IL10) (Interleukin 10 (IL10))

Reaktivität: Ratte

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Detektionsbereich: 31.2-2000 pg/mL

Applikation: ELISA

Produktdetails IL-10 ELISA Kit

Untere Nachweisgrenze: 31.2 pg/mL

Kreuzreaktivität (Details): No detectable crossreactivity with other relevant proteins

Sensitivität: < 4 pg/mL

Bestandteile: A: Microtiter Strips, 1x96 wells
B: IL-10 Standard, 2x10 ng
C: Anti-rat IL-10 (Biotin), 130 µL

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C/-20 °C

Details zu IL-10

Target: IL-10 (IL10) (Interleukin 10 (IL10))

Andere Bezeichnung: IL-10

Hintergrund: Interleukin-10, also called cytokine synthesis inhibitory factor, is implicated in tumorigenesis, and it has been shown that polymorphisms in its gene promoter correlate with differential amounts of production (1). IL-10 is an important cytokine with anti-inflammatory, anti-immune, and antifibrotic functions (2). It is also an important regulatory cytokine whose involvement extends into diverse areas of the human immune system (3). IL-10 is a recently described natural endogenous immunosuppressive cytokine that has been identified in human, murine, and other organisms. IL-10 significantly affects chemokine biology, because human IL-10 inhibits chemokine production and is a specific chemotactic factor for CD8+ T cells. It suppresses the ability of CD4+ T cells, but not CD8+ T cells, to migrate in response to IL-8 (4). Interleukin-10 gene polymorphisms and interleukin-10 production capability may contribute to the development of skin squamous cell carcinomas after renal transplantation (1). The interleukin-10 locus contributes to the heritability of psoriasis susceptibility (5). With regard to sudden infant death, IL-10 is of special interest. This is an immunoregulatory cytokine that plays an important role in the development of infectious disease (6). The mIL-10 gene is mapped to mouse chromosome 1 and the hIL-10 gene is also mapped to human chromosome 1 (7).

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location, Cancer Immune Checkpoints