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FASL ELISA Kit

Dieses Human FASL ELISA-Kit ist ein Colorimetric ELISA-Kit, das dafür entwickelt wurde, Human FASL zu quantifizieren.
Produktnummer ABIN2042460

Kurzübersicht für FASL ELISA Kit (ABIN2042460)

Target

Alle FASL ELISA Kits anzeigen
FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))

Reaktivität

  • 10
  • 5
  • 5
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Nachweismethode

Colorimetric

Methodentyp

Competition ELISA

Detektionsbereich

15.6-1000 pg/mL

Applikation

ELISA
  • Untere Nachweisgrenze

    15.6 pg/mL

    Marke

    BioAssay™

    Kreuzreaktivität (Details)

    No detectable crossreactivity with other relevant proteins

    Sensitivität

    < 2 pg/mL

    Bestandteile

    A: Microtiter Strip, 1x96 wells
    B: FASL Standard, 2x10 ng
    C: Anti-human FASL (Biotin), 130 µL
    : Avidin-Biotin-Peroxidase Complex (ABC), 1x130 µL (1:100 dilution)
    : Sample diluent buffer, 1x30 mL
    : Antibody diluent buffer, 1x10 mL
    : ABC diluent buffer, 1x10 mL
    : TMB color developing agent, 1x10 mL
    : TMB stop solution, 2N H2SO4, 1x10 mL
  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Lagerung

    4 °C/-20 °C
  • Target Alle FASL ELISA Kits anzeigen

    FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))

    Andere Bezeichnung

    FASL

    Hintergrund

    Fas ligand (FasL or CD95L) is a type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. The human FASL gene consists of approximately 8kb and is split into 4 exons. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Fas ligand or FasL is a homotrimeric type II transmembrane protein. It signals through trimerization of FasR, which spans the membrane of the "target" cell. This trimerization usually leads to apoptosis, or cell death. Soluble Fas ligand is generated by cleaving membrane-bound FasL at a conserved cleavage site by the external matrix metalloproteinase MMP-7.

    Pathways

    Apoptose, EGFR Signaling Pathway, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
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