Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Wählen Sie die Spezies und Applikation aus
anti-Mouse (Murine) STAT3 Antikörper:
anti-Human STAT3 Antikörper:
anti-Rat (Rattus) STAT3 Antikörper:
Sie gelangen zu unserer vorgefilterten Suche.
Human Polyclonal STAT3 Primary Antibody für WB - ABIN3043299
Zheng, Liu, Liu, Ma, Zhou, Chen, Chang, Wang, Yang, He: Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH?SY5Y human neuroblastoma cells. in Molecular medicine reports 2014
Show all 14 Pubmed References
Human Polyclonal STAT3 Primary Antibody für IHC, WB - ABIN361960
Yamaguchi, Zhu, Yu, Sasaki, Umetsu, Kidachi, Ryoyama: Low-level bisphenol A increases production of glial fibrillary acidic protein in differentiating astrocyte progenitor cells through excessive STAT3 and Smad1 activation. in Toxicology 2006
Show all 9 Pubmed References
Human Polyclonal STAT3 Primary Antibody für IHC (p), WB - ABIN6652045
Fan, Ballou, Lin: Phospholipase C-independent activation of glycogen synthase kinase-3beta and C-terminal Src kinase by Galphaq. in The Journal of biological chemistry 2003
Show all 13 Pubmed References
Human Polyclonal STAT3 Primary Antibody für ICC, IHC (p) - ABIN3044166
Khan, Li, Ahmad Khan, Rasul, Nawaz, Sun, Zheng, Ma: Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction. in BioMed research international 2013
Show all 8 Pubmed References
Human Polyclonal STAT3 Primary Antibody für FACS, IF (p) - ABIN732638
Yang, Sun, Sun, Qi: Effect of suppressor of cytokine signaling 2 (SOCS2) on fat metabolism induced by growth hormone (GH) in porcine primary adipocyte. in Molecular biology reports 2012
Show all 8 Pubmed References
Human Polyclonal STAT3 Primary Antibody für WB - ABIN5518872
Wan, Ma, Mei, Shan: The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells. in Journal of experimental & clinical cancer research : CR 2010
Show all 7 Pubmed References
Human Polyclonal STAT3 Primary Antibody für IF, IHC - ABIN361962
Yamaguchi, Zhu, Yu, Sasaki, Umetsu, Kidachi, Ryoyama et al.: Serum-free mouse embryo cells generate a self-sustaining feedback loop for an astrocyte marker protein and respond to cytokines and bisphenol A in accordance with the subtle difference in their ... in Cell biology international 2007
Show all 6 Pubmed References
Human Polyclonal STAT3 Primary Antibody für WB - ABIN6713922
Zeng, Wang, Dong, Jiang, Tu: Sesquiterpene dimer (DSF-52) from Artemisia argyi inhibits microglia-mediated neuroinflammation via suppression of NF-κB, JNK/p38 MAPKs and Jak2/Stat3 signaling pathways. in Phytomedicine : international journal of phytotherapy and phytopharmacology 2014
Show all 5 Pubmed References
Human Polyclonal STAT3 Primary Antibody für IHC, WB - ABIN6711577
Wang, Deng, Leng, Mao: Interleukin-15 receptor-directed immunotoxins atteunuate disease severity in rat adjuvant arthritis. in Molecular immunology 2010
Show all 5 Pubmed References
Ctenopharyngodon idella Polyclonal STAT3 Primary Antibody für WB - ABIN6711578
Qian, Qian, Zhang, Zhu, Yan, Ye, Peng, Li, Xu, Sun, Xu: 5-Azacytidine induces cardiac differentiation of human umbilical cord-derived mesenchymal stem cells by activating extracellular regulated kinase. in Stem cells and development 2012
Show all 5 Pubmed References
STAT3 plays an important regulatory role in the inflammatory response during sepsis, and obesity contributes to the dysregulated response observed when STAT3 is inhibited.
HDAC3 silencing impaired the ac-STAT3-to-p-STAT3 transition in the cytoplasm, leading to the subsequent breakdown of STAT3 signaling.
Monocytes are activated by the vascular endothelium during hypertension, in part due to a loss of NO signalling and increased release of IL-6 and hydrogen peroxide by the dysfunctional endothelium and a parallel increase in STAT3 activation in adjacent monocytes.
Inhibition or knockdown of beta-catenin can fully rescue adipogenesis and UCP1 expression in the STAT3-/- adipocytes.
TWEAK/Fn14 mediates atrial-derived cardiomyocytes hypertrophy via JAK2/STAT3 signaling pathway.
Hsf1 is critically involved in the ischemia-induced cardiac hypertrophy via JAK2/STAT3 pathway.
The key function of the hypoxia-associated transcription factor HIF-1alpha together with p-STAT3 in driving CD11b transcription in B cells and controlling B cell's protective activity in experimental inflammatory bowel disease (IBD).
miR-210 promoted neovascularization and neural progenitor cell migration via the SOCS1-STAT3-VEGF-C pathway in middle cerebral artery stroke model.
Innovative CARS (Coherent Anti-Stokes Raman Scattering) microscopy revealed that chemical inhibition of STAT3 activity decreased lipid accumulation and deregulated STAT3-responsive microRNAs, including miR-21.
The IL-6/JAK2/STAT3 signaling pathway plays a critical role in orchestrating the pathogenesis of PCM.
In serum of human IL-1c transgenic mice, IL-6 and IL-17 levels significantly increased, and signal transducer and activator of transcription 3 (Stat3) was activated in joints.
Model suggests a negative role for STAT3 in regulating class switching of the GC B cells from the IgG1 to the IgE producing state.
the involvement of Socs3 in Runx1-Tgfb3 signaling might explain, at least in part, the anteriorly specific downregulation of Tgfb3 expression and Stat3 activity in Runx1 mutants. This is the first study to show that the novel Runx1-Stat3-Tgfb3 axis is essential in anterior palatogenesis.
findings identify TRPC1 as a modulator of HDM-induced airway remodeling via STAT3-mediated increase in mucus production, which provide new insight in our understanding of the molecular basis of airway remodeling
betaIV-Spectrin regulates STAT3 targeting to tune cardiac response to pressure overload.
The expression of CRIF1 in mice with arthritis significantly reduced the number of signal transducer and activator of transcription 3-mediated Th17 cells in the spleen as well as osteoclast differentiation from bone marrow cells.
A moderate high temperature condition at 39 degrees C induces a high lactation capacity of MECs through control of STAT5 and STAT3 signaling.
STAT3-enhancing germline receptor variants contribute to immune evasion through their pleiotropic functions in immune cells.
Study in mouse psoriasis model suggests that Stat3 activation in keratinocytes may impact on Langerhans cell activation in situ via IL-1alpha stimulation, at least in part, and that their presence may be essential for the pathogenesis of psoriasis through producing IL-23.
The RNF20-mediated H2Bub1 cooperating with MOF-mediated H4K16ac activates the transcription of Stat3
There were higher intensities of pSTAT3/beta-actin and STAT3/beta-actin in systemic lupus erythematosus (SLE), and a positive correlation between IL-17 expression and pSTAT3/beta-actin or STAT3/beta-actin intensity.
activation of the transcription factor NFkappaB, involving the small GTPase Rac1, is required for IL-6 production and subsequent STAT3 activation.
the findings of the present study suggested that MSI1 silencing can suppress oral squamous cell carcinoma cell proliferation and progression, in part by inhibiting the activation of the cMyc/STAT3 pathway.
IL6induced activation of STAT3 target genes (e.g. MCL1 and BCL2) was attenuated by triptolide and homoharringtonine.
Our study revealed that Licochalcone (LC)C directly interacts with JAK2 and its downstream signaling kinases, STAT3 to inhibit the catalytic activities of these kinases, thereby not only suppressing proliferation, but also inducing apoptosis in oral squamous cell carcinoma cells.
a positive feedback loop between miR-181b and STAT3 that regulated the Warburg effect in colon cancer was also demonstrated. This study suggested miR-181b/PIAS3/STAT3 axis as a novel target for colon cancer treatment.
HoxA10 interacts with p38 MAPK to repress the activation of p38 MAPK and STAT3 and recruits and facilitates SHP-1 to catalyze the dephosphorylation of p38 MAPK and STAT3.
HDAC3 is an important regulator of STAT3-dependent cell proliferation in liver regeneration and cancer.
findings provide insight into the important role of SIRT2 in colon tumour angiogenesis and suggest that SIRT2/STAT3/VEGFA might be a novel prognostic biomarker and a potential therapeutic target for patients with colorectal cancer.
Through inhibition of the Stat3 signaling pathway.
results reveal a further level of complexity in the relationship between Cav1 and Stat3-ptyr705 than previously thought; in addition, we demonstrate that in a feedback loop, Stat3 inhibition upregulates Cav1 in HeLa cells but not in other lines tested
STAT3 over-expression is associated with cisplatin resistance in cervical cancer; decreasing STAT3 can significantly promote the apoptosis of cervical cancer cells
ANRIL is involved in hepatocellular carcinoma progression by direct targeting of miR-384 and STAT3.
This study shows that cancer-bone microenvironment interactions lead to calcium-STAT3 signaling, which may present an area for therapeutic targeting of metastatic Prostate cancer.
Study showed TESC as a novel regulator of c-Src/IGF1R-mediated STAT3 activation pathway, which enhances ALDH1 expression, consequently reinforces the cancer stem cell-like and radio-resistant properties.
our results concluded that CASC9 promotes STAT3 expression via sponging miR-519d, in return, STAT3 activate CASC9 transcription, forming a positive feedback loop of CASC9/miR-519d/STAT3. The novel finding provides a potential therapeutic target for glioma.
STAT3 phosphorylation, while responsive to exogenous ligands on both soft and stiff matrices, is innately active on a stiff matrix in a ligand/receptor-independent, but ROCK- and JAK2-dependent fashion.
High expression of STAT3 is associated with growth and invasion of ovarian cancer.
Therefore, ANXA2 overexpression play a pivotal role in colorectal cancer invasiveness through Src/ANXA2/STAT3 pathway activation.
Together these studies represent the first investigation of STAT3 signaling that directly influence miR-21 expression in bovine oocytes and cumulus cells.
variations in the STAT3 gene promoter regions, most notably haplotype H3H3, may benefit marker-assisted breeding of Qinchuan cattle.
Thus, activation of STAT3 and inactivation of AKT signaling are involved in structural regression of the corpus luteum.
STA3 facilitates TLR4-dependent IL-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.
STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.
Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate
results show for the first time that interleukin-6 (IL), in the presence of its soluble receptor (sIL-6R), induces activation of JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes
role of shear flow in attenuating activation in endothelial cells
peroxynitrite causes increased expression of VEGF in vascular endothelial cells by a process that requires the activation of STAT3
Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase-mediated activation of STAT3.
STAT3tyr705 phosphorylation/total STAT3 protein at early reperfusion significantly increased by ischemic preconditioning
In porcine circovirus type 2 subclinical infection, SOCS3 interacted with STAT3 and TNF receptor-associated factor 2, suggesting mechanisms by which SOCS3 inhibits IL-6 and TNF-alpha signaling.
this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 and PSEN1 genes via a STAT3-dependent pathway
Studied effect of recombinant porcine leukemia inhibitory factor on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF-supplemented media.
Data suggest that IL-6 (interleukin 6) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).
the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.
Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.
STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways
Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.
Osteoarthritis-cartilage injuries are caused by activating JAK2/STAT3 pathway.
This is the first report of the genetic polymorphisms of the JAK1 and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.
Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.
Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.
Stat3 is required for hepatocyte cell differentiation and liver regeneration.
Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a expression during oogenesis. Accordingly, restoring Cdc25a expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.
PTPN9 plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 and ZBP-89.
Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.
This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.
The results of this study suggested that the stat3/socs3 pathway is a key response in all tissue regeneration in zebrafish.
stat3, a known oncogene and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.
Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP in neighboring cells during zebrafish gastrulation.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 3 (acute-phase response factor)
, signal transducer and activator of transcription 3
, signal transduction and activation of transcription 3
, Signal transducer and activator of transcription 3
, signal transducer and activator of transcription 3-like
, acute phase response factor
, acute-phase response factor
, DNA-binding protein APRF
, Protein Stat3
, signal transducer and activator of transcription 3.1
, stat 3