PTPN6 Proteine (PTPN6)

Protein-tyrosine Phosphatase 1C Proteine (PTPN6)
Auf finden Sie aktuell 20 Protein-tyrosine Phosphatase 1C (PTPN6) Proteine von 12 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PTPN6 Antikörper (206) und PTPN6 Kits (15) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 249 PTPN6 Produkte verfügbar.
DRPLA, hcp, Hcph, HPTP1C, me, motheaten, PTP-1C, Ptp1C, Ptph6, SH-PTP1, SHP, Shp-1, SHP-1L, SHP1
alle Proteine anzeigen Gen GeneID UniProt
PTPN6 23957 Q62227
PTPN6 5777 P29350
PTPN6 116689 P81718

Weitere Synonyme anzeigen

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Am meisten referenzierte PTPN6 Proteine

  1. Human PTPN6 Protein expressed in Escherichia coli (E. coli) - ABIN666674 : Shen, Bastien, Posner, Chrétien: A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases. in Nature 1991 (PubMed)
    Zeige alle 2 Referenzen für 666674

Weitere Proteine zu PTPN6 Interaktionspartnern

Mouse (Murine) Protein-tyrosine Phosphatase 1C (PTPN6) Interaktionspartner

  1. These findings suggest that protein tyrosine phosphatase SHP-1 may act as a positive regulator of osteoblast differentiation through direct association with and dephosphorylation of GSK3beta.

  2. data establish SHP-1 as a critical player in setting the threshold downstream of TCR signaling and identify a novel function of SHP-1 as a regulator of T cell susceptibility to Treg-mediated suppression in vitro and in vivo

  3. human microbiota was able to reduce the levels of tauro-beta-muricholic acid and induce expression of FXR (zeige NR1H4 Proteine) target genes Fgf15 and Shp (zeige LAMC1 Proteine) in ileum after long-term colonization. We show that a human microbiota can change BA composition and induce FXR (zeige NR1H4 Proteine) signaling in colonized mice, but the levels of secondary BAs produced are lower than in mice colonized with a mouse microbiota

  4. SHP (zeige LAMC1 Proteine) and REV-ERBalpha (zeige NR1D1 Proteine) play a critical role in controlling rhythmic CHOP (zeige DDIT3 Proteine) expression in alcoholic fatty liver

  5. Results are consistent with predicted/observed reduction in the Lyn-SHIP-1-PTEN-SHP-1 axis function in B cells from systemic lupus

  6. our results suggest that SHP (zeige LAMC1 Proteine) upregulation upon high-fat feeding leads to lipid accumulation, insulin (zeige INS Proteine) resistance and inflammation in cardiomyocytes.

  7. Our data show that SHP1 is required for the survival of mature thymocytes and the generation of the functional T-cell repertoire, as its absence leads to a reduction in the numbers of CD4 (zeige CD4 Proteine)(+) and CD8 (zeige CD8A Proteine)(+) naive T cells in the peripheral lymphoid compartments.

  8. Our study suggests that metformin exerts its insulin sensitizing effects via inhibition of SHP-1 activity and expression.

  9. we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1.

  10. Mortality of SHP (zeige LAMC1 Proteine)-/- mice after ethanol binge feeding was significantly reduced and Aldh2 (zeige ALDH2 Proteine) mRNA level was higher. After an intoxicating dose of ethanol, SHP (zeige LAMC1 Proteine)-/- mice exhibited faster blood ethanol clearance.

Human Protein-tyrosine Phosphatase 1C (PTPN6) Interaktionspartner

  1. SHP1 DNA methylation (zeige HELLS Proteine) in in patients with B cell non-Hodgkin lymphoma

  2. these results indicate that DNMT1 mediates aberrant methylation and silencing of SHP-1 gene in chronic myelogenous leukemia cells

  3. Results provide evidence that repression of SHP-1, SHP-2 (zeige PTPN11 Proteine) and SOCS-1 (zeige SOCS1 Proteine) gene expression in patient plasma cells supports the constitutive activation of the JAK (zeige JAK3 Proteine)/STAT3 (zeige STAT3 Proteine) pathway and probably leads to higher degrees of bone marrow invasion.

  4. we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1.

  5. Hyperglycemia induces SHP-1 promoter epigenetic modifications, causing its persistent expression and activity and leading to insulin (zeige INS Proteine) resistance, podocyte dysfunction, and DN.

  6. Low SHP1 expression is associated with primary central nervous system lymphoma.

  7. study evaluated SHP1-P2 methylation levels in the lymph nodes of colorectal cancer (CRC) patients; hypothesized that SHP1-P2 methylation levels would be higher in metastatic lymph nodes

  8. Overexpression of SHP1 downregulates the JAK2 (zeige JAK2 Proteine)/STAT3 (zeige STAT3 Proteine) pathway to modulate various target genes and inhibit cell proliferation, migration, and invasion in gastric cancer cells.

  9. This study also found no correlation of SHP-1 expression at diagnosis with response to treatment, although a trend for lower SHP-1 expression was noted in the very small non-responders' group of the 3-month therapeutic milestone.

  10. SYK (zeige SYK Proteine), LYN (zeige LYN Proteine) and PTPN6 were markedly elevated in atherosclerotic plaques of carotid atherosclerosis patients.

PTPN6 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

Alternative names and synonyms associated with PTPN6

  • protein tyrosine phosphatase, non-receptor type 6 (PTPN6)
  • nuclear receptor subfamily 0, group B, member 2 (Nr0b2)
  • protein tyrosine phosphatase, non-receptor type 6 (Ptpn6)
  • DRPLA Protein
  • hcp Protein
  • Hcph Protein
  • HPTP1C Protein
  • me Protein
  • motheaten Protein
  • PTP-1C Protein
  • Ptp1C Protein
  • Ptph6 Protein
  • SH-PTP1 Protein
  • SHP Protein
  • Shp-1 Protein
  • SHP-1L Protein
  • SHP1 Protein

Bezeichner auf Proteinebene für PTPN6

nuclear receptor subfamily 0 group B member 2 , orphan nuclear receptor SHP , small heterodimer partner , hematopoietic cell phosphatase , hematopoietic cell protein-tyrosine phosphatase , protein-tyrosine phosphatase 1C , protein-tyrosine phosphatase SHP-1 , tyrosine-protein phosphatase non-receptor type 6 , 70Z-SHP , PTP-1C , PTPTY-42 , SH-PTP1 , hemopoietic cell phosphatase , SH2 phosphatase 1 , dentatorubro-pallidoluysian atrophy protein , non-receptor type protein tyrosine phosphatase SHP1

100052882 Equus caballus
23957 Mus musculus
5777 Homo sapiens
15170 Mus musculus
116689 Rattus norvegicus
486717 Canis lupus familiaris
100171389 Sus scrofa
100723417 Cavia porcellus
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