anti-PIAS3 (PIAS3) Antikörper

Rhesus Monkey Protein Inhibitor of Activated STAT, 3 (PIAS3) Interaktionspartner

1. Suppressed Th17 levels correlated with upregulated expression of negative regulatory genes, PIAS3, SHP2, and SOCS3 in CD4 T cells during acute SIV infection.

Mouse (Murine) Protein Inhibitor of Activated STAT, 3 (PIAS3) Interaktionspartner

1. Results show that PIAS3 levels are reduced in a mouse model of atherosclerotic lesions and that its expression decreases in conjunction with increases in interleukin-6 (zeige IL6 Antikörper) expression and disease severity. These findings provide evidence that results indicate that PIAS3 is a critical repressor of atherosclerosis progression.

2. Data indicate that PIAS3 (protein inhibitor of activated STAT3) interaction modulates EKLF (erythroid Kruppel-like factor (zeige KLF1 Antikörper)) activity in a promoter-dependent and SUMO-independent manner.

3. PIAS3 suppresses acute graft-versus-host disease by modulating effector T and B cell subsets through inhibition of STAT3 (zeige STAT3 Antikörper) activation.

4. These data indicate that tachypacing decreased ATBF1 (zeige ZFHX3 Antikörper), leading to enhanced STAT3 (zeige STAT3 Antikörper) DNA-binding activity due to the reduced formation of a binary complex of ATBF1 (zeige ZFHX3 Antikörper) and PIAS3.

5. MRL/lpr (zeige FAS Antikörper) mice have significantly increased expressions of STAT3 (zeige STAT3 Antikörper) mRNA and protein and decreased expression of mRNA PIAS3 in the kidneys compared with BALB/C mice.

6. L97A, R99N and R99Q mutations of the PINIT domain (PIAS3(85-272) ) were found to abrogate binding to STAT3 (zeige STAT3 Antikörper), suggesting that these residues were part of a potential binding surface.

7. Our results indicate that Pias3-dependent SUMOylation of photoreceptor-specific transcription factors is a common mechanism that controls both rod and cone photoreceptor subtype specification, regulating distinct molecular targets in the two cell types

8. there is an interaction between Zimp7 (zeige ZMIZ2 Antikörper) and PIAS (zeige PIAS1 Antikörper) proteins with higher preference for PIAS3, in androgen receptor (zeige AR Antikörper)-mediated transcription

9. results indicate a potential role of PIAS3 as transcriptional modulator of TIF2 (zeige NCOA2 Antikörper)-mediated signalling

10. role in inducing SUMO-1 (zeige SUMO1 Antikörper) modification and transcriptional repression of IRF-1 (zeige IRF1 Antikörper)

Human Protein Inhibitor of Activated STAT, 3 (PIAS3) Interaktionspartner

1. PAI-1 (zeige SERPINE1 Antikörper) interacted with PIAS3 to regulate Stat3 (zeige STAT3 Antikörper)-dependent gene expression and miR (zeige MLXIP Antikörper)-34a was transcriptionally suppressed by Stat3 (zeige STAT3 Antikörper) to form a positive regulatory loop through Stat3 (zeige STAT3 Antikörper) signaling in non-small cell lung cancer cells.

2. Levels of PIAS3 are significantly lower, in contrast with phosphorylation of STAT3 (zeige STAT3 Antikörper), in women with endometriosis compared to women without endometriosis.

3. TRIM8 (zeige TRIM8 Antikörper) activates STAT3 (zeige STAT3 Antikörper) by suppressing the expression of PIAS3, an inhibitor of STAT3 (zeige STAT3 Antikörper), most likely through E3-mediated ubiquitination and proteasomal degradation.

4. Low PIAS3 expression is associated with breast cancer organoid invasiveness.

5. SHP2 (zeige PTPN11 Antikörper), SOCS3 (zeige SOCS3 Antikörper) and PIAS3 levels are reduced in medulloblastomas in vivo and in vitro, of which PIAS3 downregulation is more reversely correlated with STAT3 (zeige STAT3 Antikörper) activation. In resveratrol-suppressed medulloblastoma cells with STAT3 (zeige STAT3 Antikörper) downregulation and decreased incidence of STAT3 (zeige STAT3 Antikörper) nuclear translocation, PIAS3 is upregulated, the SHP2 (zeige PTPN11 Antikörper) level remains unchanged and SOCS3 (zeige SOCS3 Antikörper) is downregulated.

6. The results revealed that although the expression levels of SOCS1 (zeige SOCS1 Antikörper), SOCS3 (zeige SOCS3 Antikörper) and, in particular, pSHP2, tend to decrease in the four types of astrocytomas, PIAS3 downregulation is more negatively correlated with STAT3 (zeige STAT3 Antikörper) activation in the stepwise progress of astrocytomas and would indicate an unfavorable outcome.

7. 3-Formylchromone inhibits proliferation and induces apoptosis of multiple myeloma cells by abrogating STAT3 (zeige STAT3 Antikörper) signaling through the induction of PIAS3.

8. PIAS3 may serve as a biomarker for predicting hormone therapy stratification, although it is limited to those breast cancer patients receiving hormone therapy.

9. Taken together, these results suggest that PIAS3 functions as a positive regulator of HIF-1alpha (zeige HIF1A Antikörper)-mediated transcription by increasing its protein stability.

10. PIAS3 suppression may be protective against joint destruction in rheumatoid arthritis by regulating synoviocyte migration, invasion, and activation.