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Human IL12B Protein expressed in Escherichia coli (E. coli) - ABIN1305061
DAndrea, Aste-Amezaga, Valiante, Ma, Kubin, Trinchieri: Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. in The Journal of experimental medicine 1993
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Mouse (Murine) IL12B Protein expressed in Escherichia coli (E. coli) - ABIN1305060
DAndrea, Rengaraju, Valiante, Chehimi, Kubin, Aste, Chan, Kobayashi, Young, Nickbarg: Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. in The Journal of experimental medicine 1992
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Human IL12B Protein expressed in Human Cells - ABIN2648866
Wang, Li, Ge, Li, Wang, Gao, Qiu, Liu: Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system. in Nature immunology 2015
The anti-EGFR (zeige EGFR Proteine) viroplexes with IL-12 (zeige IL12A Proteine) and salmosin genes exhibited the most effective therapeutic efficacy in a mouse tumor model, especially when combined with doxorubicin.
baseline serum IL-12 levels were significantly higher in those pediatric hematopoietic stem cell transplantation recipients who did not develop acute graft versus host disease
Human neutrophil elastase (zeige ELANE Proteine) is involved in transactivation of TLR4 (zeige TLR4 Proteine) through activation of DUOX-2 (zeige DUOX2 Proteine)/EGFR (zeige EGFR Proteine) and synergistically enhances IL-12p40 production by macrophages stimulated with LPS (zeige IRF6 Proteine).
our results suggested a significant association between IL-12B 3'-UTR and rs6887695 SNPs and ADs (zeige AGPS Proteine).
All the tested TLRAs induced greater infant IFN-alpha2 (zeige IFNA2 Proteine) production compared to newborn and adult blood. In contrast, CpG induced greater IFN-gamma (zeige IFNG Proteine), IL-1beta (zeige IL1B Proteine), IL-4 (zeige IL4 Proteine), IL-12p40, IL-10 (zeige IL10 Proteine) and CXCL8 (zeige IL8 Proteine) in newborn than in infant and adult blood.
Simultaneous elevated circulating levels of IL-18 (zeige IL18 Proteine) and IL-12 (zeige IL12A Proteine) increased the event rate after 2 years in Coronary Artery Disease patients, independent of hyperglycemia
Single-nucleotide-polymorphisms of IL12B may be considered a high-risk factor for Takayasu arteritis in Chinese Han population
IL-12B -1188 C allele may be a protective factor against asthma in East Asians
The low expression of HDAC3 (zeige HDAC3 Proteine) and overexpession of inflammatory cytokines (IL-18 (zeige IL18 Proteine), IL-12 (zeige IL12A Proteine) and TNF-alpha (zeige TNF Proteine)) in intrahepatic cholestasis of pregnancy may be involved in liver cell apoptosis and in the pathophysiology of the disease.
Polymorphisms of IFNG (zeige IFNG Proteine), IL12B and IL12RB1 (zeige IL12RB1 Proteine) genes in paracoccidioidomycosis Brazilian patients do not affect the susceptibility or resistance to the disease.
Data indicate that there was a differential transcription of 381 genes which changed greater than two fold in B1a of p40-/-IL-2Ralpha-/- mice.
this study shows that a systemic IL-12 (zeige IL12A Proteine) primes intestinal cells that became more prone to develop inflammatory responses, which is long-lasting because intestinal cells maintain their inflammatory potential and their ability to aggravate colitis
this study shows that endosomal signalling by Lactobacillus acidophilus that leads to IL-12 (zeige IL12A Proteine) production is inhibited by TLR stimulation from the plasma membrane
Irradiation-induced IL-6 (zeige IL6 Proteine) can decrease IL-12 (zeige IL12A Proteine) production through the inhibition of C-Rel (zeige NFkBP65 Proteine) phosphorylation by the IL-6 (zeige IL6 Proteine)/STAT3 (zeige STAT3 Proteine) signaling pathway.
The IL-12 (zeige IL12A Proteine) response by dendritic cells against S. aureus is highly growth phase dependent.
the PI3K pathway mediated IL-12 (zeige IL12A Proteine) inhibition but did not interfere with the inhibition of IL-23 (zeige IL23A Proteine) or stimulation of IL-10 (zeige IL10 Proteine).
Data indicate that sera from treated with cholesterol-p40 (Il12b)-siRNA contained significantly reduced concentrations of p40.
this study demonstrates viral RNA analog-induced transcription synergy of Il6 (zeige IL6 Proteine) and Il12b via IFN regulatory factor (IRF)1 (zeige IRF1 Proteine) (TLR3 (zeige TLR3 Proteine)-TIR domain-containing adaptor inducing IFN-beta (zeige TICAM1 Proteine) [TRIF (zeige RNF138 Proteine)] responsive), C/EBPbeta (zeige CEBPB Proteine) (TLR7 (zeige TLR7 Proteine)-MyD88 (zeige MYD88 Proteine) responsive), and JunB (zeige JUNB Proteine) (all responsive).
These findings reveal a critical role for IL-12 (zeige IL12A Proteine) in shaping the anti-inflammatory biofilm milieu by promoting MDSC recruitment.
our results suggest that IL-12p40 acts as a negative regulator of autoimmune cholangitis in IL-2Ralpha-/- mice. Compared to IL-2Ralpha-/- mice, p40-/-IL-2Ralpha-/- mice develop liver fibrosis and reduced colitis.
Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (zeige TNF Proteine), IL-6 (zeige IL6 Proteine), IL-12p40, IL-1beta (zeige IL1B Proteine), and resulted in increased expression of the apoptosis initiator caspase-8 (zeige CASP8 Proteine) and bcl2L1 (zeige BCL2L1 Proteine).
The results showed that the expression of TNF-alpha (zeige TNF Proteine), iNOS (zeige NOS2 Proteine), and IL-6 (zeige IL6 Proteine) in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (zeige IL12A Proteine) was unaffected.[IL-6 (zeige IL6 Proteine), IL-12 (zeige IL12A Proteine)]
study investigated hypothesis that CD40 (zeige CD40 Proteine) signalling is impaired in Mycobacterium avium subspecies paratuberculosis(MAP)-infected macrophages; propose that MAP interferes with gene expression of iNOS (zeige NOS2 Proteine) and IL-12p40 genes downstream of p38 (zeige MAPK14 Proteine)
In rhesus macaques plasmacytoid dendritic cells in peripheral blood express IL-12p40 upon TLR-7 (zeige TLR7 Proteine)/8 and TLR-9 (zeige TLR9 Proteine) stimulation, which could potentially affect their response to vaccination and viral infection.
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
, IL-12 subunit p40
, IL12, subunit p40
, NK cell stimulatory factor chain 2
, cytotoxic lymphocyte maturation factor 40 kDa subunit
, interleukin 12, p40
, interleukin-12 beta chain
, interleukin-12 subunit beta
, natural killer cell stimulatory factor, 40 kD subunit
, CLMF p35
, IL-12 subunit p35
, cytotoxic lymphocyte maturation factor 35 kDa subunit
, interleukin 12
, interleukin-12 subunit alpha
, IL-12 p40
, IL-23 subunit p40
, interleukin-12 p40
, interleukin-12 p40 subunit
, interleukin 12B
, interleukin-12 p35 subunit
, IL-12 p40 subunit
, interleukin 12 p40.b
, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
, interleukin 12Ba (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
, interleukin 12 p40 subunit
, interleukin-12 p40 chain
, interleukin 12 40kDa subunit
, Cytotoxic lymphocyte maturation factor 40 kDa subunit
, Interleukin-12 subunit beta