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Human IL12B Protein expressed in Escherichia coli (E. coli) - ABIN1305061
DAndrea, Aste-Amezaga, Valiante, Ma, Kubin, Trinchieri: Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. in The Journal of experimental medicine 1993
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Mouse (Murine) IL12B Protein expressed in Escherichia coli (E. coli) - ABIN1305060
DAndrea, Rengaraju, Valiante, Chehimi, Kubin, Aste, Chan, Kobayashi, Young, Nickbarg: Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. in The Journal of experimental medicine 1992
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Human IL12B Protein expressed in Human Cells - ABIN2648866
Wang, Li, Ge, Li, Wang, Gao, Qiu, Liu: Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system. in Nature immunology 2015
The demonstrated allelic expression imbalance supports the idea that the IL12B risk haplotype confers susceptibility not only to Crohn's disease onset but to also relapse through increased IL12B mRNA expression.
the present study IL-12B gene status was evaluated in 50 new sputum smear-positive pulmonary tuberculosis patients.
The rs17860508 polymorphism in the IL12B promoter region may influence the risk of developing ovarian endometriosis by altering the endometrial expression of IL12B of in Northern Chinese women.
In the study, 250 ONFH patients and 228 matched healthy controls from Shandong Province were recruited to evaluate the influence of interleukin-10 (IL-10 (zeige IL10 Proteine)) rs1800872, IL-12 (zeige IL12A Proteine) rs3212227 and tumor necrosis factor-(TNF-alpha (zeige TNF Proteine)) rs1800629 polymorphism in osteonecrosis of the femoral head (ONFH). IL-12 (zeige IL12A Proteine) rs3212227 AC genotype confer genetically susceptibility to ONFH in the Chinese Han population.
The rs6871626 single nucleotide polymorphism in IL-12B is associated with the pathophysiology of Takayasu arteritis.
INSR (zeige INSR Proteine) rs1051690 SNP is associated with increased risk of gastric cancer, while polymorphisms in IL12B, CCND1 (zeige CCND1 Proteine) and IL10 (zeige IL10 Proteine) genes are not linked with the presence of gastric cancer
The anti-EGFR (zeige EGFR Proteine) viroplexes with IL-12 (zeige IL12A Proteine) and salmosin genes exhibited the most effective therapeutic efficacy in a mouse tumor model, especially when combined with doxorubicin.
baseline serum IL-12 levels were significantly higher in those pediatric hematopoietic stem cell transplantation recipients who did not develop acute graft versus host disease
Human neutrophil elastase (zeige ELANE Proteine) is involved in transactivation of TLR4 (zeige TLR4 Proteine) through activation of DUOX-2 (zeige DUOX2 Proteine)/EGFR (zeige EGFR Proteine) and synergistically enhances IL-12p40 production by macrophages stimulated with LPS (zeige IRF6 Proteine).
our results suggested a significant association between IL-12B 3'-UTR and rs6887695 SNPs and ADs (zeige AGPS Proteine).
Results show the overproduction of IL-12 (zeige IL12A Proteine)/23p40 in dendritic cells, leading to Th1 (zeige HAND1 Proteine) and Th17 programs in a mouse model of Yersinia enterocolitica-induced reactive arthritis.
this study demonstrates that regulation of IL-12p40 by hypoxia-inducible factor-1alpha controls Th1 (zeige HAND1 Proteine)/Th17 responses to prevent mucosal inflammation
the nuclear localized CA-VI (zeige CA6 Proteine) B selectively promotes IL-12 (zeige IL12A Proteine) expression by interaction with protein arginine N-methyltransferase 5 (PRMT5 (zeige PRMT5 Proteine)), which reduces symmetric dimethylation of histone H3 (zeige HIST3H3 Proteine) arginine 8 modification (H3R8me2s) at Il12 (zeige IL12A Proteine) promoters to facilitate chromatin accessibility, selectively enhancing c-Rel (zeige NFkBP65 Proteine) binding to the Il12b promoter.
The authors found that the expressions of the mRNAs of both IL-12p35 and IL-12p40 were significantly reduced in the oxygen-induced retinopathy retinas compared to that of the room air-raised control. The results suggest that IL-12 (zeige IL12A Proteine) plays important roles in inhibiting pathological retinal neovascularization.
Data indicate that there was a differential transcription of 381 genes which changed greater than two fold in B1a of p40-/-IL-2Ralpha-/- mice.
this study shows that a systemic IL-12 (zeige IL12A Proteine) primes intestinal cells that became more prone to develop inflammatory responses, which is long-lasting because intestinal cells maintain their inflammatory potential and their ability to aggravate colitis
this study shows that endosomal signalling by Lactobacillus acidophilus that leads to IL-12 (zeige IL12A Proteine) production is inhibited by TLR stimulation from the plasma membrane
Irradiation-induced IL-6 (zeige IL6 Proteine) can decrease IL-12 (zeige IL12A Proteine) production through the inhibition of C-Rel (zeige NFkBP65 Proteine) phosphorylation by the IL-6 (zeige IL6 Proteine)/STAT3 (zeige STAT3 Proteine) signaling pathway.
The IL-12 (zeige IL12A Proteine) response by dendritic cells against S. aureus is highly growth phase dependent.
the PI3K pathway mediated IL-12 (zeige IL12A Proteine) inhibition but did not interfere with the inhibition of IL-23 (zeige IL23A Proteine) or stimulation of IL-10 (zeige IL10 Proteine).
Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (zeige TNF Proteine), IL-6 (zeige IL6 Proteine), IL-12p40, IL-1beta (zeige IL1B Proteine), and resulted in increased expression of the apoptosis initiator caspase-8 (zeige CASP8 Proteine) and bcl2L1 (zeige BCL2L1 Proteine).
The results showed that the expression of TNF-alpha (zeige TNF Proteine), iNOS (zeige NOS2 Proteine), and IL-6 (zeige IL6 Proteine) in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (zeige IL12A Proteine) was unaffected.[IL-6 (zeige IL6 Proteine), IL-12 (zeige IL12A Proteine)]
study investigated hypothesis that CD40 (zeige CD40 Proteine) signalling is impaired in Mycobacterium avium subspecies paratuberculosis(MAP)-infected macrophages; propose that MAP interferes with gene expression of iNOS (zeige NOS2 Proteine) and IL-12p40 genes downstream of p38 (zeige MAPK14 Proteine)
In rhesus macaques plasmacytoid dendritic cells in peripheral blood express IL-12p40 upon TLR-7 (zeige TLR7 Proteine)/8 and TLR-9 (zeige TLR9 Proteine) stimulation, which could potentially affect their response to vaccination and viral infection.
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
, IL-12 subunit p40
, IL12, subunit p40
, NK cell stimulatory factor chain 2
, cytotoxic lymphocyte maturation factor 40 kDa subunit
, interleukin 12, p40
, interleukin-12 beta chain
, interleukin-12 subunit beta
, natural killer cell stimulatory factor, 40 kD subunit
, IL-12 p40
, IL-23 subunit p40
, interleukin-12 p40
, interleukin-12 p40 subunit
, IL-12 p40 subunit
, interleukin 12 p40.b
, interleukin 12B
, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
, interleukin 12Ba (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
, interleukin 12 p40 subunit
, interleukin-12 p40 chain
, interleukin 12 40kDa subunit
, Cytotoxic lymphocyte maturation factor 40 kDa subunit
, Interleukin-12 subunit beta