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anti-Human IL-6 Receptor Antikörper:
anti-Rat (Rattus) IL-6 Receptor Antikörper:
anti-Mouse (Murine) IL-6 Receptor Antikörper:
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Human Monoclonal IL-6 Receptor Primary Antibody für ELISA - ABIN2688946
Müller-Newen, Köhne, Keul, Hemmann, Müller-Esterl, Wijdenes, Brakenhoff, Hart, Heinrich: Purification and characterization of the soluble interleukin-6 receptor from human plasma and identification of an isoform generated through alternative splicing. in European journal of biochemistry / FEBS 1996
Show all 15 Pubmed References
Human Monoclonal IL-6 Receptor Primary Antibody für CyTOF, ELISA (Capture) - ABIN4899503
Hurst, Wilkinson, McLoughlin, Jones, Horiuchi, Yamamoto, Rose-John, Fuller, Topley, Jones: Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. in Immunity 2001
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Human Monoclonal IL-6 Receptor Primary Antibody für CyTOF, ELISA (Capture) - ABIN4899502
Hurst, McLoughlin, Monslow, Owens, Morgan, Fuller, Topley, Jones: Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. in Journal of immunology (Baltimore, Md. : 1950) 2002
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Human Monoclonal IL-6 Receptor Primary Antibody für FACS, ELISA - ABIN2688945
Hirano, Nakajima, Hibi: Signaling mechanisms through gp130: a model of the cytokine system. in Cytokine & growth factor reviews 1998
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Human Monoclonal IL-6 Receptor Primary Antibody für IHC (fro), FACS - ABIN1383672
Dubois, Massacrier, Vanbervliet, Fayette, Brière, Banchereau, Caux: Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes. in Journal of immunology (Baltimore, Md. : 1950) 1998
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Mouse (Murine) Polyclonal IL-6 Receptor Primary Antibody für CyTOF, ELISA (Capture) - ABIN4899510
Chalaris, Rabe, Paliga, Lange, Laskay, Fielding, Jones, Rose-John, Scheller: Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils. in Blood 2007
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Human Monoclonal IL-6 Receptor Primary Antibody für FACS - ABIN1383676
Lebeau, Montero Julian, Wijdenes, Müller-Newen, Dahmen, Chérel, Heinrich, Brailly, Hallet, Godard, Minvielle, Jacques: Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties. in FEBS letters 1997
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Mouse (Murine) Polyclonal IL-6 Receptor Primary Antibody für ELISA (Detection), FACS - ABIN4899507
Osuchowski, Siddiqui, Copeland, Remick: Sequential ELISA to profile multiple cytokines from small volumes. in Journal of immunological methods 2005
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Mouse (Murine) Monoclonal IL-6 Receptor Primary Antibody für CyTOF, FACS - ABIN4899509
Bailey, Huang, Kam, Farzan: Ifitm3 limits the severity of acute influenza in mice. in PLoS pathogens 2012
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Human Monoclonal IL-6 Receptor Primary Antibody für FACS - ABIN1383675
Mouthon, Freund, Titeux, Katz, Guichard, Breton-Gorius, Vainchenker: Growth and differentiation of the human megakaryoblastic cell line (ELF-153): a model for early stages of megakaryocytopoiesis. in Blood 1994
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The expression of IL-6, IL-6R and gp130 transcripts were detected very early, increased during the first week of life and were predominantly expressed in the head, epidermis and neuromasts of the anterior and posterior lateral line system.
sIL (zeige PMEL Antikörper)-6R may be a useful biomarker to assess insulin (zeige INS Antikörper) resistance among morbidly obese subjects
Study identified variants associated with the age of onset of Alzheimer's disease in APOE (zeige APOE Antikörper) varepsilon4 carriers. Across five datasets, p.D358A had a meta P = 3 x10-4 and an odds ratio = 1.3, 95% confidence interval 1.12 -1.48. Study suggests that a common coding region variant of the IL-6 (zeige IL6 Antikörper) receptor results in neuroinflammatory changes that may influence the age of onset of Alzheimer's disease in APOE (zeige APOE Antikörper) varepsilon4 carriers.
IL-6R protein expression on plasma membrane of ovarian cancer cells mediates enhanced cell migration/invasiveness in response to IL6 (zeige IL6 Antikörper) in ascites.
IL6R protein levels were higher in bone than in lymph node and visceral metastases of castration-resistant prostate cancer.
study focused on IL-6 (zeige IL6 Antikörper) and activation of its receptors gp80 (zeige CLU Antikörper) and gp130 (zeige IL6ST Antikörper) in human gingival fibroblasts in order to assess the effects of the commercial acid resins Jet (zeige FBXL15 Antikörper) Kit, Unifast, and Duralay on control of inflammation
In the present study, the authors show that deletion of a triple serine (3S) motif (Ser (zeige SIGLEC1 Antikörper)-359 to Ser (zeige SIGLEC1 Antikörper)-361) adjacent to the cleavage site is sufficient to prevent IL-6R cleavage by ADAM17 (zeige ADAM17 Antikörper), but not ADAM10 (zeige ADAM10 Antikörper). We find that the impaired shedding is caused by the reduced distance between the cleavage site and the plasma membrane.
IL6R SNPs are associated with simultaneously high CRP (zeige CRP Antikörper), LDL and ApoB (zeige APOB Antikörper) levels.
The sgp130, IL-6 (zeige IL6 Antikörper), and sIL (zeige PMEL Antikörper)-6R concentrations were statistically significantly elevated in patients with diabetic retinopathy (DR), suggesting a probable contributing role of the IL-6 (zeige IL6 Antikörper) trans-signaling pathway to the pathophysiology of DR.
The mRNA expression of IL6R was inversely correlated with miR (zeige MLXIP Antikörper)-449a in osteosarcoma tissues. In addition, JAK1 (zeige JAK1 Antikörper)/STAT3 (zeige STAT3 Antikörper) signaling pathway was regulated by circ_0009910/miR (zeige MLXIP Antikörper)-449a/IL6R axis.
IL-6 receptor blockade has an effect on high-sensitivity troponin T and NT-proBNP in rheumatoid arthritis
IL-6sR and gp130 (zeige ANPEP Antikörper), but not IL-6R alpha, play important roles in regulation of granulosa cell survival
Mechanical injury potentiates the catabolic effects of TNFalpha (zeige TNF Antikörper) and IL-6 (zeige IL6 Antikörper)/sIL (zeige STIL Antikörper)-6R in causing proteoglycan (zeige Vcan Antikörper) degradation in human and bovine cartilage.
role for IL-6R expression in regulating RBC (zeige CACNA1C Antikörper) alloimmunization
There are functional interleukin-6 receptor-alpha on tanycytes at the bottom of the third ventricle, in agreement with the possibility that ventricular administration of IL-6 (zeige IL6 Antikörper) decreases obesity in mice via an effect on this cell type.
we present evidence for the role of M2 phenotype TAM (zeige CCNA1 Antikörper) in IL-6 (zeige IL6 Antikörper) receptor-mediated signals, particularly tyrosine phosphorylation of STAT3 (zeige STAT3 Antikörper), responsible for the prosurvival adaptation of tumor cells to hypoxia.
TNF (zeige TNF Antikörper)/IL-6 (zeige IL6 Antikörper) generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1 (zeige NFATC1 Antikörper), DNAX-activation protein 12 (zeige TYROBP Antikörper), and cell proliferation
C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock.
Interleukin-6 receptor alpha may have a role in skin lesions in a murine model of systemic lupus erythematosus
findings identify TRAF3 (zeige TRAF3 Antikörper) and PTPN22 (zeige PTPN22 Antikörper) as inhibitors of IL-6R signaling in B cells and reveal a previously uncharacterized role for TRAF3 (zeige TRAF3 Antikörper) in the regulation of plasma cell differentiation
Data show that blockade of interleukin-6 receptor by an anti-IL-6R antibody can augment the anti-arthritic effect of glucocorticoids (GCs (zeige UGCG Antikörper)) and inhibit the bone loss they cause.
established that endogenous IL-6R of both human and murine origin is shed by ADAM17 (zeige ADAM17 Antikörper) in an induced manner, whereas constitutive release of endogenous IL-6R is largely mediated by ADAM10 (zeige ADAM10 Antikörper)
Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorgammaT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
interleukin 6 receptor
, interleukin 6 receptor alpha
, interleukin-6 receptor subunit alpha
, CD126 antigen
, IL-6 receptor subunit alpha
, IL-6R 1
, membrane glycoprotein 80
, IL-6R subunit alpha
, interleukin 6 receptor, alpha
, IL-6 receptor alpha chain