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SYK (zeige SYK Proteine) mediates the actions of EPO (zeige EPO Proteine) and GM-CSF (zeige CSF2 Proteine) and coordinates with TGF-beta (zeige TGFB1 Proteine) in erythropoiesis.
Exome sequencing identified candidate variants, including a missense mutation in DUOX2 (zeige DUOX2 Proteine) that impaired its function and a frameshift mutation in CSF2RB that was associated with Crohn's Disease in an independent cohort of Ashkenazi Jewish individuals.
In a genetic analysis of Ashkenazi Jewish individuals, we associated Crohn's Disease with a frameshift mutation in CSF2RB. Intestinal monocytes from carriers of this mutation had reduced responses to granulocyte-macrophage colony-stimulating factor (zeige CSF2 Proteine), providing an additional mechanism for alterations to the innate immune response in individuals with Crohn's Disease.
VitD-mediated stimulation of GC anti-inflammatory affects human monocytes in a process involving GM-CSF and MED14
These data suggest that expression of GM-CSF (zeige CSF2 Proteine) and its receptor subunits by colon tumors may be a useful marker for prognosis
This study reveals a novel functional role of clathrin-coated structure in GMR (zeige CSF2RA Proteine) signaling and the oncogenesis of JAK2V617F.
JAK (zeige JAK3 Proteine) kinase binding to betac requires the presence of three critical betac lysine residues, and this binding event is essential for receptor ubiquitination, endocytosis, and signaling.
Granulocyte/macrophage colony-stimulating factor (zeige CSF2 Proteine) causes a paradoxical increase in the BH3-only (zeige BBC3 Proteine) pro-apoptotic protein Bim (zeige BCL2L11 Proteine) in human neutrophils
The results of the study support CSF2RB as a risk factor common to both schizophrenia and major depression in the Chinese Han population.
Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations [case report]
IL-3 (zeige IL-3 Proteine) signaling does not contribute to Jak2 (zeige JAK2 Proteine) V617F myeloproliferative neoplasm pathogenesis.
blockage of betaCR abrogated the EPO (zeige EPO Proteine)-conferred anti-inflammatory action on oxLDL-induced production of macrophage inflammatory protein-2 (zeige CXCL2 Proteine)
Deletion of the Csf2rb gene slows the progression of chronic myelomonocytic leukemia in mice.
Increased levels of Csf2rb on hematopoietic stem cells lead to expansion of these populations in ApoE (zeige APOE Proteine)(-/-) BM-transplanted Ldlr (zeige LDLR Proteine)(-/-) mice, contributing to monocytosis and increased lesional macrophage content.
Erythropoietin (zeige EPO Proteine) attenuates the impaired systolic contractility associated with sepsis by activation of the beta-common receptor.
Findings indicate that SLP-76 (zeige LCP2 Proteine) is an essential signaling component for basophil activation downstream of both FcepsilonRI (zeige FCER1A Proteine) and the IL-3 (zeige IL-3 Proteine) receptor.
Csf-2 (zeige CSF2 Proteine) receptor acts in the steady state to promote the survival & homeostasis of nonlymphoid tissue-resident CD103 (zeige ITGAE Proteine)(+) & CD11b (zeige ITGAM Proteine)(+) DCs. It is dispensable for the differentiation & innate function of inflammatory DCs during acute injuries.
GM-CSF can regulate beta-catenin stability, most likely via GSK3b.
Suggest that beta common receptor may play an integrative role in the erythropoietin (zeige EPO Proteine) signaling-mediated activation of eNOS (zeige NOS3 Proteine) in endothelial cells.
NF-kappaB (zeige NFKB1 Proteine) activation by beta(c) is dependent on TNFR (zeige TNFRSF1A Proteine)-associated factor (TRAF)6 (zeige TRAF6 Proteine); association of TRAF6 (zeige TRAF6 Proteine) with beta(c) requires a consensus-binding motif found in other molecules known to interact with TRAF6 (zeige TRAF6 Proteine).
The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP).
cytokine receptor common subunit beta
, interleukin 3 common beta chain
, colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macrophage)
, colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
, interleukin 3 receptor beta common
, cytokine receptor common subunit beta-like
, GM-CSF/IL-3/IL-5 receptor common beta subunit
, GM-CSF/IL-3/IL-5 receptor common beta-chain
, colony-stimulating factor-2 receptor, beta, low-affinity
, interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity)
, CD131 antigen
, beta c
, common beta chain
, interleukin-5 receptor beta chain