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ITCH Produkte

(Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))

Kategorien

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].

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Ausgewählte ITCH Kategorien

ITCH Antikörper

High quality antibodies with extensive validation data.

ITCH ELISA Kits

Reliable ELISA kits for a wide range of species.

ITCH Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene ITCH Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation ELISA, WB, IF, FACS
Validierungen
  • (5)
Kat. Nr. ABIN334426
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rabbit, Rat
Applikation WB, IF
Validierungen
  • (1)
  • (4)
Kat. Nr. ABIN968415
Menge 150 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB
Validierungen
  • (3)
Kat. Nr. ABIN7268032
Menge 100 μL
Datenblatt Datenblatt

Empfohlene ITCH ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human, Mouse
Analytical Method Qualitative Cell ELISA
Validierungen
Kat. Nr. ABIN1381250
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6951536
Menge 96 tests
Datenblatt Datenblatt

Empfohlene ITCH Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN7123643
Menge 50 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1308153
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3093147
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren ITCH Produkten

Bozóky, Savchenko, Csermely, Korcsmáros, Dúl, Pontén, Székely, Klein: "Novel signatures of cancer-associated fibroblasts." in: International journal of cancer, Vol. 133, Issue 2, pp. 286-93, (2013) (PubMed).

Di Marcotullio, Ferretti, Greco, De Smaele, Po, Sico, Alimandi, Giannini, Maroder, Screpanti, Gulino: "Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination." in: Nature cell biology, Vol. 8, Issue 12, pp. 1415-23, (2006) (PubMed).

Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: "The DNA sequence and comparative analysis of human chromosome 20. ..." in: Nature, Vol. 414, Issue 6866, pp. 865-71, (2002) (PubMed).

Courbard, Fiore, Adélaïde, Borg, Birnbaum, Ollendorff: "Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH." in: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 45267-75, (2002) (PubMed).

Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).

Perry, Hustad, Swing, OSullivan, Jenkins, Copeland: "The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice." in: Nature genetics, Vol. 18, Issue 2, pp. 143-6, (1998) (PubMed).

Synonyme und alternative Namen zu ITCH

itchy E3 ubiquitin protein ligase (ITCH), itchy, E3 ubiquitin protein ligase (Itch), itchy E3 ubiquitin protein ligase (Itch), 6720481N21Rik, 8030492O04Rik, A130065M08, AIF4, AIP4, C230047C07Rik, dJ468O1.1, NAPP1

Bezeichner auf Proteinebene für ITCH

  • E3 ubiquitin-protein ligase Itchy homolog
  • NFE2-associated polypeptide 1
  • atrophin-1 interacting protein 4
  • dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4))
  • itchy E3 ubiquitin protein ligase homolog
  • E3 ubiquitin-protein ligase Itchy
  • itch E3 ubiquitin ligase
  • itchy homolog E3 ubiquitin protein ligase
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