anti-Prohibitin (PHB) Antikörper

Human Prohibitin (PHB) Interaktionspartner

1. PHB (prohibitin) expression observed to increase in pancreatic ductal adenocarcinoma (PDAC), tissues, and patient sera. Its expression negatively correlates with overall patient survival.

2. findings show that reduced PHB1 expression induces IL-8 transcription by activating NF-kappaB and AP-1, resulting in enhanced IL-8 expression and release to promote tumorigenesis.

3. observations suggest a pivotal role for the PHB-CRAF-MAPK signalling axis in regulating the polarization and pathogenicity of Th17 cells and unveil druggable targets in autoimmune disorders such as MS.

4. prohibitin is an important negotiator protein that regulates dopaminergic cell death in substantia nigra and their protection in ventral tegmental area in Parkinson's Disease.

5. Results show that PHB expression is significantly increased in metastatic prostate cancer and represents a strong marker predicting survival, along with ALDH6A1 and HSP27.

6. Data suggest that prohibitin (PHB) plays a crucial role in integrating cell signaling events with metabolic switches, and may serve as a potential target for cancer immunotherapeutic [Review].

7. prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein

8. Up regulation of PHB in relapsing vs remission MS patients imply the potential use of PHB to clinically evaluate subclinical disease status towards prognosis of an oncoming relapse

9. Study gives attention to the functional role and regulatory mechanism of PHB proteins in cardiovascular health and diseases (VCD) and its associated implications. Various molecular pathways involved in PHB function and its regulation are analyzed. In neoplasm, PHB is shown to act through many mechanisms by acting as oncogene, tumor suppressor, antioxidant, antiapoptotic, in angiogenesis, autophagy etc. [review]

10. This study support the role of miR-195 as anti-proliferative miRNA via targeting of PHB1 in melanoma cells

11. Data (including data from studies using knockout mice) suggest that cell surface-expressed PHB is involved in Enterovirus 71 entry into neuronal cells; mitochondrial membrane-bound PHB associates with virus replication complex and facilitates viral replication.

12. The G to A transition but not the C-to-T transition in the 3'-UTR of prohibitin was associated with an increased risk of gastric cancer in Chinese population.

13. Case Report: imbalance between ROS and antioxidants together with failure of signal transduction in the glomerular slit membrane caused by prohibitin 2 abnormality could have contributed to nephrotic syndrome.

14. This beta-catenin-mediated activation of PHB expression was independent of cMYC activation, a product of Wnt signaling.These data indicate that PHB is a direct target of beta-catenin and the increased level of PHB in leukemia can be regulated by Wnt signaling

15. Study elucidates an important role of PHBP1 in promoting esophageal squamous cell carcinoma partly via increasing PHB expression.

16. decrease of PCMT1 significantly increased the proportion of D-Asp residues in PHB1 and had significant and fatal impacts on morphology and functions of the mitochondria, such as ATP production and the mitochondrial fusion-fission system

17. Endoplasmic reticulum resident chaperone GRP78, mitochondrial protein Prohibitin and heterogeneous nuclear ribonucleoprotein hnRNPC (C1/C2) have been shown to interact with viral RNA. Hence it is proposed that these are the principle candidates governing endoplasmic reticulum stress-induced apoptosis in JEV infection.

18. PHB1 down regulation suppresses liver cancer and bile duct cancer tumorigenesis.

19. PHB has an unexpected nuclear role in human embryonic stem cells that is required for self-renewal and that it acts with HIRA in chromatin organization to link epigenetic organization to a metabolic circuit.

20. results demonstrate that the H19-Igf2 axis is negatively regulated by CTCF-PHB1 cooperation and that H19 is involved in modulating the growth-suppressive effect of PHB1 in the liver.

Mouse (Murine) Prohibitin (PHB) Interaktionspartner

1. observations suggest a pivotal role for the PHB-CRAF-MAPK signalling axis in regulating the polarization and pathogenicity of Th17 cells and unveil druggable targets in autoimmune disorders such as MS.

2. Neuronal expression of the mitochondrial protein prohibitin confers profound neuroprotection in a mouse model of focal cerebral ischemia.

3. prohibitin is an important negotiator protein that regulates dopaminergic cell death in substantia nigra and their protection in ventral tegmental area in Parkinson's Disease.

4. Elevated PHB levels in EAE brains signify the role of PHB in regulating ROS and implies PHB's role in oxidative stress.

5. obesity-associated hyperinsulinemia promotes tumor development by facilitating dormant mutant to manifest and reveals a sex-dimorphic role of PHB in adipose-immune interaction or immunometabolism.

6. results demonstrate that the H19-Igf2 axis is negatively regulated by CTCF-PHB1 cooperation and that H19 is involved in modulating the growth-suppressive effect of PHB1 in the liver.

7. Study shows that PHB is highly expressed in white adipose tissue and liver which expression is regulated by estrogen.

8. This study identifies a novel signaling pathway composed of miR-361 and PHB1 that regulates mitochondrial fission program and apoptosis.

9. Both c-Myc and PHB1 directly interact with Nrf2 but c-Myc lowers Nrf2 binding to antioxidant response elemens while PHB1 enhances it.

10. A role for PHB in GnRH-induced cell death in mature gonadotropes, which is crucial for the normal development and function of the reproductive axis.

11. Data indicate that phosphorylation of Tyr114 and Tyr259 of prohibitin (PHB) is critical for the association of PHB with FcRI and Syk.

12. maintaining expression of intestinal epithelial cell prohibitin reduces the severity of inflammation and increases colonic levels of the antioxidants HO-1 and NQO-1 via a mechanism independent of Nfe2

13. Phb1/2 and the CD86 cytoplasmic domain cooperate to mediate CD86 signaling in a B cell through differential phosphorylation of distal signaling intermediates required to increase IgG1.

14. Findings suggest that PHB protects against colitis-associated cancer by modulating p53- and STAT3-mediated apoptosis.

15. Phb1 deficiency is a potential driver of chronic liver diseases by inducing hepatocyte damage and inflammation.

16. Identified PHB as an important protein in adipocyte differentiation. Furthermore, the overexpression of PHB in 3T3-L1 fibroblasts was sufficient to induce adipogenesis.

17. PHB1 and PHB2 are critical mediators in promoting 3T3-L1 adipocyte differentiation and may be the potential targets for obesity therapies

18. These results suggest that under inflammatory conditions there is decreased expression of vitamin D receptor resulting in decreased expression of prohibitin. Vitamin D deficiency decreased the expression of vitamin D receptor and prohibitin.

19. findings indicate that the defect in p53 function and the increased proteolysis of IGFBP-4, we had observed, represent two components of the same pathway, which contributes to the oncogenic function of Skp2B

20. This study demonstrates that prohibitin (PHB) is an estrogen-regulated gene and that PHB is essential for mouse uterine development and adult function and selectively required for estrogen-regulated gene expression.

Xenopus laevis Prohibitin (PHB) Interaktionspartner

1. Data show that protein-tyrosine phosphatase PRP4A3 (prl3) and van gogh like1 (vangl1) are Necessary Components in prohibitin1 (phb1) dependent neural crest specification.

2. Xphb1 represses E2F1 activity.

Cow (Bovine) Prohibitin (PHB) Interaktionspartner

1. Prohibitin is involved in oxidative stress signaling in the retina and retinal pigment epithelium.