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Using quantitative biochemical, biophysical, and solution structural methods study shows that ligand and DNA cooperatively recruit the intrinsically disordered steroid receptor coactivator-2 (SRC-2/TIF2/GRIP1/NCoA-2) receptor interaction domain to peroxisome proliferator-activated receptor gamma (zeige PPARG Proteine)-retinoid X receptor alpha (zeige RXRA Proteine) (PPARgamma (zeige PPARG Proteine)-RXRalpha (zeige RXRA Proteine)) heterodimer and reveal the binding determinants of the complex.
T3 promotes differentiation towards chondrocytes-like cells in our in vitro model, that this differentiation is mediated by steroid receptor (zeige ESR2 Proteine) co-activator 2 (SRC2) and does not induce hypertrophy
Pancreatic involvement occurs in mesenchymal chondrosarcoma harboring the HEY1 (zeige HEY1 Proteine)-NCOA2 gene fusion.
Data suggest that steroid receptor (zeige ESR2 Proteine) coactivators (NCOA1 (zeige NCOA1 Proteine), NCOA2, NCOA3 (zeige NCOA3 Proteine)) are over-expressed in a number of hormone-dependent cancers where they promote tumor growth, invasion, metastasis, and chemo-resistance; with their multiple roles in cancer, steroid receptor (zeige ESR2 Proteine) coactivators are promising targets for development of antineoplastic agents that can interfere with their function. [REVIEW]
SRC-2 may exhibit oncogenic or tumor suppressor activity depending on the target genes and nuclear receptors that are expressed in distinct tissues
NCOA2ETV4 protein would contain the helixloophelix, PAS_9 and PAS_11, CITED domains, the SRC1 (zeige SRC Proteine) domain of NCOA2 and the ETS (zeige ETS1 Proteine) DNAbinding domain of ETV4 (zeige ETV4 Proteine).
Altered expression of TIF2 may play a role in adenomyosis development and treatment outcome with levonorgestrel-releasing intrauterine system.
evaluating if NCOA2 relative copy-number gain presents prognostic value for prostate cancer
Report NcoA2-regulation of the AhR (zeige AHR Proteine)-ARNT (zeige ARNT Proteine)-HIF-1a (zeige HIF1A Proteine) interaction.
Data suggest that LRH1/NR5A2 (zeige NR5A2 Proteine) (liver receptor homologue-1) exhibits phospholipid-mediated allosteric control of protein-protein binding interface in interactions with TIF2 and SHP (zeige LAMC1 Proteine) (co-repressor; small heterodimer partner (zeige NR0B2 Proteine) protein).
studies demonstrate that SRC-2 provides an essential link between the behavioral activities influenced by light cues and the metabolic homeostasis maintained by the liver
the expression of MOZ-TIF2 fusion protein represses the transcription of p16INK4a and p19ARF and blocks senescence.
findings position SRC-2 as a major regulator of polygenic inputs to metabolic gene regulation and perhaps identify a previously unappreciated model that helps to explain the clinical spectrum of glucose dysregulation
fetal lungs produce signals to initiate labor when mature, and SRC-1 (zeige NCOA1 Proteine)/-2-dependent production of SP-A (zeige SFTPA1 Proteine) and PAF (zeige PAF Proteine) is crucial for this process
In a murine model, overexpression of NCoA2 in the prostate epithelium resulted in neoplasia.
the PAX3 (zeige PAX3 Proteine)-NCOA2 fusion gene has a dual role in the tumorigenesis of rhabdomyosarcoma
Transcription factor 23 (Tcf23 (zeige TCF23 Proteine)), a basic-helix-loop-helix transcription factor (zeige HEY1 Proteine), is a new progesterone-induced target gene that requires SRC-2 for full induction.
SRC-2 is a transcriptional coactivator for BMAL1 (zeige ARNTL Proteine):CLOCK. Ablation of SRC-2 disrupts the central clock.
SRC-2 is critical to transcriptional control modulated by MEF2 (zeige MEF2C Proteine), GATA-4 (zeige GATA4 Proteine), and Tbx5 (zeige TBX5 Proteine), thereby enhancing gene expression associated with cardiac growth.
SRC2 regulates anxiety response with SRC2(-/-) females showing decreased anxiety in novel environments.
The tif2 is involved in embryogenesis and in primitive hematopoiesis. tif2-knockdown zebrafish embryos are smaller than controls.
SNP 1718 in the NCOA2 gene was significant for early pregnancy probability (P=0.02) and age at first calving (P=0.03), and SNP 2038 in the same gene was significant for days to calving (P=0.03).
The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997
class E basic helix-loop-helix protein 75
, glucocorticoid receptor-interacting protein-1
, transcriptional intermediary factor 2
, glucocorticoid receptor interacting protein 1
, glucocorticoid receptor-interacting protein 1
, steroid receptor coactivator 2
, nuclear receptor coactivator 2
, transcriptional intermediary factor-2
, Transcriptional intermediary factor 2
, nuclear receptor coactivator 2-like