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Mouse (Murine) Polyclonal DAB2 Primary Antibody für WB - ABIN1881248
Collaco, Jakab, Hegan, Mooseker, Ameen: Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine. in The Journal of biological chemistry 2010
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DAB2 might be involved in excessive aldosterone biosynthesis and correlate with specific clinical characteristics of aldosterone-producing adenoma patients.
the results indicated that substrate stiffness could regulate EMT (zeige ITK Antikörper) of cervical cancer cell lines HeLa and SiHa at least partially through miR (zeige MLXIP Antikörper)-106b and its downstream target DAB2.
DAB2 can suppress the ERK (zeige EPHB2 Antikörper) signaling, but correlate to have TGF-beta (zeige TGFB1 Antikörper)-induced epithelial-to-mesenchymal transition (EMT (zeige ITK Antikörper)) in esophageal squamous cell carcinomas (ESCCs).
The various novel mechanisms are described by which Dab2 mediates an array of signaling events with vast physiological consequences.
In conclusion, DAB2 and Intelectin-1 (zeige ITLN1 Antikörper) are newly identified positive markers of mesothelioma and have potential to be included in future immunohistochemical marker panels for differentiation of epithelioid mesothelioma from pulmonary adenocarcinoma
cathepsin B (CTSB (zeige CTSB Antikörper)) inhibition or expression of a CTSB (zeige CTSB Antikörper)-resistant Dab2 mutant maintains Dab2 expression and shifts long-term TGF-beta (zeige TGFB1 Antikörper)-treated cells from autophagy to apoptosis
abundances of megalin (zeige LRP2 Antikörper) and Dab2 (p = 0.046) were reduced in infected placentas from women with LBW deliveries
Data show that miR106b was frequently up-regulated in human cervical carcinoma tumors and cell lines and inversely correlated with DAB2 expression. Its regulation in under TGF-beta1 (zeige TGFB1 Antikörper) which contributes to cell migration by targeting DAB2 in cervical carcinoma.
these findings reveal that DAB2 is critical for controlling inflammatory signaling during phenotypic polarization of macrophages
inhibition of WNT (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling by DAB2 is essential for establishing the correct number of cardiomyocytes in the developing heart.
Dab2 functions as a negative immune regulator of TLR4 (zeige TLR4 Antikörper) endocytosis and signaling; it has a role in the regulatory circuit in controlling the inflammatory response of macrophages to endotoxin
The results suggest that Dab2 is required for the excessive calorie-induced differentiation of an adipocyte progenitor cell population that is present in juvenile but depleted in mature animals. The finding provides evidence for a limited pre-adipocyte population in juvenile mammals and the requirement of Dab2 in the regulation of Ras/MAPK (zeige MAPK1 Antikörper) signal in the commitment of the precursor cells to adipose tissues.
The combination of Arh (zeige LDLRAP1 Antikörper) and Dab2 is responsible for the majority of adaptor function in LDLR (zeige LDLR Antikörper) endocytosis and LDLR (zeige LDLR Antikörper)-mediated cholesterol homeostasis.
Results identified a novel activation marker, DAB2, which expression is significantly different between microglia activation stages M2a and either M1 or M2b.
Dab2 expression is induced by hormones
Results suggest that endogenous Dab2 exacerbates central nervous system inflammation, potentially acting to up-regulate reactive oxygen species expression in macrophages and microglia, and that it is of potential pathogenic relevance in multiple sclerosis
Disabled-2 is required for efficient hemostasis and platelet activation by thrombin (zeige F2 Antikörper) in mice.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (zeige IL8 Antikörper) and PTGS2 (zeige PTGS2 Antikörper), and decreased the expression of SOD2 (zeige SOD2 Antikörper), GPX3 (zeige GPX3 Antikörper), DAB2, and NR3C1 (zeige NR3C1 Antikörper). TNF (zeige TNF Antikörper) and IL6 (zeige IL6 Antikörper) levels were also decreased while those of NAMPT (zeige NAMPT Antikörper) were unaffected.
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
, disabled homolog 2
, disabled homolog 2, mitogen-responsive phosphoprotein
, disabled homolog 2-like
, differentially-expressed protein 2
, mitogen-responsive phosphoprotein
, DOC-2 p82 isoform
, disabled homolog 2 mitogen-responsive phosphoprotein