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DAB2 Produkte

(Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))

Kategorien

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

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Ausgewählte DAB2 Kategorien

DAB2 Antikörper

High quality antibodies with extensive validation data.

DAB2 ELISA Kits

Reliable ELISA kits for a wide range of species.

DAB2 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene DAB2 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation IF, WB
Validierungen
  • (4)
Kat. Nr. ABIN514859
Menge 50 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, IHC, WB
Validierungen
  • (3)
Kat. Nr. ABIN7129145
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation IHC (p), WB
Validierungen
  • (3)
Kat. Nr. ABIN2854661
Menge 100 μL
Datenblatt Datenblatt

Empfohlene DAB2 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6966388
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN4882557
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method
Validierungen
Kat. Nr. ABIN1129853
Menge 96 tests
Datenblatt Datenblatt

Empfohlene DAB2 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3092048
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Mouse
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3134739
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1351061
Menge 10 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren DAB2 Produkten

Jiang, Woosley, Sivalingam, Natarajan, Howe: "Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-β-induced autophagy." in: Nature cell biology, Vol. 18, Issue 8, pp. 851-63, (2016) (PubMed).

Herzog, Josseaux, Dedeurwaerder, Calonne, Volkmar, Fuks: "The histone demethylase Kdm3a is essential to progression through differentiation." in: Nucleic acids research, Vol. 40, Issue 15, pp. 7219-32, (2012) (PubMed).

Cihil, Ellinger, Fellows, Stolz, Madden, Swiatecka-Urban: "Disabled-2 protein facilitates assembly polypeptide-2-independent recruitment of cystic fibrosis transmembrane conductance regulator to endocytic vesicles in polarized human airway epithelial cells." in: The Journal of biological chemistry, Vol. 287, Issue 18, pp. 15087-99, (2012) (PubMed).

Collaco, Jakab, Hegan, Mooseker, Ameen: "Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine." in: The Journal of biological chemistry, Vol. 285, Issue 22, pp. 17177-87, (2010) (PubMed).

Chaudhury, Hussey, Ray, Jin, Fox, Howe: "TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI." in: Nature cell biology, Vol. 12, Issue 3, pp. 286-93, (2010) (PubMed).

Hasumi, Baba, Ajima, Hasumi, Valera, Klein, Haines, Merino, Hong, Yamaguchi, Schmidt, Linehan: "Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 44, pp. 18722-7, (2009) (PubMed).

Jain, Nguyen, Friedline, Malhotra, Brehm, Koyanagi, Bix, Cooper, Chambers, Kang: "Cutting edge: Dab2 is a FOXP3 target gene required for regulatory T cell function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 7, pp. 4192-6, (2009) (PubMed).

Jiang, Luo, Howe: "Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions." in: Oncogene, Vol. 28, Issue 33, pp. 2999-3007, (2009) (PubMed).

Mishra, Keyel, Hawryluk, Agostinelli, Watkins, Traub: "Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor." in: The EMBO journal, Vol. 21, Issue 18, pp. 4915-26, (2002) (PubMed).

Hocevar, Smine, Xu, Howe: "The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway." in: The EMBO journal, Vol. 20, Issue 11, pp. 2789-801, (2001) (PubMed).

Synonyme und alternative Namen zu DAB2

DAB2, clathrin adaptor protein (DAB2), disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (dab2), Dab, mitogen-responsive phosphoprotein, homolog 2 (dab2), DAB2, clathrin adaptor protein (Dab2), disabled 2, mitogen-responsive phosphoprotein (Dab2), 5730435J12Rik, AA960054, AI957090, D15Wsu122e, D630005B22Rik, DOC-2, Doc-2, DOC2, Doc2, p96

Bezeichner auf Proteinebene für DAB2

  • disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
  • disabled homolog 2
  • disabled homolog 2, mitogen-responsive phosphoprotein
  • disabled homolog 2-like
  • differentially-expressed protein 2
  • mitogen-responsive phosphoprotein
  • C9
  • DOC-2 p82 isoform
  • disabled homolog 2 mitogen-responsive phosphoprotein
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