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anti-Human ARID1A Antikörper:
anti-Mouse (Murine) ARID1A Antikörper:
anti-Rat (Rattus) ARID1A Antikörper:
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Human Polyclonal ARID1A Primary Antibody für ICC, IF - ABIN4281563
Bolander, Agnarsdóttir, Strömberg, Ponten, Hesselius, Uhlen, Bergqvist: The protein expression of TRP-1 and galectin-1 in cutaneous malignant melanomas. in Cancer genomics & proteomics 2009
Show all 21 Pubmed References
Human Polyclonal ARID1A Primary Antibody für WB - ABIN188644
Wurster, Precht, Pazin: NF-κB and BRG1 bind a distal regulatory element in the IL-3/GM-CSF locus. in Molecular immunology 2011
Loss of PTEN and ARID1A expression is highly specific for malignancy in effusion pathology
We propose a signaling cascade involving ARID1A, GADD45B (zeige GADD45B Antikörper) and DUSP1 (zeige DUSP1 Antikörper) as mediators of the romidepsin effects in GCC (zeige GUCY2C Antikörper) cells.
head and neck squamous cell carcinoma patients with tumors having high level of miR (zeige MLXIP Antikörper)-31 expression and high levels of Nanog (zeige NANOG Antikörper)/OCT4 (zeige POU5F1 Antikörper)/Sox2 (zeige SOX2 Antikörper)/EpCAM (zeige EPCAM Antikörper) expression, together with low level of ARID1A expression, were found to have the worst survival
loss of ARID1A leads to accumulation of ROS (zeige ROS1 Antikörper); elesclomol may be used to target ARID1A-mutant gynecologic cancer cells
genomic data and clinical features of four patients carrying a small 1p36.11 microduplication encompassing the complete ARID1A gene
Data show that 38 samples of 82 ovarian clear cell carcinoma (CCC) specimens presented no BAF250a expression, and 50 samples exhibited the loss of at least one subunit of the SWI (zeige SMARCA1 Antikörper)/SNF (zeige SNRPA Antikörper) complex.
Mutations of ARID1A, GPRC5A (zeige GPRC5A Antikörper) and MLL2 (zeige MLL2 Antikörper) grant bladder cancer non-stem cells the capability of self-renewal.
Partial loss (i.e. in one tissue section some cells stained positive for BAF250a while other cells, usually an adjacent group, were negative) of BAF250a protein was identified in 36% (9/25) of rectovaginal DIE samples, 40% (2/5) of endometriosis lesions involving the PSLN, 30% (6/20) of endometriomas, and also in 25% (5/20) of endometrium from controls.
In the very high-risk Bladder Cancer patients , several genes had a higher frequency of mutations than reported in the The Cancer Genome Atlas database, including ARID1A . Mutation associations with receipt of neoadjuvant chemotherapy, nodal involvement, metastatic disease development, and survival were analyzed.
Tumors accumulate ARID1A mutations.
Our results identified PIK3IP1 (zeige PIK3IP1 Antikörper) as a novel target of ARID1A and PGR (zeige PGR Antikörper) in the murine uterus.
Mice with liver-specific homozygous or heterozygous Arid1a loss were resistant to tumor initiation while ARID1A overexpression accelerated initiation.
Loss of HDAC (zeige HDAC3 Antikörper)-mediated repression and gain of NF-kappaB (zeige NFKB1 Antikörper) activation underlie cytokine induction in ARID1A- and PIK3CA (zeige PIK3CA Antikörper)-mutation-driven ovarian cancer.
ARID1A mutation inactivates the apoptosis-promoting function of p53 (zeige TP53 Antikörper) by upregulating HDAC6 (zeige HDAC6 Antikörper), indicating that pharmacological inhibition of HDAC6 (zeige HDAC6 Antikörper) is a therapeutic strategy for ARID1A-mutated cancers.
ARID1A normally targets SWI (zeige SMARCA1 Antikörper)/SNF (zeige SNRPA Antikörper) complexes to enhancers.
Consistent with the latter, Arid1a reexpression in tumor cells led to increased p21 (Cdkn1a (zeige CDKN1A Antikörper)) expression and dramatic accumulation of cells in G2 phase of the cell cycle. These results also indicate a potential opportunity for therapeutic intervention in ARID1A-deficient human breast cancer subtypes that retain one intact copy of the gene and also maintain wild-type TRP53 (zeige TP53 Antikörper) activity
The Arid1a loss reprograms chromatin to restrict promoter access by transcription factors such as C/ebpalpha (zeige CEBPA Antikörper), which enforces differentiation, and E2F4 (zeige E2F4 Antikörper), which suppresses cell-cycle re-entry.
This study provides an alternative mechanism by which Arid1a deficiency contributes to hepatocellular carcinoma tumorigenesis.
ARID1A positively regulates Klf15 (zeige KLF15 Antikörper) expression with PGR (zeige PGR Antikörper) to inhibit epithelial proliferation at peri (zeige POSTN Antikörper)-implantation. Our results suggest that Arid1a has a critical role in modulating epithelial proliferation which is a critical requisite for fertility
Our results indicate that the Arid1a tumour suppressor gene has a key role in regulating ovarian endometrioid carcinoma differentiation
This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene.
ARID domain-containing protein 1A
, AT-rich interactive domain-containing protein 1A
, BRG1-associated factor 250a
, OSA1 nuclear protein
, SWI-like protein
, SWI/SNF complex protein p270
, SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1
, brain protein 120
, chromatin remodeling factor p250
, osa homolog 1
, AT rich interactive domain 1A (Swi1 like)
, BRG1-associated factor 250
, SWI-SNF complex protein p270
, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1
, Swi1 like
, AT rich interactive domain 1A (SWI-like)
, AT-rich interactive domain-containing protein 1A-like