ARID1A Antikörper (AA 1930-1964)

Produktnummer ABIN6243038

Produktdetails anti-ARID1A Antikörper

Target: ARID1A (AT Rich Interactive Domain 1A (SWI-Like) (ARID1A))

Bindungsspezifität: AA 1930-1964

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARID1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ARID1A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1930-1964 amino acids from human ARID1A.

Klon: RB53541

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu ARID1A

Target: ARID1A (AT Rich Interactive Domain 1A (SWI-Like) (ARID1A))

Andere Bezeichnung: ARID1A (ARID1A Produkte)

Synonyme: B120 antikoerper, BAF250 antikoerper, BAF250a antikoerper, BM029 antikoerper, C1orf4 antikoerper, ELD antikoerper, MRD14 antikoerper, OSA1 antikoerper, P270 antikoerper, SMARCF1 antikoerper, hELD antikoerper, hOSA1 antikoerper, 1110030E03Rik antikoerper, Osa1 antikoerper, Smarcf1 antikoerper, ARID1A antikoerper, wu:fb79b07 antikoerper, wu:fb95g08 antikoerper, zgc:171438 antikoerper, AT-rich interaction domain 1A antikoerper, AT rich interactive domain 1A (SWI-like) antikoerper, AT rich interactive domain 1Aa (SWI-like) antikoerper, ARID1A antikoerper, Arid1a antikoerper, arid1a antikoerper, arid1aa antikoerper

Hintergrund: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Also involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Molekulargewicht: 242045

UniProt: O14497

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Tube Formation