Swinholide A
Kurzübersicht für Swinholide A (ABIN924961)
Applikation
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Verwendungszweck
- Swinholide A is a natural dimeric dilactone macrolide toxin that causes actin depolymerization in cells.
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Reinheit
- > 98 % (HPLC)
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Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
Anacardic AcidInh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid
EX-527Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)
ResveratrolAct 501-36-0 3,4',5-Trihydroxy-trans-stilbene
SAHA (Vorinostat)Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid
Phenylbutyrate NaInh 1716-12-7 4-Phenylbutyric acid, sodium salt
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Applikationshinweise
- Can be used in cell biology to distinguish between the effects induced by increasing intracellular concentrations of G-actin from those induced by a reduction in F-actin.
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Kommentare
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Formula: C78H132O20
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Oil
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Lagerung
- -20 °C
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Hintergrund
- Swinholide A is a 44-carbon dimeric dilactone ring macrolide isolated from the marine sponge Theonella swinhoei. In vitro, it sequesters actin dimers with a binding stochiometry of 1:1, and it rapidly severs F-actin with high cooperativity. Swinholice A is potently cytotoxic by disruption of the actin cytoskeleton. It does not block progression of cells through the cell cycle, but does prevent cytokinesis. Cytotoxcity: Cell Type IC50 (µg/ml) KB Oral, epidermoid cell carcinoma 0.04 HT-1080 Fibrosarcoma 0.017 PC-3 Lung, adenocarcinoma 6.0 PC-9 Lung, adenocarcinoma 0.13 PC-10 Lung, squamous cell carcinoma 0.11 PC-13 Lung, large cell carcinoma 0.10 Daudi Burkitt lymphoma 0.036.
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Molekulargewicht
- 1388.9 Da
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