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UNC-2170 HCl

Name: UNC-2170 HCl
Brand: antibodies-online
SKU: ABIN7233306
Price: 150.77 EUR
Availability: InStock

Inh 1648707-58-7 3-Bromo-N-(3-(tert-butylamino)propyl)benzamide, hydrochloride

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Produktnummer ABIN7233306

Datenblatt (PDF)

Quick Overview for UNC-2170 HCl (ABIN7233306)

Applikation

Inhibition (Inh)

Chemical Name

3-Bromo-N-(3-(tert-butylamino)propyl)benzamide, hydrochloride

Verwendungszweck

Methyl-lysine binding protein inhibitor

Produktmerkmale

UNC-2170, identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170 functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.

Reinheit

>98 %

Formel

C14H21BrN2O • HCl

Löslichkeit

Soluble in DMSO (up to 40 mg/ml) or in Water (up to 50 mg/ml)
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Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Powder

Vorsichtsmaßnahmen

GHS – Classification
Not a hazardous substance

Lagerung

-20 °C
Hintergrund

Epigenetics,DNA,Chromatin,DNA repair

Molekulargewicht

349.7

CAS-Nummer

1648707-58-7