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Tranylcypromine hemisulfate (±)

Name: Tranylcypromine hemisulfate (±)
Brand: antibodies-online
SKU: ABIN7233300
Price: 96.92 EUR
Availability: InStock

Inh Cell-permeable 13492-01-8 Trans (±)-2-phenylcyclopropanamine, hemisulfate salt

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Produktnummer ABIN7233300

Datenblatt (PDF)

Quick Overview for Tranylcypromine hemisulfate (±) (ABIN7233300)

Applikation

Inhibition (Inh)

Chemical Name

Trans (±)-2-phenylcyclopropanamine, hemisulfate salt

Permeabilität

Cell-permeable

Verwendungszweck

Demethylase inhibitor

Produktmerkmale

Irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) IC50 < 2 μM. Tranylcypromine treatment of P19 embryonal carcinoma cells resulted in global increase of H3K4 methylation along with transcriptional derepression of two BHC110 target genes, Egr1 and Oct4. When combined with CHIR99021, induces the generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Reduces proliferation, cell cycle progression and invasiveness of endometriotic stromal cells. Upregulates CD86 expression in THP1 cells. Monoamine oxidase inhibitor. Cell permeable and active in vivo.

Reinheit

>98 %

Formel

C9H11N 1/2(H2SO4)

Löslichkeit

Soluble in Water (up to 25 mg/ml).
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Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Powder

Lagerung

-20 °C
Hintergrund

2-PCPA, SKF-385,Epigenetics,Protein demethylase,Monoamine oxidase,Stem cells,Neuroscience,Mood disorders,Chromatin,Posttranslational Modification

Molekulargewicht

182.23

CAS-Nummer

13492-01-8