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SRT1720 HCl

Name: SRT1720 HCl
Brand: antibodies-online
SKU: ABIN7233295
Price: 123.85 EUR
Availability: InStock

Act 1001645-58-4 N-[2-[3-(Piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide, hydrochloride

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Produktnummer ABIN7233295

Datenblatt (PDF)

Kurzübersicht für SRT1720 HCl (ABIN7233295)

Applikation

Activation (Act)

Chemical Name

N-[2-[3-(Piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide, hydrochloride

Verwendungszweck

SIRT1 activator

Produktmerkmale

Sirtuin1 (SIRT1) activator, EC1.5 = 0.16 μM, that reduces glucose levels and hyperinsulinemia in mouse and rat models of obesity. SRT1720 represses expression of circadian clock genes in vitro and in vivo. It inhibits vascular inflammation caused by angiotensin II-induced atherosclerosis and reverses abnormal mitochondrial function in primary neurons exposed to 20-HETE. Ameliorates hypoxic injury in pancreatic β-cells, and enhances ferroptosis in head and neck cancer cells.

Reinheit

>98 %

Formel

C25H23N7OS•HCl

Löslichkeit

Soluble in DMSO (up to at least 25 mg/ml)
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

5-Azacytidine
Inh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Nicotinamide
Inh 98-92-0 Pyridine-3-carboxylic acid amide

Anacardic Acid
Inh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid

EX-527
Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)

Resveratrol
Act 501-36-0 3,4',5-Trihydroxy-trans-stilbene

SAHA (Vorinostat)
Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid

Phenylbutyrate Na
Inh 1716-12-7 4-Phenylbutyric acid, sodium salt

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Powder

Lagerung

-20 °C
Hintergrund

SIRT 1933,Redox,Epigenetics,Apoptosis inhibitor,Mitochondrial function,Protein deacetylase,Oxidative stress,Cell death,Circadian rhythm,Diabetes,Kidney disease,Atherosclerosis,Inflammation,Posttranslational modification,Obesity,Chromatin

Molekulargewicht

506.0

CAS-Nummer

1001645-58-4