SirtAct (CAY-10591)
Kurzübersicht für SirtAct (CAY-10591) (ABIN7233290)
Applikation
Chemical Name
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Verwendungszweck
- SIRT1 activator
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Produktmerkmale
- Sirt1 activator (233 % at 10 μM)1 Suppresses TNFα release from THP-1 cells and stimulates adipogenesis in 3T3L1 cells. SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in mice. Inhibits NFκB activation and reduces inflammatory cytokine production in lamina propria mononuclear cells from IBD patients. Prevents and cures experimental colitis in a mouse model.
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Reinheit
- >98 %
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Formel
- C20H25N5O2
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Löslichkeit
- Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml).
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Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
Anacardic AcidInh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid
EX-527Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)
ResveratrolAct 501-36-0 3,4',5-Trihydroxy-trans-stilbene
SAHA (Vorinostat)Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid
Phenylbutyrate NaInh 1716-12-7 4-Phenylbutyric acid, sodium salt
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Powder
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Lagerung
- -20 °C
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Hintergrund
- CAY10591,Posttranslational modification,Epigenetics,Chromatin,Protein deacetylase,Diabetes,Inflammation,Cytokine,NFkappaB
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Molekulargewicht
- 367.46
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CAS-Nummer
- 839699-72-8
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