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Santacruzamate A

Name: Santacruzamate A
Brand: antibodies-online
SKU: ABIN7233286
Price: 103.38 EUR
Availability: InStock

Inh 1477949-42-0 N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester

1 image

Produktnummer ABIN7233286

Kurzübersicht für Santacruzamate A (ABIN7233286)

Applikation

Inhibition (Inh)

Chemical Name

N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester

Verwendungszweck

Ultrapotent HDAC2 inhibitor

Produktmerkmale

A highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium cf. Symploca (IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively). Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors. Potential therapeutic agent for breast cancer. Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance. Ameliorates Alzheimer's disease-like pathology in mouse models.

Reinheit

>98 %

Formel

C15H22N2O3

Löslichkeit

Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
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Radicicol
Inh 12772-57-5

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Resveratrol
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SAHA (Vorinostat)
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Phenylbutyrate Na
Inh 1716-12-7 4-Phenylbutyric acid, sodium salt

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Powder

Vorsichtsmaßnahmen

GHS – Classification
Not a hazardous substance

Lagerung

-20 °C
Hintergrund

Epigenetics,Posttranslational modification,Protein deacetylase,Neuroscience,Cell death,Cellular stress,Cancer,Neurodegeneration,Apoptosis inducer,Chromatin

Molekulargewicht

278.35

CAS-Nummer

1477949-42-0