Kurzübersicht für Mithramycin A (ABIN7233267)
Applikation
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Verwendungszweck
- Transcription inhibitor, Inhibits DNA methyltransferase
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Produktmerkmale
- Inhibits DNA methyl transferase. A selective Sp1 inhibitor, it binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, inhibitings their expression. Mithramycin A (at 10-200 nM) sensitizes tumor cells to TRAIL-induced apoptosis.
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Reinheit
- >98 %
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Formel
- C52H76O24
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Löslichkeit
- Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml).
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Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
Anacardic AcidInh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid
EX-527Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)
ResveratrolAct 501-36-0 3,4',5-Trihydroxy-trans-stilbene
SAHA (Vorinostat)Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid
Phenylbutyrate NaInh 1716-12-7 4-Phenylbutyric acid, sodium salt
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Powder
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Vorsichtsmaßnahmen
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GHS – Classification
Acute toxicity, Oral (Category 4), H302 -
Lagerung
- -20 °C
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Hintergrund
- A2371, Antibiotic LA 7017, Aureolic Acid, NSC 24559, PA 144, Plicamycin,Epigenetics,Chromatin,DNA methyltransferase,RNA,Antibiotic,Cell death,Infectious disease,Apoptosis inducer,Transcription
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Molekulargewicht
- 1085.15
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CAS-Nummer
- 18378-89-7
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