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GSK-J4

Inh Cell-permeable 1373423-53-0 N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
Produktnummer ABIN7233259

Kurzübersicht für GSK-J4 (ABIN7233259)

Applikation

Inhibition (Inh)

Chemical Name

N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester

Permeabilität

Cell-permeable
  • Verwendungszweck

    JMJ H3K27 Demethylase inhibitor (cell permeable)

    Produktmerkmale

    Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J1. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.

    Reinheit

    >98 %

    Formel

    C24H27N5O2

    Löslichkeit

    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml).
  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Wax

    Lagerung

    -20 °C
  • Hintergrund

    Epigenetics,Posttranslational modification,Protein demethylase,Immunology,Inflammation,Cytokine,Chromatin

    Molekulargewicht

    417.48

    CAS-Nummer

    1373423-53-0
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