GSK-J4
Kurzübersicht für GSK-J4 (ABIN7233259)
Applikation
Chemical Name
Permeabilität
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Verwendungszweck
- JMJ H3K27 Demethylase inhibitor (cell permeable)
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Produktmerkmale
- Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J1. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.
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Reinheit
- >98 %
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Formel
- C24H27N5O2
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Löslichkeit
- Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml).
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Wax
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Lagerung
- -20 °C
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Hintergrund
- Epigenetics,Posttranslational modification,Protein demethylase,Immunology,Inflammation,Cytokine,Chromatin
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Molekulargewicht
- 417.48
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CAS-Nummer
- 1373423-53-0
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