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CPI-455

Inh 1628208-23-0 7-Oxo-5-phenyl-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile

1 image

Produktnummer ABIN7233243

Datenblatt (PDF)

Applikation

Inhibition (Inh)

Verwendungszweck

Lysine demethylase KDM5 inhibitor

Produktmerkmale

CPI-455 (1628208-23-0) is a potent (IC50 = 10 nM) and selective inhibitor of the lysine demethylase KDM5 (equal inhibition of KDM5A, 5B, 5C). CPI-455 reduced the number of drug-tolerant persister cancer cells (DTPs) in a dose-dependent, KDM5-dependent manner in multiple cell lines treated with standard chemotherapy or targeted agents. CPI-455 synergized with 5-aza-2'-deoxycytidine (DAC) to reduce the viability of luminal breast cancer cells in vitro. KDM5 demethylases have recently been shown to repress the immune response to tumors via suppression of STING.

Reinheit

>98 %

Chemical Name

7-Oxo-5-phenyl-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile

Formel

C16H14N4O

Löslichkeit

Soluble in DMSO (up to at least 25 mg/ml)
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Nicotinamide
Inh 98-92-0 Pyridine-3-carboxylic acid amide

5-Azacytidine
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Panobinostat
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HPA (Hexyl-4-pentynoic acid)
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EX-527
Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)

Daminozide
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Mithramycin A
Inh 18378-89-7

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Powder

Lagerung

-20 °C
Hintergrund

Epigenetics,Chromatin,Protein demethylase,STING,Immunology,Cancer,Posttranslational modification,Cytokine

Molekulargewicht

278.32

CAS-Nummer

1628208-23-0