Kurzübersicht für CI-994 (ABIN7233242)
Applikation
Chemical Name
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Verwendungszweck
- HDAC inhibitor
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Produktmerkmale
- Orally active histone deacetylase (HDAC) inhibitor, IC50 = 0.9, 0.9, 1.2 and >20 μM for HDAC1, HDAC2, HDAC3 and HDAC8 respectively. Mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo. Increases neuroplasticity during memory extinction. Protects beta cells from cytokine-induced apoptosis.
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Reinheit
- >98 %
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Formel
- C15H15N3O2
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Löslichkeit
- Soluble in DMSO (up to 25 mg/ml)
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Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
Anacardic AcidInh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid
EX-527Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)
ResveratrolAct 501-36-0 3,4',5-Trihydroxy-trans-stilbene
SAHA (Vorinostat)Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid
Phenylbutyrate NaInh 1716-12-7 4-Phenylbutyric acid, sodium salt
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Powder
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Lagerung
- -20 °C
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Hintergrund
- PD-123654, N-acetyl-dinaline, GOE-5549,Cytokine,Epigenetics,Apoptosis inducer,Proliferation,Posttranslational modification,Protein deacetylase,Neuroscience,Cell death,Inflammation,Diabetes,Cell cycle,Chromatin
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Molekulargewicht
- 269.30
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CAS-Nummer
- 112522-64-2
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