CHS-828 (GMX-1778)
Kurzübersicht für CHS-828 (GMX-1778) (ABIN7233241)
Applikation
Chemical Name
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Verwendungszweck
- NAMPT inhibitor
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Produktmerkmale
- A potent and selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the biosynthesis of NAD, which may be used to deplete cells of NAD. Displays potent cytotoxic effects in tumor cells. Displays antitumor activity in vivo. Increases ROS levels in cancer cells but not in normal cells.
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Reinheit
- >98 %
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Formel
- C19H22ClN5O
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Löslichkeit
- Soluble in DMSO up to 25 mg/ml)
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Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
Anacardic AcidInh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid
EX-527Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)
SAHA (Vorinostat)Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid
Phenylbutyrate NaInh 1716-12-7 4-Phenylbutyric acid, sodium salt
AS-8351Inh 796-42-9 2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Powder
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Lagerung
- -20 °C
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Hintergrund
- GMX-1778,Chromatin,Epigenetics,Cytokine,Stem cells,Cell death,Cancer,Cytotoxicity,NAD, NADP pathways
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Molekulargewicht
- 371.86
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CAS-Nummer
- 200484-11-3
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