Kurzübersicht für AK-7 (ABIN7233230)
Applikation
Chemical Name
-
-
Verwendungszweck
- SIRT2 inhibitor
-
Produktmerkmale
- A selective Sirt2 inhibitor (IC50=15.5 956M) which does not inhibit Sirt1 or Sirt31. It down-regulates cholesterol biosynthesis genes in primary striatal neurons. Displays neuroprotective effects in Huntington's disease mouse models including improved motor function, extended survival and reduced brain atrophy all of which were associated with reduced aggregated mutant huntingtin. Ameliorates β-amyloid pathology and cognitive imparement in an Alzheimer's disease mouse model.
-
Reinheit
- >98 %
-
Formel
- C19H21BrN2O3S
-
Löslichkeit
- Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
-
-
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
Anacardic AcidInh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid
EX-527Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)
SAHA (Vorinostat)Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid
Phenylbutyrate NaInh 1716-12-7 4-Phenylbutyric acid, sodium salt
AS-8351Inh 796-42-9 2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone
-
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Powder
-
Lagerung
- RT
-
-
-
Hintergrund
- Epigenetics,Posttranslational modification,Protein deacetylase,Neuroscience,Ageing,Neurodegeneration,Cholesterol metabolism,Chromatin
-
Molekulargewicht
- 437.36
-
CAS-Nummer
- 420831-40-9
-
-
