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Ibudilast

InhA, Func 50847-11-5

Produktnummer ABIN4876463

Datenblatt (PDF)

Applikation

Inhibition Assay (InhA), Functional Studies (Func)

Verwendungszweck

Ibudilast is an anti-inflammatory and neuroprotective oral agent which shows an excellent safety profile at 60 mg/day and provides significantly prolonged time-to-first relapse and attenuated brain volume shrinkage in patients with relapsing-remitting (RR) and/or secondary progressive (SP) multiple sclerosis (MS). Ibudilast is currently in development in the U.S. (codes: AV-411 or MN-166), but is approved for use as an antiinflammatory in Japan.

Produktmerkmale

Tradename: KC-404, MN-166
Target: PDE inhibitor
Receptor: PDE

Aufreinigung

All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.

Reinheit

99 %

Formel

C14H18N2O

Löslichkeit

DMSO:28 mg/ml,100 mM in ethanol
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Nicotinamide
Inh 98-92-0 Pyridine-3-carboxylic acid amide

5-Azacytidine
Inh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Panobinostat
Inh 404950-80-7 (E)-N-Hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide

HPA (Hexyl-4-pentynoic acid)
Inh Cell-permeable 96017-59-3 2-(2-Propynyl)octanoic acid (racemic)

EX-527
Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)

Daminozide
Inh 1596-84-5 1-(2,2-Dimethylhydrazide)butanedioic acid

Mithramycin A
Inh 18378-89-7

Applikationshinweise

Optimal working dilution should be determined by the investigator.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Solid

Lagerung

-20 °C

Informationen zur Lagerung

For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.

Haltbarkeit

24 months
Hintergrund

Metabolism

Molekulargewicht

230.51 g/mol

CAS-Nummer

50847-11-5